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BEGIN:VEVENT
DTSTART;TZID=UTC:20190610T120000
DTEND;TZID=UTC:20190610T130000
DTSTAMP:20260513T200621
CREATED:20190530T230819Z
LAST-MODIFIED:20190604T034800Z
UID:21528-1560168000-1560171600@leadersinlight.com
SUMMARY:Anita Mahadevan-Jansen\, PhD
DESCRIPTION:Professor of Biomedical Engineering at Vanderbilt University  \nProblem-based research shortens the pathway to to clinical translation of light-based technologies\nAbstract\nMedicine is a problem rich environment where there is a critical need for new solutions that ease the life of the patient\, the physician and the caregiving staff. For at least some of these problems\, biophotonics could well be the answer! Optical techniques can be used to provide real-time assessment for screening\, diagnosis\, monitoring and guidance of therapy. In this presentation – I will discuss 2-3 different medical challenges and the optical solution that was developed and implemented in a clinical setting. These examples include the application of near infrared fluorescence imaging for the anatomical detection of the parathyroid gland during endocrine surgery and in vivo biochemical characterization of the pregnant human cervix towards understanding preterm birth.  \nBiography\nDr. Mahadevan-Jansen translates optical techniques for clinical detection of tissue physiology and pathology. Her primary research at the Vanderbilt Biophotonics Center\, is to investigate the applications of optical spectroscopies and imaging for disease diagnosis and guidance of therapy. She received her bachelor’s and master’s degrees in Physics from the University of Bombay (Mumbai)\, India\, and a master’s and PhD degrees in Biomedical Engineering from the University of Texas at Austin. She joined the Vanderbilt engineering faculty in 1996. She is currently the Orrin H. Ingram Professor of Biomedical Engineering at Vanderbilt University and holds a secondary appointment in the Departments of Neurological Surgery and Otolaryngology. She is the founding Director of the Vanderbilt Biophotonics Center\, the Director of the Vanderbilt branch of the Center for Integration of Research in Teaching and Learning (CIRTL)\, an NSF funded 46-institution center as well as Director of Undergraduate Studies for the Department of Biomedical Engineering at Vanderbilt University.\nShe is currently on the Board of Directors of the International Society for Optical Engineering (SPIE) and is a fellow of SPIE\, Optical Society of America (OSA) as well as the American Institute of Medical and Biological Engineering (AIMBE). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/anita-mahadevan-jansen-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/anita.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190606T123000
DTEND;TZID=UTC:20190606T133000
DTSTAMP:20260513T200621
CREATED:20190521T230028Z
LAST-MODIFIED:20190524T004017Z
UID:21481-1559824200-1559827800@leadersinlight.com
SUMMARY:Joseph A. Izatt\, PhD
DESCRIPTION:Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\nProfessor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University \nNew Optical Technologies for Real-Time Biomedical Imaging and Image-Guided Surgery\nAbstract\nCutting edge optical biomedical imaging technologies adaptively control optical wavefronts and exploit spatial and temporal coherence to obtain wavelength-scale measurements of structure and function inside living biological tissues\, while leveraging optical communications bandwidths to enable real-time 3D imaging. We have developed implementations of these technologies for multiple applications including super-resolved non-invasive retinal imaging\, flexible hand-held interactive clinical diagnostic imaging\, and real-time intrasurgical visualization and operative guidance. These advances allow for continuous volumetric microstructural imaging in living patients\, and extend the benefits of the latest imaging technologies to previously inaccessible patient populations. Using these tools\, we have demonstrated live imaging of individual retinal receptor cells both with and without adaptive optics\, including the first demonstrations of retinal cone cell imaging in infants and children. We have pioneered the integration of optical coherence tomography into ophthalmic microsurgery\, including surgical microscope-integrated image acquisition\, real-time augmented reality visualization\, and image-guided tele-operative and cooperative robotic manipulation of surgical tools with micrometer-scale precision. Several of these technologies have accomplished the transition from basic research\, to clinical trials\, to wide-scale adoption and commercial success\, and thus serve as useful examples of the accumulating impact and continuing importance of innovation in biomedical optics and biophotonics.  \nBiography\nJoseph A. Izatt is the Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\, Professor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University. Prof. Izatt’s research interests include biomedical optics and spectroscopy\, coherence-based and wavefront-optimized tomographic optical imaging\, and novel instrumentation for intrasurgical visualization and manipulation. He has authored over 200 peer-reviewed publications\, more than 350 contributed and 130 invited lectures and presentations\, and more than 70 issued patents\, which altogether have accumulated over 38\,000 citations. Izatt was the founding Editor-In-Chief of Biomedical Optics Express\, OSA’s principle outlet serving the biomedical optics community\, and has co-chaired the leading annual conference in Optical Coherence Tomography (at SPIE’s Photonics West) for two decades. Professor Izatt has worked with multiple companies to license commercial technologies related to optical biomedical imaging\, including co-founding Bioptigen\, Inc.\, which was acquired by Leica Microsystems in 2015. Dr. Izatt is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, The International Society for Optics and Photonics (SPIE)\, The Optical Society (OSA)\, and the National Academy of Inventors (NAI). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/joseph-a-izatt-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/Izatt.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190603T120000
DTEND;TZID=UTC:20190603T130000
DTSTAMP:20260513T200621
CREATED:20190530T222905Z
LAST-MODIFIED:20190603T232041Z
UID:21513-1559563200-1559566800@leadersinlight.com
SUMMARY:Xueding Wang\, Ph.D.
DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \nLight plus Sound: Photoacoustic Imaging and Treatment\nAbstract\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy\, as well as port-wine stain and cancer. \nBiography\nDr. Xueding Wang is a Professor at the Department of Biomedical Engineering\, University of Michigan\, holding an adjunct Professor position at the Department of Radiology.  Before working as an independent principle investigator\, Dr. Wang received his Ph.D. from Dr. Lihong Wang’s lab at the Dwight Look College of Engineering at Texas A&M University\, and then finished postdoctoral training at the University of Michigan School of Medicine under the guidance of Prof. Paul Carson.  Dr. Wang has extensive experience in optical and ultrasound imaging and treatment system development and adaptation of novel diagnostic and therapeutic modalities to preclinical and clinical settings.  Sponsored by NIH\, NSF\, DoD and other funding agencies\, his research has led to over 110+ peer-reviewed publications.  At the University of Michigan Medical School\, a major part of his research is focused on clinical applications of photoacoustic imaging and therapy\, including those involving arthritis\, prostate cancer\, liver conditions\, breast cancer\, Crohn’s disease\, and eye conditions.  Dr. Wang is the recipient of the Sontag Foundation Fellow of the Arthritis National Research Foundation in 2005\, and the Distinguished Investigator Award of the Academy of Radiology Research in 2013. He is also sitting on the editorial boards of scientific journals including Photoacoustics\, Journal of Biomedical Optics\, Medical Physics\, and Ultrasonic Imaging\, and being the steering committee member of the Journal of Lightwave Technology. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Bernard Choi
URL:https://leadersinlight.com/event/xueding-wang-ph-d-2/
LOCATION:3201 Natural Sciences II
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/Wang-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190530T120000
DTEND;TZID=UTC:20190530T130000
DTSTAMP:20260513T200621
CREATED:20190521T224854Z
LAST-MODIFIED:20190524T003346Z
UID:21472-1559217600-1559221200@leadersinlight.com
SUMMARY:Kishan Dholakia\, PhD
DESCRIPTION:Professor at the University of St Andrews\, Scotland\nHonorary Adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India \nShaped Light for the Future of Biomedical Imaging\nAbstract\nI will review recent progress in various aspects of biomedical imaging at St Andrews in my group that has used innovation in shaping light in both space and time. I will cover the topics of wavelength modulated Raman analysis and digital holographic microscopy which we have used to develop label-free hemograms and studies for detection of phenotypically resistant mycobacterium tuberculosis. The main part of my talk will cover the topic of light sheet imaging with propagation invariant light beams (Airy\, Bessel) that offer excellent prospects for new studies in neuroscience\, developmental biology and histopathology. I will conclude with a novel form of imaging  where we use temporal focusing with single pixel detection for wide field multiphoton imaging at depth without the need to characterize the scattering media. The potential impact of these imaging modalities for disease detection and clinical implementation will be emphasized.  \nBiography\nKishan Dholakia is Professor at the University of St Andrews\, Scotland and an honorary adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India. He works on advanced imaging for neuroscience and cancer diagnosis\, beam shaping and optical manipulation leading a group of around 20 researchers. He has published over 300 journal papers\, has in excess of 26\,000 citations. His work is cited in the Guinness Book of Records 2015. He is a Fellow of the Royal Society of Edinburgh\, OSA and SPIE. In 2016 he won the R.W. Wood Prize of the Optical Society\, in 2017 he won the IOP Thomas Young Medal and Prize and in 2018 was the recipient of the SPIE Dennis Gabor Award. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/kishan-dholakia-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/dholakia.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190528T120000
DTEND;TZID=UTC:20190528T130000
DTSTAMP:20260513T200621
CREATED:20190521T222208Z
LAST-MODIFIED:20190521T223519Z
UID:21462-1559044800-1559048400@leadersinlight.com
SUMMARY:Elizabeth Hillman\, PhD
DESCRIPTION:Professor of Biomedical Engineering and Radiology\nZuckerman Mind Brain Behavior Institute at Columbia University \nUsing Light to Image at the Speed of Life\nAbstract\nLight is uniquely capable of probing and changing the electron and vibrational energy levels of molecules. As a result\, light can be used to spectrally discern a tissue’s chemical composition\, excite activity in a neuron and change the shape of the cornea in laser eye surgery. As lasers\, light-sources\, detectors and cameras continue to improve\, the opportunities to leverage the power of light for biomedical discovery\, diagnosis and treatment are continually expanding.\nAn area of enormous growth in the past decade has been the development of fluorescent protein-based reporters of cellular activity and optogenetics\, which combined have unlocked our ability to observe and manipulate cell signaling across scales. The result is a rich and expanding toolkit for studying how intact\, living organs\, organoids and organisms function\, and how they are affected by disease\, which in turn is fueling revolutions in neuroscience\, drug discovery\, personalized medicine. However\, a major bottleneck for these techniques is imaging speed. We developed swept confocally aligned planar excitation (SCAPE) microscopy to address this need for speed\, enabling 3D imaging in living tissues at over 100 volumes per second. SCAPE combines the high signal to noise and low photobleaching benefits of light sheet imaging with confocal descanning principles that enable high-speed scanning through a simple single\, stationary objective lens. Through diverse collaborations\, we have demonstrated SCAPE’s ability to image cellular activity in a wide range of living organisms including freely crawling Drosophila larvae\, the whole brain of behaving adult Drosophila\, zebrafish brain and heart\, 3D culture systems and the awake mouse cortex. We are now developing a range of new SCAPE systems including two-photon\, higher resolution and meso-scale versions\, as well as platforms for high-throughput and high-content imaging of cleared and expanded tissues\, and a miniaturized version of SCAPE for in-situ histopathology for clinical surgical guidance.\nSCAPE is one example of our innovations that have continually sought to leverage the power of light to capture in-vivo dynamics. In parallel we have developed image analysis methods for spatiotemporal and hyperspectral unmixing enabling us to relate complex multidimensional observations to physiological phenomena and behavior. We are applying these tools in our own studies of real-time brain-wide neural activity\, and to explore the relationship between blood flow and neural activity in the brain\, seeking biomarkers and therapeutic targets for neurovascular dysfunction.  \nBiography\nDr Elizabeth Hillman is a Professor of Biomedical Engineering and Radiology\, and a member of the Zuckerman Mind Brain Behavior Institute at Columbia University. Dr Hillman completed her undergraduate degree in Physics\, and PhD in Medical Physics and Bioengineering at University College London. After a year at a Boston medical device start-up company\, Dr Hillman completed postdoctoral training at the Martinos center for Biomedical Imaging at Massachusetts General Hospital / Harvard Medical School before becoming faculty at Columbia University in 2006. Prof Hillman has developed a range of novel approaches to in-vivo optical imaging and microscopy for both clinical and research applications. Her PhD work focused on time-resolved diffuse optical tomography of the breast and premature infant brain\, while her innovations since have included Dynamic Contrast enhanced molecular imaging (DyCE\, licensed to CRi Inc\, now PerkinElmer)\, Laminar Optical Tomography for brain and skin imaging\, hyperspectral two-photon microscopy\, wide-field optical mapping (WFOM) of neuronal activity and hemodynamics and most recently high-speed 3D swept confocally aligned planar excitation (SCAPE) microscopy (now licensed to Leica Microsystems). Continuing technology development includes new variants of SCAPE including a miniaturized clinical version for ‘real-time’ intrasurgical in-situ histopathology. Dr Hillman also has an active research program applying her in-vivo imaging tools to studying neurovascular coupling and brain-wide resting state neural activity dynamics in the healthy\, diseased and developing rodent brain. Dr Hillman has developed educational programs at Columbia University focusing on Disruptive Biomedical Design\, Biomedical Imaging and Advanced Microscopy. She is a Fellow of the OSA\, SPIE and AIMBE\, and her awards include an NSF CAREER Award in 2010\, the 2011 Optical Society of America Lomb Medal for contributions to optics at a young age\, and the SPIE Biophotonics Technology Innovator award in 2018.  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/elizabeth-hillman-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/hillman_UCI.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190516T120000
DTEND;TZID=UTC:20190516T130000
DTSTAMP:20260513T200621
CREATED:20190201T024715Z
LAST-MODIFIED:20190516T224250Z
UID:7506-1558008000-1558011600@leadersinlight.com
SUMMARY:Alon Gorodetsky\, PhD
DESCRIPTION:UC Irvine Assoc. Professor\nDepartment of Chemical Engineering and Material Sciences \nDynamic Materials Inspired By Cephalopods\nAbstract\nCephalopods (squid\, octopuses\, and cuttlefish) have captivated the imagination of both the general public and scientists alike for more than a century due to their visually stunning camouflage displays\, sophisticated nervous systems\, and complex behavioral patterns. Given their unique capabilities and characteristics\, it is not surprising that these marine invertebrates have emerged as exciting models for novel materials and systems. Within this context\, our laboratory has developed various cephalopod-derived and cephalopod-inspired materials with unique functionalities.  Our findings hold implications for next-generation adaptive camouflage devices\, sensitive bioelectronic platforms\, and advanced renewable energy technologies. \nBiography\nDr. Alon Gorodetsky is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the University of California\, Irvine\, with joint appointments in the Department of Chemistry and the Department of Materials Science and Engineering. Dr. Gorodetsky obtained B.S. degrees in Engineering Physics and Materials Science at Cornell University and a Ph.D. in Chemistry at the California Institute of Technology. He subsequently completed postdoctoral work as a National Science Foundation American Competitiveness in Chemistry Fellow at Columbia University. His current research is focused on the development of macromolecular and biomolecular materials inspired by natural systems\, with an emphasis on cephalopods. His work has been featured in Popular Science\, Popular Mechanics\, Newsweek\, The Telegraph\, Wired\, The Verge\, Fox News\, NPR Marketplace\, BBC World\, CNN and other popular media. For his studies\, Dr. Gorodetsky has received several awards\, including the Henry Samueli School of Engineering Mid-Career Faculty Excellence in Research Award\, Applied Innovation Early Career Innovator of the Year Award\, the AFOSR Young Investigator Award\, the DARPA Young Faculty Award with the Director’s Option\, and the Presidential Early Career Award for Scientists and Engineers. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/alon-gorodetsky-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2019/01/alon-gorodetsky.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190513T121500
DTEND;TZID=UTC:20190513T131500
DTSTAMP:20260513T200621
CREATED:20190503T001639Z
LAST-MODIFIED:20190503T010125Z
UID:21411-1557749700-1557753300@leadersinlight.com
SUMMARY:Brian W. Pogue\, Ph.D.
DESCRIPTION:MacLean Professor of Engineering\, Dartmouth\nEditor-in-Chief\, Journal of Biomedical Optics\, SPIE Press \nImaging Medicine\nAbstract\nWhile the field of Medical Imaging is dominated by radiological devices\, the field of Imaging Medicine today is dominated by optical devices.   Optical imaging is commonly used at the point-of-care\, where patient and physician are in the same room together.  These procedure-based tools are used to capture unique contrast features that help guide medical decisions. In the Optics in Medicine cluster at Dartmouth scientific discovery and technology development are advanced side-by-side in areas such as image-guided spectroscopy of cancer\, surgical guidance tools with molecular specificity\, smart photodynamic therapy\, and novel radiologic guidance and dosimetry tools for remote non-contact monitoring of Cherenkov and scintillation light.  Examples from each will be used to highlight innovations in translational research that have gone from scientific concept through to technology development and into clinical trials.  Translating optical Imaging systems beyond the pilot trial phase involves the type of R&D which only companies can accomplish\, and so examples of strategic partnerships with companies in translational research will be shown.  Venture creation through a startup company\, DoseOptics LLC\, will be highlighted in which this pathway has enabled testing and deployment of a fundamentally new technology to image radiation dose delivery in real time for the first time in history\, and extended to multiple cancer centers. The invention and translation of new optical tools to Image Medicine is an enormous economic force today\, and the growth in science and technology opportunities and NIH funding within this field is discussed. \nBiography\nBrian W. Pogue\, Ph.D. is the MacLean Professor of Engineering at Dartmouth in Hanover\, New Hampshire USA\, and is Adjunct Professor in Surgery at the Geisel School of Medicine and Adjunct Professor of Life Science & Technology at Xi’an Jiaotong University\, China.  His Doctoral work in Physics from McMaster University\, Canada\, was followed by a Research Fellow position at the Wellman Center for Photomedicine at Harvard Medical School.  At Dartmouth since 1996\, he works in the area of Optics in Medicine\, with a focus on novel imaging systems for characterizing cancer and tracking therapy. Following being Dean of Graduate Studies at Dartmouth from 2008-2012\, he is now Director of MS and PhD Programs in Engineering Science & Medical Physics and coordinates the Center for Imaging Medicine.  He has published over 350 peer-reviewed papers and 400 conference papers in cancer therapy\, surgery\, medicine\, medical oncology\, and radiotherapy.  His research is funded by the NIH through two Program Project grants as well as several individual R01 grants. He is the Editor-in-Chief of the Journal of Biomedical Optics published by SPIE and is a Fellow of the International Society for Optics and Photonics (SPIE)\, the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineers (AIMBE).  He recently founded the startup company DoseOptics LLC\, making the world’s first camera to image radiotherapy dose delivery. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner
URL:https://leadersinlight.com/event/brian-pogue-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/BrianPogue.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190425T120000
DTEND;TZID=UTC:20190425T130000
DTSTAMP:20260513T200621
CREATED:20190125T041910Z
LAST-MODIFIED:20190404T234907Z
UID:7355-1556193600-1556197200@leadersinlight.com
SUMMARY:Xiaolin Nan\, PhD
DESCRIPTION:Department of Biomedical Engineering\nOregon Health & Sciences University\nPortland\, Oregon \nVisualizing Tumor Biology: From Single Molecules to Systems\nCancer is a systems disease that arises from complex molecular abnormalities\, whereby effective treatment requires insight into tumorigenesis at multiple levels – from individual molecules to whole cells and tumors. Research in our laboratory aims to build multiscale\, systems-level models of tumorigenic signaling by leveraging recent developments in single-molecule\, superresolution\, and correlative light – electron microscopies. Using the human epidermal growth factor receptors (e.g. HER2) and the Ras small GTPases as model systems\, we will showcase how quantitative imaging at the single-molecule and nanometer scales reveals previously unknown aspects of these common oncogenic drivers. These findings underscore the importance of studying tumor biology within the intact spatial and biological context\, which current omics-based systems-biology approaches have largely overlooked. We will also discuss ongoing efforts toward constructing spatially-integrated models of tumorigenic signaling networks through multiplexed and high-throughput superresolution imaging\, as well as the implications of our findings in targeted cancer therapies. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Eric Potma
URL:https://leadersinlight.com/event/xiaolin-nan-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/01/nan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190404T120000
DTEND;TZID=UTC:20190404T130000
DTSTAMP:20260513T200621
CREATED:20190125T025111Z
LAST-MODIFIED:20190227T084914Z
UID:7423-1554379200-1554382800@leadersinlight.com
SUMMARY:Vincent Daria\, PhD
DESCRIPTION:Applied Physics\nFellow\, Group Leader (Neuro-photonics Group)\nANU College of Health and Medicine\nAustralian National University Canberra\, AU \n  \nUsing Complex Light Patterns To Understand Brain Circuits\nWe aim to understand how information is processed in cortical circuits of the mammalian brain.  To achieve this\, we use complex light patterns to stimulate and record the activity of single cortical neurons in a rat brain slice.  We use holographic projection of an ultrafast laser to produce multiple foci\, where each focus emulates a synaptic input or an optical recording probe. To emulate synaptic inputs\, multiple foci are directed onto spines of a neuron and gated illumination enables localized two-photon (2P) photolysis of caged neurotransmitters. Patterned spatio-temporal release of neurotransmitters onto multiple spines allows us to study the input-output characteristics of single neurons in the cortex. As an optical recording probe\, each focus excites neuronal activity reporters via 2P multi-foci excitation.  The fluorescence emanating from all foci are simultaneously recorded using an electron-multiplying charge-coupled device (EMCCD) camera thereby enabling simultaneous multi-channel recording of the neuronal activity from multiple sites.  We report recording of neuronal activity from two types of reporters: (1) calcium indicator\, Cal520; and (2) voltage indicator\, JPW1114.  We optically recorded the activity evoked by the neuron following injection of current onto the soma. Using this technique\, we have uniquely identified a crucial function of a specific set of dendrites for learning and memory. Moreover\, we can disable such function by prunning the specific dendrite via highly targetted femtosecond laser dendrotomy. Using complex light patterns to understand the input-output transfer function of single neurons enables bottom-up approach to understand information processing in the brain. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Daryl C Preece
URL:https://leadersinlight.com/event/vincent-daria-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/01/daria.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190327
DTEND;VALUE=DATE:20190401
DTSTAMP:20260513T200621
CREATED:20190127T000808Z
LAST-MODIFIED:20190201T024816Z
UID:7449-1553644800-1554076799@leadersinlight.com
SUMMARY:ASLMS 2019
DESCRIPTION:Hear why you can’t miss ASLMS 2019. \nDenver\, Colorado March 27 -31\, 2019. Visit http://www.aslms.org/annual-conference-2019 to register.
URL:https://leadersinlight.com/event/aslms-2019/
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2019/01/FPEFtfga_400x400.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190315T140000
DTEND;TZID=UTC:20190315T150000
DTSTAMP:20260513T200621
CREATED:20190221T063747Z
LAST-MODIFIED:20190221T064525Z
UID:20982-1552658400-1552662000@leadersinlight.com
SUMMARY:Xueding Wang\, Ph.D.
DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \n  \nLight plus Sound: Imaging and Treatment\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy. \n  \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. \nHosted by Dr. Zhongping Chen
URL:https://leadersinlight.com/event/xueding-wang-ph-d/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/Wang-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190220T123000
DTEND;TZID=UTC:20190220T133000
DTSTAMP:20260513T200621
CREATED:20190214T091649Z
LAST-MODIFIED:20190215T020121Z
UID:12372-1550665800-1550669400@leadersinlight.com
SUMMARY:Logan Swartz\, PhD
DESCRIPTION:Liu Group\, UC Davis \nScanning Probe Microscopy Based 3D Nanolithography\nThree dimensional (3D) printing has been an active area of research and development due to its capability to produce 3D objects by design.  Miniaturization and improvement of spatial resolution are major challenges in current 3D printing technology development.  This presentation reports advances in bringing 3D nanolithography to the nanometer scale using scanning probe microscopy (SPM).  SPM uses nanometer scale sharp tips to probe localized tip material interactions at the atomic and/or molecular level.  Taking advantage of the interactions to instead print materials\, in conjunction with SPM’s nanometer precision piezo based positioning systems and local surface chemistry\, we have been able to develop methods to advance 3D printing to 3D nanolithography/nanoprinting. \nThree methods were developed.  The first presented culminated in the first patented\, 3D nanoprinter.  It involves directly delivering polyelectrolyte complex materials layer-by-layer using an atomic force microscopy (AFM) probe.  This enabled creation of 3D nanostructures with nanometer precision in all three dimensions.  The second method describes development of a new technique for near-field scanning optical microscopy (NSOM) nanolithography.  NSOM lithography uses an SPM probe as a local light source to break the diffraction limit to perform photolithography.  We have created new versions of these probes by developing ways to attach fluorescent nanoparticles to the end of AFM probes.  The third method is a convenient way to modify with in situ control AFM probes to have a flat surface/plateau at their end.  These plateau probes\, mounted on an AFM\, are useful for compression studies to measure the created nanostructures’ nanomechanical properties. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Michael Berns
URL:https://leadersinlight.com/event/logan-swartz-phd/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/Logan-Swartz.jpg
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DTSTART;TZID=UTC:20190219T100000
DTEND;TZID=UTC:20190219T110000
DTSTAMP:20260513T200621
CREATED:20190219T104205Z
LAST-MODIFIED:20190220T005029Z
UID:20146-1550570400-1550574000@leadersinlight.com
SUMMARY:Junle Qu\, Ph.D
DESCRIPTION:Professor of Optical Engineering\nShenzhen University \nSuper-resolution for live cell imaging\nSuper-resolution imaging has made remarkable progress in recent years\, providing a powerful tool for biology. It allows for the observation of fine structures of cells\, cellular dynamics and cellular functions at nanometer scale or even single molecular level\, which greatly promotes the development of life science and many other fields. In this talk I will present our recent work in super-resolution optical microscopy. By combining stimulation emission depletion (STED) microscopy and fluorescence lifetime imaging (FLIM)\, we can improve the spatial resolution of STED and perform FLIM imaging at nanometer resolution. Novel fluorescent probes with low STED laser power and experiment strategies were designed for live cell mitochondria imaging. Coherent adaptive optical technique (COAT) has been implemented in STED microscope to circumvent the scattering and aberration effect for thick sample imaging. Stochastic optical reconstruction microscopy (STORM) superresolution imaging of mitochondrial membrane in live cells was achieved by the development of new fluorescent probes\, improved imaging system and optimized single molecule localization algorithm. These developments make it possible to study dynamic events and complex functions in living cells\, even with a single conventional microscope. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen
URL:https://leadersinlight.com/event/junle-qu/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/Junle-Qu.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20190208T120000
DTEND;TZID=UTC:20190208T130000
DTSTAMP:20260513T200621
CREATED:20190202T034746Z
LAST-MODIFIED:20190202T042038Z
UID:7530-1549627200-1549630800@leadersinlight.com
SUMMARY:Inga Saknite\, PhD
DESCRIPTION:Vanderbilt Translational Skin Imaging Clinic\nVanderbilt University Medical Center \nLeukocyte dynamics in human skin capillaries by noninvasive reflectance confocal microscopy\nInflammatory tissue response is one of the first and most common manifestations of acute graft-versus-host disease (aGVHD)\, a potentially deadly immune-mediated disease that occurs in 30-60% of patients after hematopoietic stem cell transplantation. A fundamental challenge in developing effective treatment strategies for aGVHD is the lack of tools to study disease biology in real-time in post-transplant patients. The inflammatory tissue response causes increased expression of specialized endothelial proteins on vessel walls making leukocytes to roll\, adhere and eventually extravasate into the tissue at a higher rate than in normal conditions. Although the importance of leukocyte-endothelial interactions to detect and track inflammation has been well shown in murine models\, there are no published clinical studies in humans. In this study\, we explore the feasibility to detect presence of aGVHD in post-transplant patients through the imaging of in vivo leukocyte motion. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Mihaela Balu
URL:https://leadersinlight.com/event/inga-saknite/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/inga.jpg
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