BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Beckman Laser Institute - ECPv6.16.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Beckman Laser Institute X-ORIGINAL-URL:https://leadersinlight.com X-WR-CALDESC:Events for Beckman Laser Institute REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:UTC BEGIN:STANDARD TZOFFSETFROM:+0000 TZOFFSETTO:+0000 TZNAME:UTC DTSTART:20180101T000000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=UTC:20201119T120000 DTEND;TZID=UTC:20201119T133000 DTSTAMP:20260513T181604 CREATED:20201117T045353Z LAST-MODIFIED:20201120T071341Z UID:28928-1605787200-1605792600@leadersinlight.com SUMMARY:Muyinatu Bell.\, Ph.D. DESCRIPTION:Assistant Professor & PULSE Lab Director – Johns Hopkins University \nDepartment of Electrical and Computer Engineering\nDepartment of Biomedical Engineering \nListening to the Sound of Light to Guide Surgeries \nAbstract\nPhotoacoustic imaging offers “x-ray vision” to see beyond tool tips and underneath tissue during surgical procedures\, yet no ionizing x-rays are required. Instead\, optical fibers and acoustic receivers enable photoacoustic sensing of major structures – like blood vessels and nerves – that are otherwise hidden from view. The entire process is initiated by delivering laser pulses through optical fibers to illuminate regions of interest\, causing an acoustic response that is detectable with ultrasound transducers. Beamforming is then implemented to create a photoacoustic image. In this talk\, I will highlight novel light delivery systems\, new spatial coherence beamforming theory\, deep learning alternatives to beamforming\, and robotic integration methods\, each pioneered by the Photoacoustic & Ultrasonic Systems Engineering (PULSE) Lab to enable an exciting new frontier of photoacoustic-guided surgery. This new paradigm has the potential to eliminate the occurrence of major complications (e.g.\, excessive bleeding\, paralysis\, accidental patient death) during a wide range of delicate surgeries and procedures\, including neurosurgery\, cardiac catheter-based interventions\, liver surgery\, spinal fusion surgery\, hysterectomies\, biopsies\, and teleoperative robotic surgeries. \nBiography\nMuyinatu Bell is an Assistant Professor of Electrical and Computer Engineering\, Biomedical Engineering\, and Computer Science at Johns Hopkins University\, where she founded and directs the Photoacoustic and Ultrasonic Systems Engineering (PULSE) Lab. Dr. Bell earned a B.S. degree in Mechanical Engineering (biomedical engineering minor) from Massachusetts Institute of Technology (2006)\, received a Ph.D. degree in Biomedical Engineering from Duke University (2012)\, conducted research abroad as a Whitaker International Fellow at the Institute of Cancer Research and Royal Marsden Hospital in the United Kingdom (2009-2010)\, and completed a postdoctoral fellowship with the Engineering Research Center for Computer-Integrated Surgical Systems and Technology at Johns Hopkins University (2016). She is Associate Editor-in-Chief of IEEE Transactions on Ultrasonics\, Ferroelectrics\, and Frequency Control (T-UFFC)\, Associate Editor of IEEE Transactions on Medical Imaging\, and holds patents for short-lag spatial coherence beamforming and photoacoustic-guided surgery. She is a recipient of multiple awards and honors\, including MIT Technology Review’s Innovator Under 35 Award (2016)\, the NSF CAREER Award (2018)\, the NIH Trailblazer Award (2018)\, the Alfred P. Sloan Research Fellowship (2019)\, the ORAU Ralph E. Powe Jr. Faculty Enhancement Award (2019)\, and Maryland’s Outstanding Young Engineer Award (2019). She most recently received the inaugural IEEE UFFC Star Ambassador Lectureship Award (2020) from her IEEE society. \n  \nREGISTER HEREDr. Muyinatu Bell\, Ph.D. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/muyinatu-bell-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/11/MuyinatuBell.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20201105T120000 DTEND;TZID=UTC:20201105T130000 DTSTAMP:20260513T181604 CREATED:20200916T002616Z LAST-MODIFIED:20201013T002524Z UID:27835-1604577600-1604581200@leadersinlight.com SUMMARY:Stefan M. Cooper\, Jr.\, Ph.D. DESCRIPTION:Assistant Professor of Chemistry- Alcorn State University \nDepartment of Chemistry and Physics \nAzo and Hydrazone Molecular Photoswitches’ Photoinduced Conformational Adjustability Exploited for a Light-Enabled Template for Site-Selective Arene C-H Bond Functionalization \nAbstract\nSite-Selectivity is highly desired for work in C-H bond functionalization as organic framework are typically saturated with C-H bonds of similar reactivity. Differentiating selectivity for a single desired C-H bond among a plethora of other similar C-H bonds is a daunting task. Template guided C-H bond functionalization has recently emerged as a solution to pursuits in site-selectivity. Key to this strategy is the strategic molecular shape of the template that affords advantageous intramolecular distances between a coordinated metallic catalyst (on the template) with a desired C-H bond (from a covalently attached substrate). We seek to contribute with the creation of a novel light-enabled template. This template anticipates affording opportunities in varied site-selectivity that is toggled by wavelength modulation. Our envisioned template is based on two initial molecular photoswitch framework: azo and hydrazone functionalities. Photoisomerization affords a “T-shape” conformation for azoheteroarenes that is exploited for remote site-selectivity. Equally\, photoisomerization of the hydrazone scaffold affords a key molecular rotation exploited for varied site-selectivity. The aforementioned work is proposed in for initiating an undergraduate research program in chemistry at a Historical Black University\, Alcorn State University. \nBiography\nStefan Malone Cooper\, Jr. obtained his B.S. in chemistry from the College of Charleston (Charleston\, SC) in 2007. There he worked\, as an undergraduate researcher\, on creating derivatives of the antibiotic\, Cytosporone E\, advised by Dr. Justin Wyatt. Later in 2015\, Stefan obtained a Ph.D. in Organic Chemistry advised by Dr. William E. Crowe. His dissertation was entitled “TRANS-POSITIONING” CARBONS WITHIN STRAINED CAGED BICYCLIC(S): ROM/RCM (RING-OPENING/RING-CLOSING METATHESIS AND DIECKMANN CONDESATION ROUTES TO A CIS-DECALIN INFRASTRUCTURE. Stefan complete a short stint as a postdoctoral researcher in the lab Dr. Herman Sintim in 2015\, at the University of Maryland and later was appointed in 2016 as a Path to Professoriate Fellow within Hampton’s University NSF Partnership for Research and Education in Material (PREM). Stefan was appointed as an assistant professor in the department of Chemistry and Physics at Alcorn State University\, Fall 2017. \n  \nREGISTER HERE: https://us02web.zoom.us/meeting/register/tZcudOyqrzMpG9dhBQnU8taUOUW-u6W_low9 \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/stefan-m-cooper-jr-phd/ LOCATION:Zoom Event\, CA\, United States ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/09/cooper-192x192-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20201015T120000 DTEND;TZID=UTC:20201015T130000 DTSTAMP:20260513T181604 CREATED:20201007T034433Z LAST-MODIFIED:20201013T002714Z UID:28827-1602763200-1602766800@leadersinlight.com SUMMARY:Niklas Hedde\, Ph.D. DESCRIPTION:University of California\, Irvine – Pharmaceutical Sciences\nLaboratory for Fluorescence Dynamics \nOptical Detection of Rare Space Time Events for Precision Medicine \nAbstract\nFinding low-abundance bioparticles and rare events in clinically relevant samples is an unresolved but very important issue in biomedicine\, specifically for rapid identification of infections and malignant tissues and the development of personalized cancer immunotherapeutics. Optical methods are minimally invasive and have the potential to identify targets and screen large samples within short periods of time with the capability to enable detailed analyses. \nHigh resolution quantification of rare interactions including immune cell interactions and circulating tumor cells invading healthy tissues could significantly advance the development of precision medicine treatments and personalized therapeutics. For this purpose\, we are developing an intelligent\, high throughput light sheet microscopy platform that can screen large complex structures in physiologically relevant 3D cell/tissue culture models and patient derived organoids. While nanoscale imaging with millisecond time resolution can map the dynamic spatial organization of biomolecules\, the same platform enables hyperspectral and fluorescence lifetime-based metabolic imaging. This technology has the potential to study treatment effectiveness in patient derived tissues/organoids to develop highly personalized therapeutics for cancer treatment. \nAt the same time\, rapid and accurate optical identification of viruses and bacteria in fluids and on surfaces could significantly advance diagnosis of infectious diseases\, detect contaminants in medical supplies\, identify circulating tumor cells\, and discover antibody-producing B cells and antigen-specific T cells\, to name a few. Existing biochemical or microfluidic methods take many hours or are not sensitive enough to detect highly dilute\, single targets. To address this issue\, we are developing a revolutionary 3D particle detection approach to find and isolate rare targets (1-100 per mL) directly from larger volumes of fluid (1-10 mL) within minutes. \nBiography\nPer Niklas Hedde\, Ph.D.\, is a researcher at the University of California\, Irvine where he develops camera-based fluorescence fluctuation spectroscopy techniques\, devices for the isolation of rare bioparticles from turbid media\, and optical methods for medical diagnosis and antibody discovery using non-linear excitation with lifetime and hyperspectral detection. He studied physics at the University of Ulm\, Germany\, with a master thesis project on ultrafast analysis of super-resolution microscopy data. He completed his Ph.D. in physics at the Karlsruhe Institute of Technology where he built an instrument for super-resolved image correlation spectroscopy to study the dynamics of cell membrane receptors and developed localization microscopy techniques to image protein mutations and receptor interactions related to heart disease and allergy. For his thesis work he received the Karlsruhe Institute of Technology Award for Outstanding Doctoral Research Work in the Area of Applied Life Sciences 2014 and the Gregorio Weber International Prize 2014. He then accepted a postdoctoral position at the Laboratory for Fluorescence Dynamics at UC Irvine to broaden his skills including fluorescence lifetime\, spectral and polarization imaging. During this time\, he also visited and collaborated with the Karolinska Institute in Stockholm\, Sweden to learn about natural killer cells\, their value for cancer immune therapy and to establish fluctuation spectroscopy methods at the KI Department of Microbiology\, Tumor and Cell Biology. So far\, he has published 30 peer-reviewed journal articles and is member of the Biophysical Society (US and Germany)\, the American Association for Cancer Research\, and the UC Irvine Center for Complex Biological Systems. Most recently\, he received an R21 award from NIH for the development of “Fluctuation Spectroscopy with Light Sheet Microscopy”. \n  \nREGISTER HERE: https://us02web.zoom.us/meeting/register/tZwudeqhrjwtHNYaqYT7RSFNQKVOZJZ5uY9Z \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/niklas-hedde-ph-d/ LOCATION:Zoom Event\, CA\, United States ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/09/pnhedde.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200623T080000 DTEND;TZID=UTC:20200623T090000 DTSTAMP:20260513T181604 CREATED:20200623T050228Z LAST-MODIFIED:20200623T051025Z UID:28447-1592899200-1592902800@leadersinlight.com SUMMARY:VBF Facebook Live Discussion DESCRIPTION:Topic: Port Wine stains & Hemangiomas during COVID-19 \nFaceBook Link: VascularBirthmarksFoundation\n\n\n\nThis is a free event. URL:https://leadersinlight.com/event/vbf-facebook-live-discussion/ LOCATION:FaceBook Live\, CA\, United States CATEGORIES:Symposium ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/06/VBF-JSNELSON-2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200508T080000 DTEND;TZID=UTC:20200508T170000 DTSTAMP:20260513T181604 CREATED:20200501T234125Z LAST-MODIFIED:20200509T034221Z UID:28095-1588924800-1588957200@leadersinlight.com SUMMARY:Brain & Kidney Symposium DESCRIPTION:  \nThe Department of Veterans Affairs\, Employee Education System\, 10P11 – Specialty Care Services & Neurology jointly provided with the UCI School of Medicine Presents: \n\n\nThe 2020 Brain & Kidney Symposium\n\n\nPlease join us for the world’s first all-day virtual International Conference highlighting the interface between neuroscience\, neurology\, and nephrology. The multidisciplinary panel of speakers and moderators includes experts from the fields of neurology\, nephrology\, pathology\, and psychiatry.  Up to 7.0 CME credits will be available. \n\n\n\nLecture Topics include: \n\nAnatomical and Physiological Considerations for the Brain-Kidney Axis\, including the Basics of Chronic Kidney Disease (CKD)\nCerebral Blood Flow\, Neuropathology\, and  Microvascular Disease in CKD\nCKD and Dementia\, Epilepsy\, Movement and Sleep Disorders\, and in the Neuro-ICU\nStroke Epidemiology\, Prevention\, and Treatment in CKD\nNeuroimaging\, Dietary Issues\, and Fabry Disease in the Brain-Kidney Axis\n\nThis is a free event.\nZoom link: https://zoom.us/j/401668288\nPASSWORD:  503699\nAttendees must Register to receive post-event link to request CME.\n\n  \nFor more information\, contact Kristine Fuentebella at kfuenteb@uci.edu or 714-456-5142. URL:https://leadersinlight.com/event/brain-and-kidney-symposium/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:Symposium ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2020/05/Brain-Kidney-Symposium.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200227T120000 DTEND;TZID=UTC:20200227T130000 DTSTAMP:20260513T181604 CREATED:20200212T024829Z LAST-MODIFIED:20200212T025402Z UID:27789-1582804800-1582808400@leadersinlight.com SUMMARY:Dr. Vivek Jay Srinivasan DESCRIPTION:Associate professor of Biomedical Engineering and Ophthalmology at the University of California\, Davis \nHuman Brain Interferometers for Better Blood Flow Monitoring \nAbstract \nSteady cerebral blood flow (CBF) is needed for normal brain function\, but continuous monitoring of CBF in humans is currently challenging.  Here\, by leveraging a low-cost sensor technology\, we introduce a class of novel near-infrared optical devices that monitor CBF continuously and non-invasively in adult humans.  We achieve this by replacing expensive single photon counting detectors\, currently used for optical CBF monitors\, with complementary metal–oxide–semiconductor (CMOS) arrays. We maintain performance by employing an additional optical “trick” known as interferometry\, which transforms each CMOS pixel into a sensitive detector for fluctuations of coherent light that probes blood flow in the brain.   Our method is called interferometric Diffusing Wave Spectroscopy (iDWS).  Since CMOS camera pixels are cheap and numerous\, iDWS both improves the performance and reduces the cost of optical CBF monitoring\, enabling record brain-to-scalp sensitivity. By liberating CBF monitoring from photon counting\, iDWS enables measuring CBF continuously in a new environments. In this talk we describe technical advantages of iDWS relative to conventional methods\, and broadly envisage how interferometry can help to advance the field of diffuse optics. \nBiography \nVivek Srinivasan is Associate Professor of Biomedical Engineering and Ophthalmology and Chancellor’s Fellow at UC Davis. His group develops new light-based technologies for in vivo imaging and sensing of the brain and eye.  Starting with a firm grounding in neurophysiology and biomedical engineering\, his group employ ideas novel photonic technologies and approaches to accomplish this goal. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Bernard Choi URL:https://leadersinlight.com/event/vivek-srinivasan/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/02/Vivek.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200213T123000 DTEND;TZID=UTC:20200213T133000 DTSTAMP:20260513T181604 CREATED:20200206T024504Z LAST-MODIFIED:20200206T024504Z UID:27752-1581597000-1581600600@leadersinlight.com SUMMARY:The Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques DESCRIPTION:Woonggyu Jung\, Ph. D. \nUlsan National Institute of Science and Technology\, Korea \nThe Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques\n  \nAbstract \nThe histological optical imaging is a gold standard method to observe the biological tissues\, which follows routine process such as dissection\, embedding\, sectioning\, staining\, visualization and interpretation of specimens. This technique has a long history of development\, and is used ubiquitously in pathology\, despite being highly time and labour-intensive. Advanced optical imaging techniques developed over the last decade have enabled to provide high sensitivity\, high resolution and non-invasive biological information. However\, acquiring high throughput\, large volume tissue anatomy remains a difficult challenge due to the effect of light scattering\, which limits the penetration imaging depth and lateral resolution. Recently\, various optical imaging methods have been introduced to create volumetric anatomy data of ex vivo tissues using physical tissue sectioning or optical clearing. Even though these new approaches present the distinguished volumetric anatomy in various scales\, they are still not suitable for use in statistical studies with multiple tissues and organs. Here\, we introduce novel label-free and multi-scale imaging modality based on serial optical coherence microscopy (OCM). OCM is a potential technique to build volumetric anatomy of mouse tissues or organs due to its simplicity\, efficiency\, robustness\, and high-throughput capabilities. This presentation covers the latest work of large-scale brain and kidney imaging using OCM and its potential in bio-applications. Specifically\, the talk will highlight other label-free optical imaging modalities including wide-field quantitative phase microscopy and optical projection tomography toward to multi-scale histopathology. \nBiography \nWoonggyu Jung received his Ph. D. in 2008 from the Department of Biomedical Engineering at the University of California\, Irvine. From 2001 to 2008\, he worked at the Beckman Laser Institute and Medical Clinic at UC Irvine. He also worked at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign since January 2009. He has joined the faculty of UNIST in 2012\, and currently works as an associate professor of Department of Biomedical Engineering. He is also co-founder and CTO of start-up company\, Conecson which is focused on the futuristic business regarding to mobile-based medical devices. Dr. Jung has a strong research background in optical imaging technologies including optical coherence tomography (OCT)\, quantitative phase microscope (QPM)\, and miniaturized optical imaging probes. His research interest is to develop new optical technologies that address challenges in clinical medicine\, basic biological research and neuroscience. In previous work\, he developed a successful optical platform for in vivo translational research\, and has published more than 60 peer-reviewed journal papers in the field of biophotoics. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Zhongping Chen URL:https://leadersinlight.com/event/woonggyu-jung/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/02/Woonggyu-Jung.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200210T120000 DTEND;TZID=UTC:20200210T130000 DTSTAMP:20260513T181604 CREATED:20200111T051746Z LAST-MODIFIED:20200111T073656Z UID:27661-1581336000-1581339600@leadersinlight.com SUMMARY:Professor Alfred Vogel DESCRIPTION:Institute of Biomedical Optics\, University of Lüebeck\, Germany \nFree-electron-mediated modifications of biomolecules: from photodamage in nonlinear microscopy to intentional photomodification of cells and tissues \n\nAbstract\nFemtosecond laser-induced plasma generation is used surgically and may also cause photodamage in nonlinear microscopy. The irradiance threshold at which transient vapor bubbles in water are produced by single pulses is 20 times higher than the irradiance used for microscopy. However\, photodamage in multiphoton microscopy already starts\, when the irradiance is raised 1.5 times above the value used for autofluorescence imaging. The huge realm of low-density plasma effects between multi-pulse nonlinear imaging and single-pulse surgical regime is little explored. We provide a systematic overview over irradiance and radiant exposure dependence of laser effects in this regime. Surgery by single-pulses relies on the disruptive effect of nm to µm sized transient cavitation bubbles. The threshold is here determined by a critical temperature above which a phase transition occurs. Series of low-energy fs pulses induce free-electron mediated modifications and finally disintegration of biomolecules. Bubble here contain non-condensable gas rather than water vapor. The underlying process is a nonlinear chemical rate process\, and threshold characteristics differ fundamentally from the single-pulse threshold. Below bubble threshold\, photomodifications can be utilized to create corneal refractive changes suitable for non-ablative treatment of myopia and hyperopia. Photodamage in multiphoton microscopy was explored for various cell types and tissues using physical indicators enabling real-time-monitoring of the damage kinetics. We characterize the transition from unchanged tissue (emitting autofluorescence) to slightly changed tissue (hyperfluorescence)\, drastically changed tissue (plasma luminescence) and finally molecular disintegration leading to gas bubble formation. By plotting the threshold values in (irradiance\, radiant exposure) space\, we can clearly identify a “safe” region for nonlinear microscopy and separate it from regions for different types of photomodification. \nBiography\nProf. Alfred Vogel is Team Leader and former Director of the Institute of Biomedical Optics (BMO)\, University of Luebeck\, Germany. Hereceived the Ph.D. degree in Physics from University Goettingen in 1987\, and the degree of Habilitated Doctor of Physics from the University of Luebeck\, Germany\, in 1999. Since 2010 he is also Adjunct Professor of Xiʼan Jiaotong University\, PR China. Dr. Vogel is fellow of the Optical Society (OSA) and of SPIE. He has published over 90 peer-reviewed jounral articles and 51 proceedings papers. His published work has received over 12\,000 citations with a h-index of 47. He holds 11 patents.\n Dr. Vogel has made major experimental and theoretical contributions to the field of pulsed laser interactions with molecules\, cells and biological tissues. He developed comprehensive theoretical frameworks for pulsed laser tissue interactions ranging from photochemical changes to ablation\, and for controlled nonlinear energy deposition in transparent dielectrics.\nHe invented new technologies for imaging and characterization of plasmas\, shock waves\, cavitation bubbles\, and ablation plume dynamics. His research encompasses surface ablation through linear absorption of ultraviolet and infrared laser pulses\, ablation processes in a liquid environment such as in blood vessels or joints\, as well as precise plasma-mediated ablation\, surgery\, and molecular modificationswithin nominally transparent materials such as ocular tissues and cells. His work in these areas hasled to innovative strategies for improving cellular micro/nano surgery\, intraocular surgery\,and refractive surgery.\n Dr. Vogel served on the editorial board for the Journal of Biomedical Optics (2002-2019)\, served as associate editor of Optics Express (2006-2009)\, and as advisory editor of Biomedical Optics Express (2010-2019). \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova.\nSponsored by the Berns Family Laser and Microbeam Program URL:https://leadersinlight.com/event/alfred-vogel/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/01/Vogel-Head-Shot.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20200117T120000 DTEND;TZID=UTC:20200117T130000 DTSTAMP:20260513T181604 CREATED:20200111T082429Z LAST-MODIFIED:20200111T082429Z UID:27674-1579262400-1579266000@leadersinlight.com SUMMARY:Dr. James V. Jester DESCRIPTION:Endowed Research Chair and Professor of Ophthalmology and Biomedical Engineering\nUniversity of California\, Irvine \nNon Linear Optical Corneal Collagen Crosslinking (NLO CXL) for Treatment of Refractive Errors\nAbstract\nCorneal collagen crosslinking (CXL) using ultraviolet light (UVA) photoactivation of riboflavin leads to corneal mechanical stiffening that shows significant therapeutic benefits for patients with Keratoconus\, and also corneal flattening\, which could be helpful for the correction of minor refractive errors. However\, there are several drawbacks to UVA CXL including\, 1) difficulty controlling area and depth of corneal CXL\, and 2) removal of the corneal epithelium to imbibe riboflavin into the stroma. The former limits the ability of UVA CXL to customize corneal stiffening to treat refractive errors\, while the later leads to post-operative pain\, delayed visual recovery time\, and increased risk of infection. In this talk I will present our work on developing a non linear optical (NLO) approach to corneal CXL that addresses these major limitations. First\, we have developed a delivery device that focus amplified femtosecond laser pulses at any depth or position within the corneal stroma to precisely activate riboflavin using two photon excitation. Secondly\, we have used laser induced optical breakdown to machine the corneal epithelium and form microchannels that are 2-3 micron in diameter and 25 micron in length to significantly enhance to penetration of riboflavin through the corneal epithelium. We have also performed live rabbit eye studies showing that these advances protect the corneal epithelium from damage\, and can produce 1-2 diopters of central corneal flattening. \nBiography\nDr. Jester is currently the Jack H. Skirball Endowed Research Chair and Professor of Ophthalmology and Biomedical Engineering at the University of California\, Irvine. Dr. Jester’s trained as an Experimental Ocular Pathologist whose research has focused on the cellular and molecular biology of the cornea and ocular surface. Dr. Jester has extensive experience using multi-dimensional imaging modalities to evaluate corneal structure and function. His current research includes the application of non-linear optical microscopy to image second harmonic generated signals from collagen to study the collagen structural organization of the cornea. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova.\nSponsored by the Berns Family LAser and Microbeam Program and the Department of Ophthalmology URL:https://leadersinlight.com/event/james-v-jester/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/01/James-Jester.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20191022T120000 DTEND;TZID=UTC:20191022T130000 DTSTAMP:20260513T181604 CREATED:20191018T221509Z LAST-MODIFIED:20191018T221617Z UID:27380-1571745600-1571749200@leadersinlight.com SUMMARY:Professor Peter Török DESCRIPTION:Nanyang Technological University\, Singapore \nBrillouin Microscopy and Endoscopy \nAbstract\nBrillouin imaging can extract viscoelastic properties with micron-level resolution in a label-free\, non-invasive way. The conventional bulk-optics based Brillouin system has already been applied to various biological samples. While the utility of Brillouin imaging has been demonstrated\, the intrinsically weak scattering process means that recent work in instrumentation has aimed to maximize the efficiency of existing technology\, as well as making it more compact and portable. For more systematic optimization strategies\, the theoretical parameters to evaluate the performance of arbitrary Brillouin spectrometers have been proposed for the first time. This enables the optimization of Brillouin systems in general. In this talk I present the latest developments in Brillouin instrumentation. This also includes software-based reconstruction techniques to enhance the SNR of the system. These methods are more attractive for their wider applicability and have been found to be capable of extracting useful Brillouin shift value with low SNR in simulation and experiment.\nOne application of Brillouin imaging in particular – the in vivo assessment of arterial stiffness\, i.e. Brillouin Endoscopy\, is seen to have much potential as a diagnosis tool for cardiovascular diseases\, despite some challenges. We thus present recent effort on the optimization and miniaturization of the existing technology into a flexible\, fiber-based device has provided some solutions. The main consideration for creating a fiber-based Brillouin system is the strong background generated by the fiber. So far\, a proof-of-concept device that does not require filtering has been constructed and the measurements in typical liquids have been achieved. Alternatively\, a more efficient\, single-path set-up is also discussed as it may yield higher throughput.\nRecently\, the meaning of Brillouin measurements and its correlation to stiffness has been further investigated. It has been shown that the influence of water content in the mechanical behavior of hydrated samples may dominate the Brillouin shift value. The addition of a Raman mode to measure this relative change in hydration may help to yield more accurate mechanical measurements. The correlative study of hydrogels was thus demonstrated as to show that inelastic spectroscopy in tandem is viable.\nFinally\, to maximize the information from the hyperspectral data that is obtained from BI\, the power of some multivariate analysis algorithms is discussed as alternatives for future work\, the application in live cell imaging is highlighted. \nBiography \nPeter Török graduated with an MSc in Electrical Engineering (Microelectronics) from the Technical University of Budapest\, Hungary and a DPhil in Physical Sciences from the University of Oxford. After postdoctoral positions at the Universities of Cambridge and Oxford\, he was appointed Lecturer in Photonics at Imperial College London in 2002\, where he was promoted Reader in Photonics and Professor of Optical Physics in 2005 and 2009\, respectively. In 2018\, Peter moved to NTU where he has joint appointments with the Division of Physics and Applied Physics\, School of Physical and Mathematical Sciences\, Lee Kong Chian School of Medicine and the Singapore Centre for Environmental Life Sciences Engineering (SCLESE)\, where he is Director of Imaging. \nPeter has rich experience in designing and building precision optical system also including instruments that have been sold to word leading companies. He has spent most of his working life in optical and confocal microscopy\, polarized light imaging\, optical data storage\, electromagnetic imaging theory\, compressive/single pixel imaging\, reconfigurable optics and various metrology applications\, information theoretic aspects of imaging and spectroscopic imaging\, including Raman and Brillouin modalities. At NTU his group mostly concentrates on highly interdisciplinary applications of optics working in collaboration with colleagues in life- and biomedical sciences. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/peter-torok/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/10/Peter-Torok.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190812T120000 DTEND;TZID=UTC:20190812T130000 DTSTAMP:20260513T181604 CREATED:20190724T062243Z LAST-MODIFIED:20190724T062446Z UID:27290-1565611200-1565614800@leadersinlight.com SUMMARY:Thomas O’Sullivan\, PhD DESCRIPTION:Assistant Professor\, Department of Electrical Engineering\, University of Notre Dame \nFast-Changing Times: Advanced Optical Technologies Enabling the Next Generation of Quantitative Diffuse Optical Spectroscopy \nAbstract\nQuantitative Noninvasive Diffuse Optical Spectroscopy utilizing time-dependent methods can separate the effects of optical absorption and scattering and thus provide greater accuracy\, precision\, and 3D resolution of deep tissue physiology compared to continuous-wave methods. Unfortunately\, despite 30 years of research demonstrating its utility in a myriad of clinical applications (e.g. cancer\, neuroscience\, critical care\, metabolic disease\, etc.)\, time-dependent methods are complex\, bulky\, and expensive. This has resulted\, at best\, in slowed clinical adoption and\, at worst\, distrust of the technology itself. In order to overcome these barriers\, our group researches new optical components and techniques for diffuse optical spectroscopy that are leading to a new generation of handheld\, wearable\, and even implantable systems. This will facilitate the conversion of advanced time-dependent imaging methods to accessible compact systems that will drive widespread use in biomedical sensing and imaging. \nBiography\nDr. Thomas O’Sullivan has been an assistant professor in the Department of Electrical Engineering at the University of Notre Dame since 2016. Prior to that he was Director of the Diffuse Optical Spectroscopy and Imaging Laboratory at the Beckman Laser Institute of the University of California\, Irvine and a U.S. Department of Defense Breast Cancer Research Program Postdoctoral Fellow. He received the B.S. degree in Electrical Engineering from Northwestern University in 2005 and the M.S. and Ph.D. in Electrical Engineering from Stanford University in 2007 and 2011\, respectively. Dr. O’Sullivan is engaged in translational biomedical research based upon the development and application of deep tissue optical imaging and sensing. In addition to his research\, Dr. O’Sullivan is passionate about community outreach\, has served the optics and photonics community through multiple volunteer roles for OSA and SPIE\, and is currently an associate editor for Biomedical Optics Express. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/thomas-osullivan-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/07/Thomas-OSullivan-192.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190808T120000 DTEND;TZID=UTC:20190808T130000 DTSTAMP:20260513T181604 CREATED:20190711T015248Z LAST-MODIFIED:20190711T015324Z UID:27268-1565265600-1565269200@leadersinlight.com SUMMARY:Lida Hariri\, MD\, PhD DESCRIPTION:Assistant Professor\, Department of Pathology\nDivision of Pulmonary and Critical Care Medicine\nMassachusetts General Hospital\, Harvard Medical School \nIn Vivo Optical Coherence Tomography for Early Detection and Diagnosis of Pulmonary Disease \nAbstract\nIn vivo optical imaging provides microscopic images in patients\, in real time\, without tissue removal. Due to its high resolution\, optical imaging has close parallels with traditional microscopy and can complement and enhance patient care\, including in vivo disease detection\, biopsy guidance\, diagnosis\, and resection margin assessment\, in a variety of organ systems and disease types. In this talk\, I will discuss applications of optical coherence tomography for early detection and diagnosis of pulmonary diseases\, particularly lung cancer and interstitial lung disease\, and real-time tumor biopsy guidance to increase diagnostic yield. \nBiography\nLida Hariri\, MD\, PhD\, is an Assistant Professor of Pathology and biomedical optics researcher at Massachusetts General Hospital. She obtained her MD/PhD at the University of Arizona in 2009\, with her doctorate in Biomedical Engineering focused on multimodal optical imaging for early cancer detection. She subsequently completed her pathology residency training\, and pulmonary and gynecologic pathology fellowships at MGH. Her research interests focus on development\, translation and clinical application of high-resolution optical imaging for: 1) early detection and diagnosis of pulmonary diseases\, particularly lung cancer and interstitial lung disease\, 2) real-time tumor biopsy guidance to increase diagnostic yield\, and 3) integrating in vivo optical microscopy into the practice of clinical medicine and pathology. She is a Vice-Chair of the College of American Pathologists (CAP) In Vivo Microscopy Committee. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/lida-hariri-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/07/Hariri_Lida_192.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190722T120000 DTEND;TZID=UTC:20190722T130000 DTSTAMP:20260513T181604 CREATED:20190704T032500Z LAST-MODIFIED:20190704T033712Z UID:22042-1563796800-1563800400@leadersinlight.com SUMMARY:Liangzhong (Shawn) Xiang\, PhD DESCRIPTION:Assistant Professor of Electrical and Computer Engineering at University of Oklahoma \nStephenson Cancer Center at University of Oklahoma Health Sciences Center \nX-ray-induced Acoustic Computed Tomography (XACT) \nAbstract\nX-ray computed tomography (CT) has proved tremendously useful for noninvasive medical imaging ever since its inception nearly 50 years ago. However\, there remain two major limitations: radiation harm and inaccessibility to patient.\nIn 2013\, for the first time\, we reported a novel x-ray imaging modality\, x-ray induced acoustic computed tomography (XACT)\, to overcome these limitations of conventional x-ray CT imaging. In XACT\, pulsed x-ray excitation of a sample results in localized heating\, and subsequent thermoelastic expansion\, for sufficiently short-lasting pulses\, this results in the emission of a detectable acoustic wave in the ultrasound regime\, with amplitude proportional to x-ray absorption. This unique hybrid imaging modality combines high x-ray absorption contrast with the 3D propagation advantages provided by high resolution encoding ultrasound waves. XACT imaging shows potential to produce a 3D volumetric image from a single X-ray projection. Thus\, XACT can dramatically reduce radiation dose and improve imaging speed as compared to conventional x-ray CT with hundreds of projections. Moreover\, XACT imaging also requires only single-side access to the patient versus traditional X-ray imaging’s requirement for access to two opposing sides of the patient. We expect our work may profoundly advance X-ray imaging technology.\nMy main research interest is in developing XACT imaging and enable its clinical translation. I will present a wide range of applications of XACT ranging from radiation oncology (in vivo dosimetry for external radiotherapy on breast cancer and prostate cancer)\, to radiological imaging (breast microcalcification\, bone tumor\, and osteoporosis). \nBiography\nDr. Liangzhong Xiang is an Assistant Professor in the Department of of Electric and Computer Engineering\, and Stephenson Cancer Center at University of Oklahoma (OU). Dr. Xiang received his Ph.D. degree from South China Normal University on photoacoustic molecular imaging. He was a postdoctoral fellow trained in medical physics at Stanford Medical School\, and he awarded the U.S. Department of Defense (DoD) Prostate Cancer Postdoctoral Training Program at Stanford University (2012-2015).\nIn research\, Dr. Xiang and his laboratory was the first to report x-ray-induced acoustic computed tomography (XACT). His work on XACT imaging was the cover article for Medical Physics in 2013. His talk entitled “X-ray acoustic computed tomography: concept and design” has been identified as a “Hot Topic” presentation for the 2013 AAPM Annual Meeting. And he received the Slvia Sorkin Greenfield Award for the best paper of the Medical Physics at AAPM 50th Annual Meeting. His research has led to over 60+ peer-reviewed publications\, 12 patents\, 30+ presentations. Sponsored by NIH\, DoD and Oklahoma state funding agencies with over $ 3 million dollars active grant support. In education\, he received Nancy L. Mergler Faculty Mentor Award for Undergraduate Research (the only recipient at OU in 2017). He strategically guides lab students to become extraordinary and independent scientists. His students have been awarded SPIE Education Scholarship (2019\, 2018)\, SPIE Travel Scholarship (2016). His postdoctoral research fellows were awarded the Trainee Research Prize from the Radiological Society of North America (RSNA\, 2015). In service\, Dr. Xiang has served as conference chairs in AAPM annual meeting (2019) and International Conference on Information Optics and Photonics (CIOP 2018)\, SPIE Student Chapter advisor\, associate editor of Medical Physics journal\, and grant reviewer for U S Department of Energy\, Russian Science Foundation (RSF)\, and Helmholtz Association of German Research Centre. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/liangzhong-xiang-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/07/Liangzhong-Xiang.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190718T120000 DTEND;TZID=UTC:20190718T130000 DTSTAMP:20260513T181604 CREATED:20190704T033854Z LAST-MODIFIED:20190704T034318Z UID:22051-1563451200-1563454800@leadersinlight.com SUMMARY:Bahman Anvari\, PhD DESCRIPTION:Professor\, Department of Bioengineering\, UC Riverside \nCancer Photo-Theranostics \nAbstract\nNano-sized structures provide a platform for the delivery of imaging and therapeutic agents to tumors. When activated by light\, these structures enable visualization of small tumor nodules and their destruction through a variety of photo-transduction mechanisms. My lab focuses on the engineering of nano-sized platforms derived from biological materials\, including erythrocytes\, and their translation for cancer photo-theranostics. In this talk\, I will present some of the photophysical properties of these constructs when doped with near infrared chromophores\, and show their capabilities in targeted fluorescence molecular imaging of important cancer cell biomarkers and photo-destructions of tumor implants in animal models. I will also discuss some of the considerations necessary for clinical translation of these structures in a safe manner. \nBiography\nBahman Anvari is a Professor in the Department of Bioengineering at UC Riverside\, and holds courtesy appointments in the Departments of Biochemistry\, and Mechanical Engineering\, and Biophysics and Biomedical Sciences Graduate Programs at UCR. He received his B.A. in Biophysics from UC Berkeley\, and Ph.D. in Bioengineering from Texas A&M University. He was a Postdoctoral Researcher at the Beckman Laser Institute\, and started his faculty career as an Assistant Professor in the Department of Bioengineering at Rice University where he became an Associate Professor.\nDr. Anvari’s scientific interests include the development and application of optical probes for biomedical imaging and therapeutic purposes. He is a co-inventor on some of the patented technologies related to the dynamic cooling of human skin. His research activities have been continuously funded by NIH\, NSF\, and other agencies. He has published over 300 peer-reviewed and conference papers. Dr. Anvari served as an Associate Editor for the Annals of Biomedical Engineering for nearly ten years\, and is currently an Editorial Board Member of Journal of Biomedical Optics. Professor Anvari is a Fellow of American Institute for Medical and Biological Engineering (AIMBE)\, American Association for the Advancement of Science (AAAS)\, Biomedical Engineering Society (BMES)\, and the International Society for Optics and Photonics (SPIE). He is the 2019 recipient of the Caroline & William Mark Memorial Award by the American Society for Laser Medicine & Surgery (ASLMS)\, and currently serves as the Basic Science Representative at ASLMS Board. Dr. Anvari is the founder of Radoptics\, LLC\, a start-up company interested in commercialization and translation of cell-derived optical probes. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/bahman-anvari-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/07/Anvari.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190710T120000 DTEND;TZID=UTC:20190710T130000 DTSTAMP:20260513T181604 CREATED:20190612T010718Z LAST-MODIFIED:20190704T032053Z UID:21570-1562760000-1562763600@leadersinlight.com SUMMARY:Ghazal Azarfar\, Ph.D. DESCRIPTION:Research Assistant at the Laboratory for Surface studies\, University of Wisconsin\, Milwaukee \nLight Scattering in Diffraction Limit Infrared Hyperspectral Imaging\nAbstract\nFourier Transform Infrared (FTIR) microspectroscopy is a noninvasive technique for chemical imaging of micrometer size samples. Employing an infrared source\, a microscope coupled to a FTIR spectrometer\, and replacing a single detector with an array of detectors (128 x 128 detectors) enables collecting combined spectral and spatial information simultaneously\, resulting in wavelength dependent images which\, are being used for disease pathology and cell cycle study. In this research we are trying to remove one of the last technological barriers to the development of clinical spectroscopic cytology.\nIn diffraction limit FTIR imaging\, where the size of the sample is in the same range as the incident light\, scattering phenomenon appear in spectra as a result of the interaction of the light and matter. The observed scattering contribution dependents physical and chemical structure of the sample as well as the focusing optic and the light source. A new optimization method for correcting the scattering phenomena in pixelated infrared spectra and recovering wavelength dependent complex refractive of the sample using holographic phase images will be presented. \nBiography \nDr. Ghazal Azarfar has defended her PhD thesis in Electrical Engineering in June 2019.  She is currently working as a research assistant at the Laboratory for Surface Studies at University of Wisconsin Milwaukee (UWM). She is the president of the society for applied spectroscopy at UWM\, and has received multiple awards including the Four-Year Dean’s fellowship award\, Chancellor’s award  and Honorable Mention award. She has published a paper on Fourier transform infrared imaging of a single live cell. The focus of her research is scattering correction in the diffraction limit hyperspectral infrared imaging. Her research resulted in a new algorithm for 3D reconstruction of holographic images. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Zhongping Chen URL:https://leadersinlight.com/event/ghazal-azarfar/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/06/Ghazal-Azarfar.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190709T120000 DTEND;TZID=UTC:20190709T130000 DTSTAMP:20260513T181604 CREATED:20190627T043107Z LAST-MODIFIED:20190629T032737Z UID:21882-1562673600-1562677200@leadersinlight.com SUMMARY:Toyohiko Yamauchi DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nQuantitative Phase Microscopy for the Evaluation of Cell Morphological Properties\nAbstract\nCell morphology and dynamics are related to a variety of significant biomedical properties\, such as the metastatic potential of cancer cells\, disease related stiffness changes in red blood cells\, pluripotency of stem cells\, and cell-to-cell interactions by tunneling nanotubules. Phase contrast microscopes or differential interference contrast microscopes are the most popular methods to evaluate the morphological features of live cells\, but these methods are not quantitative nor reproducible between different models of microscopes. For these reasons\, there has been a push to develop and validate more quantitative microscopy techniques\, such as Quantitative Phase Microscopy (QPM). QPM is an interferometry-based technique which measures the optical thickness of cells. Optical thickness is a well-defined physical property and can be used to obtain quantitative and reproducible thickness mapping of live cells within a clear background. By means of the image processing on optical thickness\, QPM enables the tracing of cell boundaries and the quantification of vectors of membrane motion. Moreover\, QPM does not require fluorescence dye (label free) and it enables long term\, time-lapse imaging of live cells for more than 48 hours. In this talk\, Toyohiko Yamauchi will introduce the theory of QPM and detail his efforts in designing\, building\, and testing QPM instruments.\nToyohiko installed his latest QPM prototype in the Beckman Laser Institute in February 2018 and has been building new research collaborations throughout UCI to develop new applications. In the latter half of this seminar\, several active collaborators will also talk about ongoing and future studies with QPM. \nBiography\nToyohiko Yamauchi graduated from the University of Tokyo with undergraduate and master’s degrees in electrical engineering. Toyohiko has been an application researcher of optical interferometry for Hamamatsu Photonics (Japan) for more than 10 years. From 2008 to 2010\, Toyohiko worked as a visiting scientist with Dr. Michael S. Feld at the MIT-Laser Biomedical Research Center to develop his quantitative phase microscope. After returning to Japan\, Toyohiko joined a government sponsored New Energy and Industrial Technology Development Organization (NEDO) project for low-invasive quality assessment of induced pluripotent stem cells from 2011 to 2014. Since then\, Toyohiko has been collaborating with biologists in both the US and in Japan for application development of QPM and he most recently spent 18 months at UCI as a visiting researcher. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/toyohiko-yamauchi/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2018/12/ToyohikoYamaychi.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190708T120000 DTEND;TZID=UTC:20190708T130000 DTSTAMP:20260513T181604 CREATED:20190618T055844Z LAST-MODIFIED:20190618T060334Z UID:21585-1562587200-1562590800@leadersinlight.com SUMMARY:Mihaela Balu\, Ph.D. DESCRIPTION:Associate Researcher at the Beckman Laser Institute\, UC Irvine \nClinical skin imaging with multiphoton microscopy– current strategies and future directions \nAbstract\nThe ability of multiphoton microscopy (MPM) to generate high-resolution 3D maps of specific tissue molecular compounds led to its widespread use in biomedical applications. MPM has been successfully employed in research labs for basic biology studies and imaging of small animal models but due to the complexity and cost of the microscope systems\, only recently it started to be explored as a technique for non-invasive in-vivo human skin imaging. In the US\, the first clinical skin imaging research studies using MPM have been initiated at BLI by our group in collaboration with the Dermatology Department at UCI using the first commercial clinical MPM system. Since 2012\, ~300 patients have been enrolled in our research studies. In this talk\, I will present results from several MPM clinical studies\, with an emphasis on our most advanced research on quantitative imaging for non-invasive early diagnosis of melanoma. Other applications include employing in vivo MPM for guiding treatment of pigmentary skin disorders and monitoring the re-pigmentation process of skin disorders such as vitiligo. These applications have been driven by novel MPM developments. In the same time\, they are driving further advances of the technology to address current barriers\, such as limited scanning area and scanning speed. I will present an overview of the current stage of development of our proposed clinical MPM platform for skin imaging that addresses these limitations\, while offering enhanced portability and reduced complexity. I will also discuss the challenges involved in the translational process of this technology and potential approaches to overcome them\, along with strategies for integrating advanced imaging with artificial intelligence-based diagnostic algorithms and with single cell transcriptomics to capture the cellular\, molecular and metabolic signatures in tissues of interest. \nBiography\nMihaela Balu\, Ph.D.\, is Associate Researcher at the Beckman Laser Institute\, UC Irvine. She has a Master in Physics and a PhD in Optics from the College of Optics and Photonics (CREOL)\, University of Central Florida. Her research is focused on integrating and advancing modern biophotonics technologies such as nonlinear optical microscopy to clinical setting. Her main goal is to use this technique as a non-invasive imaging tool for visualizing\, quantifying and understanding the morphological and underlying molecular processes in skin\, with a particular interest in melanoma and non-melanoma skin cancer. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/mihaela-balu-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/06/Mihaela-Balu.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190702T120000 DTEND;TZID=UTC:20190702T130000 DTSTAMP:20260513T181604 CREATED:20190613T053318Z LAST-MODIFIED:20190613T053318Z UID:21581-1562068800-1562072400@leadersinlight.com SUMMARY:Stefan Carp\, PhD DESCRIPTION:Assistant Professor of Radiology at Harvard Medical School \nNon-invasive Biophotonics for Personalized Medicine\nAbstract\nPersonalized or precision medicine is an emerging paradigm in health care delivery that seeks to tailor medical treatment to the individual characteristics\, needs and preferences of each patient. Biophotonic technologies are likely to play a significant role in realizing the benefits of personalized medicine by leveraging novel contrast mechanisms to offer timely feedback on treatment progress\, and can be integrated into compact\, cost-effective devices that are suitable for longitudinal patient monitoring.\nOur work has been focused on the technology development and clinical translation of optical imaging and sensing using near-infrared light. This talk will report on our efforts in two major application areas: in the context of breast cancer management\, we are combining dynamic diffuse optical tomography with x-ray digital breast tomosynthesis to improve breast cancer diagnosis and neoadjuvant chemotherapy monitoring outcomes; in the context of neuromonitoring\, we are advancing methods for the accurate quantification of brain health in the presence of systemic physiology interference in adults\, by using a combination of near-infrared spectroscopy and diffuse correlation spectroscopy techniques together with advanced light transport models\, with the goal to offer new tools for improving the management of brain perfusion in patients undergoing cardiovascular interventions. \nBiography\nDr. Stefan Carp is an Assistant Professor of Radiology at Harvard Medical School and a member of Massachusetts General Hospital Martinos Center Optics Division. He received his BS degrees in chemistry and chemical engineering from MIT and pursued his doctorate at U.C. Irvine (UCI) under the supervision of Dr. Vasan Venugopalan. At UCI he discovered the field of biomedical optics and developed a non-contact optoacoustic imaging system for his dissertation project. After graduation\, he worked on optical breast imaging after moving to the Massachusetts General Hospital\, where he now leads a research group that focuses on the development of novel techniques for tissue hemodynamics and oxygen metabolism monitoring to help advance personalized medicine. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/stefan-carp-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/06/CARP.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190701T120000 DTEND;TZID=UTC:20190701T130000 DTSTAMP:20260513T181604 CREATED:20190613T052528Z LAST-MODIFIED:20190613T052528Z UID:21577-1561982400-1561986000@leadersinlight.com SUMMARY:Nicholas J. Durr\, Ph.D. DESCRIPTION:Assistant Professor of Biomedical Engineering\, Johns Hopkins University \nDesigning Solutions to Healthcare Needs With Computational Biophotonics\nAbstract\nComputational biophotonics pairs optical system design with the development of intelligent algorithms to extract meaningful data from interrogated tissues (often via an unintuitive computational image). With the recent dramatic advances in deep learning tools\, there are many exciting opportunities to apply data-driven models with novel imaging systems to create impactful medical devices. I will present our efforts in developing and translating computational biophotonics medical devices for a variety of important healthcare needs\, including: (1) improving the management of colorectal cancer with deep learning and the computational colonoscope\, (2) enabling a non-invasive blood count with gradient-field capillaroscopy\, and (3) making eye care more accessible with a low-cost\, handheld wavefront aberrometer. \nBiography\nNicholas Durr is an Assistant Professor of Biomedical Engineering at Johns Hopkins University and the co-Director of Undergraduate Programs at the Center for Bioengineering Innovation and Design (CBID). He received a B.S. in Electrical Engineering and Computer Science from U.C. Berkeley in 2003\, worked as a Research Engineer at Nellcor from 2003 to 2004\, and received a Ph.D. in Biomedical Engineering from U.T. Austin in 2010. He completed a Postdoctoral Fellowship at Harvard Medical School in 2011 and was an independent investigator at MIT from 2011 to 2014 as a Fellow in the M+Visión Consortium. In 2013 he co-founded PlenOptika\, which he led as CEO until he joined Hopkins in 2016. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/nicholas-durr-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/06/NDURR.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190613T120000 DTEND;TZID=UTC:20190613T130000 DTSTAMP:20260513T181604 CREATED:20190603T230251Z LAST-MODIFIED:20190603T231717Z UID:21541-1560427200-1560430800@leadersinlight.com SUMMARY:Anand Kumar\, PhD DESCRIPTION:Assistant Professor\, Harvard Medical School\nAssistant Professor\, Massachusetts General Hospital\, Boston \nBiological imaging with time domain fluorescence\nAbstract\nMolecular imaging combines the use of disease targeted contrast agents with advanced imaging techniques to visualize disease processes in whole living organisms from the small animal to the human scale. Optical techniques are emerging as promising tools for molecular imaging by providing functional contrast\, and are particularly attractive given the spectral and fluorescence lifetime tunability of near infrared fluorophores. This allows the exciting possibility of multiplexing using fluorescence spectral and lifetime contrast. \nMy laboratory is focused on the development and application of whole-body time domain imaging techniques\, with emphasis on exploiting lifetime contrast for enhanced sensitivity and specificity of disease detection in vivo. Although fluorescence lifetime imaging has been widely used in microscopy using fluorescence lifetime imaging (FLIM)\, the application of lifetime imaging for macroscopic subjects has been limited by several challenges. This presentation will outline some of these challenges and how they can be addressed using theoretical and experimental methods for time domain imaging. In particular\, I will discuss a novel algorithm for tomographic lifetime multiplexing which allows the complete separation and 3-D localization of multiple lifetimes simultaneously present within biological tissue. Recent extensions of this work to the spatial frequency domain using modulated sources will also be discussed. I will then present in vivo applications of the technology pertaining to cancer and cardiac disease models. I will finally discuss our recent progress towards clinical applications of fluorescence lifetime imaging for cancer detection. \nBiography\nAnand Kumar is an Assistant Professor at Harvard Medical School and the Massachusetts General Hospital in Boston. Dr. Kumar received his M.Sc. from the Indian Institute of Technology\, Chennai\, India and Ph. D. from Northeastern University\, Boston\, both in Physics. Following his doctoral work on ultrafast laser spectroscopy\, he worked in Sycamore Networks as a Senior Optical Engineer for 2 years\, where he designed commercial fiber optic networks. Subsequently\, he moved to the Athinoula A. Martinos center in 2002 as a post-doctoral fellow and joined the faculty of the center as an Instructor in 2007 and Assistant Professor in 2012. His current research focus is on preclinical and clinical applications of diffuse optical tomography and optical molecular imaging\, with particular emphasis on time domain imaging techniques. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim. URL:https://leadersinlight.com/event/anand-kumar-phd/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/06/ANAND-KUMAR-192.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190610T120000 DTEND;TZID=UTC:20190610T130000 DTSTAMP:20260513T181604 CREATED:20190530T230819Z LAST-MODIFIED:20190604T034800Z UID:21528-1560168000-1560171600@leadersinlight.com SUMMARY:Anita Mahadevan-Jansen\, PhD DESCRIPTION:Professor of Biomedical Engineering at Vanderbilt University \nProblem-based research shortens the pathway to to clinical translation of light-based technologies\nAbstract\nMedicine is a problem rich environment where there is a critical need for new solutions that ease the life of the patient\, the physician and the caregiving staff. For at least some of these problems\, biophotonics could well be the answer! Optical techniques can be used to provide real-time assessment for screening\, diagnosis\, monitoring and guidance of therapy. In this presentation – I will discuss 2-3 different medical challenges and the optical solution that was developed and implemented in a clinical setting. These examples include the application of near infrared fluorescence imaging for the anatomical detection of the parathyroid gland during endocrine surgery and in vivo biochemical characterization of the pregnant human cervix towards understanding preterm birth. \nBiography\nDr. Mahadevan-Jansen translates optical techniques for clinical detection of tissue physiology and pathology. Her primary research at the Vanderbilt Biophotonics Center\, is to investigate the applications of optical spectroscopies and imaging for disease diagnosis and guidance of therapy. She received her bachelor’s and master’s degrees in Physics from the University of Bombay (Mumbai)\, India\, and a master’s and PhD degrees in Biomedical Engineering from the University of Texas at Austin. She joined the Vanderbilt engineering faculty in 1996. She is currently the Orrin H. Ingram Professor of Biomedical Engineering at Vanderbilt University and holds a secondary appointment in the Departments of Neurological Surgery and Otolaryngology. She is the founding Director of the Vanderbilt Biophotonics Center\, the Director of the Vanderbilt branch of the Center for Integration of Research in Teaching and Learning (CIRTL)\, an NSF funded 46-institution center as well as Director of Undergraduate Studies for the Department of Biomedical Engineering at Vanderbilt University.\nShe is currently on the Board of Directors of the International Society for Optical Engineering (SPIE) and is a fellow of SPIE\, Optical Society of America (OSA) as well as the American Institute of Medical and Biological Engineering (AIMBE). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/anita-mahadevan-jansen-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/anita.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190606T123000 DTEND;TZID=UTC:20190606T133000 DTSTAMP:20260513T181604 CREATED:20190521T230028Z LAST-MODIFIED:20190524T004017Z UID:21481-1559824200-1559827800@leadersinlight.com SUMMARY:Joseph A. Izatt\, PhD DESCRIPTION:Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\nProfessor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University \nNew Optical Technologies for Real-Time Biomedical Imaging and Image-Guided Surgery\nAbstract\nCutting edge optical biomedical imaging technologies adaptively control optical wavefronts and exploit spatial and temporal coherence to obtain wavelength-scale measurements of structure and function inside living biological tissues\, while leveraging optical communications bandwidths to enable real-time 3D imaging. We have developed implementations of these technologies for multiple applications including super-resolved non-invasive retinal imaging\, flexible hand-held interactive clinical diagnostic imaging\, and real-time intrasurgical visualization and operative guidance. These advances allow for continuous volumetric microstructural imaging in living patients\, and extend the benefits of the latest imaging technologies to previously inaccessible patient populations. Using these tools\, we have demonstrated live imaging of individual retinal receptor cells both with and without adaptive optics\, including the first demonstrations of retinal cone cell imaging in infants and children. We have pioneered the integration of optical coherence tomography into ophthalmic microsurgery\, including surgical microscope-integrated image acquisition\, real-time augmented reality visualization\, and image-guided tele-operative and cooperative robotic manipulation of surgical tools with micrometer-scale precision. Several of these technologies have accomplished the transition from basic research\, to clinical trials\, to wide-scale adoption and commercial success\, and thus serve as useful examples of the accumulating impact and continuing importance of innovation in biomedical optics and biophotonics. \nBiography\nJoseph A. Izatt is the Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering\, Professor of Ophthalmology\, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University. Prof. Izatt’s research interests include biomedical optics and spectroscopy\, coherence-based and wavefront-optimized tomographic optical imaging\, and novel instrumentation for intrasurgical visualization and manipulation. He has authored over 200 peer-reviewed publications\, more than 350 contributed and 130 invited lectures and presentations\, and more than 70 issued patents\, which altogether have accumulated over 38\,000 citations. Izatt was the founding Editor-In-Chief of Biomedical Optics Express\, OSA’s principle outlet serving the biomedical optics community\, and has co-chaired the leading annual conference in Optical Coherence Tomography (at SPIE’s Photonics West) for two decades. Professor Izatt has worked with multiple companies to license commercial technologies related to optical biomedical imaging\, including co-founding Bioptigen\, Inc.\, which was acquired by Leica Microsystems in 2015. Dr. Izatt is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, The International Society for Optics and Photonics (SPIE)\, The Optical Society (OSA)\, and the National Academy of Inventors (NAI). \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/joseph-a-izatt-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/Izatt.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190603T120000 DTEND;TZID=UTC:20190603T130000 DTSTAMP:20260513T181604 CREATED:20190530T222905Z LAST-MODIFIED:20190603T232041Z UID:21513-1559563200-1559566800@leadersinlight.com SUMMARY:Xueding Wang\, Ph.D. DESCRIPTION:Department of Biomedical Engineering\nDepartment of Radiology\nUniversity of Michigan School of Medicine \nLight plus Sound: Photoacoustic Imaging and Treatment\nAbstract\nPhotoacoustic imaging (PAI)\, also referred to as optoacoustic imaging\, is an emerging biomedical imaging technology that is noninvasive\, nonionizing\, with high sensitivity\, satisfactory imaging depth and good temporal and spatial resolution. Like conventional optical imaging\, PAI presents the optical contrast which is highly sensitive to molecular conformation and biochemical contents of tissues and can aid in describing tissue metabolic and hemodynamic changes. Unlike conventional optical imaging\, the spatial resolution of PAI is not limited by the strong light diffusion but instead determined by the measurement of light-generated ultrasonic signals. As a result\, the resolution of PAI is parallel to high-frequency ultrasonography. \nAt the University of Michigan School of Medicine\, our research has been focused on clinical applications of PAI\, including arthritis\, cancer\, liver conditions\, Crohn’s disease\, and eye diseases.  In this talk\, I will introduce some of our recently development of PAI technologies\, including 1) development of point-of-care PAI system for human inflammatory arthritis\, and 2) development of quantitative PAI for evaluating histological microfeatures and microenvironment of cancer. I will also present our recent development of a photoacoustic based anti-vascular technology named photo-mediated ultrasound therapy (PUT). Using a combination of a low intensity laser concurrently with ultrasound\, PUT can noninvasively remove microvessels without damaging surrounding biological tissue\, and shows potential to the treatment of a variety of diseases associated with neoangiogenesis\, such as age-related macular degeneration and diabetic retinopathy\, as well as port-wine stain and cancer. \nBiography\nDr. Xueding Wang is a Professor at the Department of Biomedical Engineering\, University of Michigan\, holding an adjunct Professor position at the Department of Radiology. Before working as an independent principle investigator\, Dr. Wang received his Ph.D. from Dr. Lihong Wang’s lab at the Dwight Look College of Engineering at Texas A&M University\, and then finished postdoctoral training at the University of Michigan School of Medicine under the guidance of Prof. Paul Carson. Dr. Wang has extensive experience in optical and ultrasound imaging and treatment system development and adaptation of novel diagnostic and therapeutic modalities to preclinical and clinical settings. Sponsored by NIH\, NSF\, DoD and other funding agencies\, his research has led to over 110+ peer-reviewed publications. At the University of Michigan Medical School\, a major part of his research is focused on clinical applications of photoacoustic imaging and therapy\, including those involving arthritis\, prostate cancer\, liver conditions\, breast cancer\, Crohn’s disease\, and eye conditions. Dr. Wang is the recipient of the Sontag Foundation Fellow of the Arthritis National Research Foundation in 2005\, and the Distinguished Investigator Award of the Academy of Radiology Research in 2013. He is also sitting on the editorial boards of scientific journals including Photoacoustics\, Journal of Biomedical Optics\, Medical Physics\, and Ultrasonic Imaging\, and being the steering committee member of the Journal of Lightwave Technology. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Bernard Choi URL:https://leadersinlight.com/event/xueding-wang-ph-d-2/ LOCATION:3201 Natural Sciences II ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/02/Wang-2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190530T120000 DTEND;TZID=UTC:20190530T130000 DTSTAMP:20260513T181604 CREATED:20190521T224854Z LAST-MODIFIED:20190524T003346Z UID:21472-1559217600-1559221200@leadersinlight.com SUMMARY:Kishan Dholakia\, PhD DESCRIPTION:Professor at the University of St Andrews\, Scotland\nHonorary Adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India \nShaped Light for the Future of Biomedical Imaging\nAbstract\nI will review recent progress in various aspects of biomedical imaging at St Andrews in my group that has used innovation in shaping light in both space and time. I will cover the topics of wavelength modulated Raman analysis and digital holographic microscopy which we have used to develop label-free hemograms and studies for detection of phenotypically resistant mycobacterium tuberculosis. The main part of my talk will cover the topic of light sheet imaging with propagation invariant light beams (Airy\, Bessel) that offer excellent prospects for new studies in neuroscience\, developmental biology and histopathology. I will conclude with a novel form of imaging where we use temporal focusing with single pixel detection for wide field multiphoton imaging at depth without the need to characterize the scattering media. The potential impact of these imaging modalities for disease detection and clinical implementation will be emphasized. \nBiography\nKishan Dholakia is Professor at the University of St Andrews\, Scotland and an honorary adjunct Professor at the Centre for Optical Sciences at the University of Arizona\, USA\, at Chiba University\, Japan and IIT\, Madras\, India. He works on advanced imaging for neuroscience and cancer diagnosis\, beam shaping and optical manipulation leading a group of around 20 researchers. He has published over 300 journal papers\, has in excess of 26\,000 citations. His work is cited in the Guinness Book of Records 2015. He is a Fellow of the Royal Society of Edinburgh\, OSA and SPIE. In 2016 he won the R.W. Wood Prize of the Optical Society\, in 2017 he won the IOP Thomas Young Medal and Prize and in 2018 was the recipient of the SPIE Dennis Gabor Award. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/kishan-dholakia-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/dholakia.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190528T120000 DTEND;TZID=UTC:20190528T130000 DTSTAMP:20260513T181604 CREATED:20190521T222208Z LAST-MODIFIED:20190521T223519Z UID:21462-1559044800-1559048400@leadersinlight.com SUMMARY:Elizabeth Hillman\, PhD DESCRIPTION:Professor of Biomedical Engineering and Radiology\nZuckerman Mind Brain Behavior Institute at Columbia University \nUsing Light to Image at the Speed of Life\nAbstract\nLight is uniquely capable of probing and changing the electron and vibrational energy levels of molecules. As a result\, light can be used to spectrally discern a tissue’s chemical composition\, excite activity in a neuron and change the shape of the cornea in laser eye surgery. As lasers\, light-sources\, detectors and cameras continue to improve\, the opportunities to leverage the power of light for biomedical discovery\, diagnosis and treatment are continually expanding.\nAn area of enormous growth in the past decade has been the development of fluorescent protein-based reporters of cellular activity and optogenetics\, which combined have unlocked our ability to observe and manipulate cell signaling across scales. The result is a rich and expanding toolkit for studying how intact\, living organs\, organoids and organisms function\, and how they are affected by disease\, which in turn is fueling revolutions in neuroscience\, drug discovery\, personalized medicine. However\, a major bottleneck for these techniques is imaging speed. We developed swept confocally aligned planar excitation (SCAPE) microscopy to address this need for speed\, enabling 3D imaging in living tissues at over 100 volumes per second. SCAPE combines the high signal to noise and low photobleaching benefits of light sheet imaging with confocal descanning principles that enable high-speed scanning through a simple single\, stationary objective lens. Through diverse collaborations\, we have demonstrated SCAPE’s ability to image cellular activity in a wide range of living organisms including freely crawling Drosophila larvae\, the whole brain of behaving adult Drosophila\, zebrafish brain and heart\, 3D culture systems and the awake mouse cortex. We are now developing a range of new SCAPE systems including two-photon\, higher resolution and meso-scale versions\, as well as platforms for high-throughput and high-content imaging of cleared and expanded tissues\, and a miniaturized version of SCAPE for in-situ histopathology for clinical surgical guidance.\nSCAPE is one example of our innovations that have continually sought to leverage the power of light to capture in-vivo dynamics. In parallel we have developed image analysis methods for spatiotemporal and hyperspectral unmixing enabling us to relate complex multidimensional observations to physiological phenomena and behavior. We are applying these tools in our own studies of real-time brain-wide neural activity\, and to explore the relationship between blood flow and neural activity in the brain\, seeking biomarkers and therapeutic targets for neurovascular dysfunction. \nBiography\nDr Elizabeth Hillman is a Professor of Biomedical Engineering and Radiology\, and a member of the Zuckerman Mind Brain Behavior Institute at Columbia University. Dr Hillman completed her undergraduate degree in Physics\, and PhD in Medical Physics and Bioengineering at University College London. After a year at a Boston medical device start-up company\, Dr Hillman completed postdoctoral training at the Martinos center for Biomedical Imaging at Massachusetts General Hospital / Harvard Medical School before becoming faculty at Columbia University in 2006. Prof Hillman has developed a range of novel approaches to in-vivo optical imaging and microscopy for both clinical and research applications. Her PhD work focused on time-resolved diffuse optical tomography of the breast and premature infant brain\, while her innovations since have included Dynamic Contrast enhanced molecular imaging (DyCE\, licensed to CRi Inc\, now PerkinElmer)\, Laminar Optical Tomography for brain and skin imaging\, hyperspectral two-photon microscopy\, wide-field optical mapping (WFOM) of neuronal activity and hemodynamics and most recently high-speed 3D swept confocally aligned planar excitation (SCAPE) microscopy (now licensed to Leica Microsystems). Continuing technology development includes new variants of SCAPE including a miniaturized clinical version for ‘real-time’ intrasurgical in-situ histopathology. Dr Hillman also has an active research program applying her in-vivo imaging tools to studying neurovascular coupling and brain-wide resting state neural activity dynamics in the healthy\, diseased and developing rodent brain. Dr Hillman has developed educational programs at Columbia University focusing on Disruptive Biomedical Design\, Biomedical Imaging and Advanced Microscopy. She is a Fellow of the OSA\, SPIE and AIMBE\, and her awards include an NSF CAREER Award in 2010\, the 2011 Optical Society of America Lomb Medal for contributions to optics at a young age\, and the SPIE Biophotonics Technology Innovator award in 2018. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/elizabeth-hillman-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/hillman_UCI.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190516T120000 DTEND;TZID=UTC:20190516T130000 DTSTAMP:20260513T181604 CREATED:20190201T024715Z LAST-MODIFIED:20190516T224250Z UID:7506-1558008000-1558011600@leadersinlight.com SUMMARY:Alon Gorodetsky\, PhD DESCRIPTION:UC Irvine Assoc. Professor\nDepartment of Chemical Engineering and Material Sciences \nDynamic Materials Inspired By Cephalopods\nAbstract\nCephalopods (squid\, octopuses\, and cuttlefish) have captivated the imagination of both the general public and scientists alike for more than a century due to their visually stunning camouflage displays\, sophisticated nervous systems\, and complex behavioral patterns. Given their unique capabilities and characteristics\, it is not surprising that these marine invertebrates have emerged as exciting models for novel materials and systems. Within this context\, our laboratory has developed various cephalopod-derived and cephalopod-inspired materials with unique functionalities. Our findings hold implications for next-generation adaptive camouflage devices\, sensitive bioelectronic platforms\, and advanced renewable energy technologies. \nBiography\nDr. Alon Gorodetsky is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the University of California\, Irvine\, with joint appointments in the Department of Chemistry and the Department of Materials Science and Engineering. Dr. Gorodetsky obtained B.S. degrees in Engineering Physics and Materials Science at Cornell University and a Ph.D. in Chemistry at the California Institute of Technology. He subsequently completed postdoctoral work as a National Science Foundation American Competitiveness in Chemistry Fellow at Columbia University. His current research is focused on the development of macromolecular and biomolecular materials inspired by natural systems\, with an emphasis on cephalopods. His work has been featured in Popular Science\, Popular Mechanics\, Newsweek\, The Telegraph\, Wired\, The Verge\, Fox News\, NPR Marketplace\, BBC World\, CNN and other popular media. For his studies\, Dr. Gorodetsky has received several awards\, including the Henry Samueli School of Engineering Mid-Career Faculty Excellence in Research Award\, Applied Innovation Early Career Innovator of the Year Award\, the AFOSR Young Investigator Award\, the DARPA Young Faculty Award with the Director’s Option\, and the Presidential Early Career Award for Scientists and Engineers. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/alon-gorodetsky-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2019/01/alon-gorodetsky.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190513T121500 DTEND;TZID=UTC:20190513T131500 DTSTAMP:20260513T181604 CREATED:20190503T001639Z LAST-MODIFIED:20190503T010125Z UID:21411-1557749700-1557753300@leadersinlight.com SUMMARY:Brian W. Pogue\, Ph.D. DESCRIPTION:MacLean Professor of Engineering\, Dartmouth\nEditor-in-Chief\, Journal of Biomedical Optics\, SPIE Press \nImaging Medicine\nAbstract\nWhile the field of Medical Imaging is dominated by radiological devices\, the field of Imaging Medicine today is dominated by optical devices.   Optical imaging is commonly used at the point-of-care\, where patient and physician are in the same room together.  These procedure-based tools are used to capture unique contrast features that help guide medical decisions. In the Optics in Medicine cluster at Dartmouth scientific discovery and technology development are advanced side-by-side in areas such as image-guided spectroscopy of cancer\, surgical guidance tools with molecular specificity\, smart photodynamic therapy\, and novel radiologic guidance and dosimetry tools for remote non-contact monitoring of Cherenkov and scintillation light.  Examples from each will be used to highlight innovations in translational research that have gone from scientific concept through to technology development and into clinical trials.  Translating optical Imaging systems beyond the pilot trial phase involves the type of R&D which only companies can accomplish\, and so examples of strategic partnerships with companies in translational research will be shown.  Venture creation through a startup company\, DoseOptics LLC\, will be highlighted in which this pathway has enabled testing and deployment of a fundamentally new technology to image radiation dose delivery in real time for the first time in history\, and extended to multiple cancer centers. The invention and translation of new optical tools to Image Medicine is an enormous economic force today\, and the growth in science and technology opportunities and NIH funding within this field is discussed. \nBiography\nBrian W. Pogue\, Ph.D. is the MacLean Professor of Engineering at Dartmouth in Hanover\, New Hampshire USA\, and is Adjunct Professor in Surgery at the Geisel School of Medicine and Adjunct Professor of Life Science & Technology at Xi’an Jiaotong University\, China.  His Doctoral work in Physics from McMaster University\, Canada\, was followed by a Research Fellow position at the Wellman Center for Photomedicine at Harvard Medical School.  At Dartmouth since 1996\, he works in the area of Optics in Medicine\, with a focus on novel imaging systems for characterizing cancer and tracking therapy. Following being Dean of Graduate Studies at Dartmouth from 2008-2012\, he is now Director of MS and PhD Programs in Engineering Science & Medical Physics and coordinates the Center for Imaging Medicine.  He has published over 350 peer-reviewed papers and 400 conference papers in cancer therapy\, surgery\, medicine\, medical oncology\, and radiotherapy.  His research is funded by the NIH through two Program Project grants as well as several individual R01 grants. He is the Editor-in-Chief of the Journal of Biomedical Optics published by SPIE and is a Fellow of the International Society for Optics and Photonics (SPIE)\, the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineers (AIMBE).  He recently founded the startup company DoseOptics LLC\, making the world’s first camera to image radiotherapy dose delivery. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Matt Brenner URL:https://leadersinlight.com/event/brian-pogue-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/05/BrianPogue.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190425T120000 DTEND;TZID=UTC:20190425T130000 DTSTAMP:20260513T181604 CREATED:20190125T041910Z LAST-MODIFIED:20190404T234907Z UID:7355-1556193600-1556197200@leadersinlight.com SUMMARY:Xiaolin Nan\, PhD DESCRIPTION:Department of Biomedical Engineering\nOregon Health & Sciences University\nPortland\, Oregon \nVisualizing Tumor Biology: From Single Molecules to Systems\nCancer is a systems disease that arises from complex molecular abnormalities\, whereby effective treatment requires insight into tumorigenesis at multiple levels – from individual molecules to whole cells and tumors. Research in our laboratory aims to build multiscale\, systems-level models of tumorigenic signaling by leveraging recent developments in single-molecule\, superresolution\, and correlative light – electron microscopies. Using the human epidermal growth factor receptors (e.g. HER2) and the Ras small GTPases as model systems\, we will showcase how quantitative imaging at the single-molecule and nanometer scales reveals previously unknown aspects of these common oncogenic drivers. These findings underscore the importance of studying tumor biology within the intact spatial and biological context\, which current omics-based systems-biology approaches have largely overlooked. We will also discuss ongoing efforts toward constructing spatially-integrated models of tumorigenic signaling networks through multiplexed and high-throughput superresolution imaging\, as well as the implications of our findings in targeted cancer therapies. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Eric Potma URL:https://leadersinlight.com/event/xiaolin-nan-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/01/nan.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20190404T120000 DTEND;TZID=UTC:20190404T130000 DTSTAMP:20260513T181604 CREATED:20190125T025111Z LAST-MODIFIED:20190227T084914Z UID:7423-1554379200-1554382800@leadersinlight.com SUMMARY:Vincent Daria\, PhD DESCRIPTION:Applied Physics\nFellow\, Group Leader (Neuro-photonics Group)\nANU College of Health and Medicine\nAustralian National University Canberra\, AU \n  \nUsing Complex Light Patterns To Understand Brain Circuits\nWe aim to understand how information is processed in cortical circuits of the mammalian brain.  To achieve this\, we use complex light patterns to stimulate and record the activity of single cortical neurons in a rat brain slice.  We use holographic projection of an ultrafast laser to produce multiple foci\, where each focus emulates a synaptic input or an optical recording probe. To emulate synaptic inputs\, multiple foci are directed onto spines of a neuron and gated illumination enables localized two-photon (2P) photolysis of caged neurotransmitters. Patterned spatio-temporal release of neurotransmitters onto multiple spines allows us to study the input-output characteristics of single neurons in the cortex. As an optical recording probe\, each focus excites neuronal activity reporters via 2P multi-foci excitation.  The fluorescence emanating from all foci are simultaneously recorded using an electron-multiplying charge-coupled device (EMCCD) camera thereby enabling simultaneous multi-channel recording of the neuronal activity from multiple sites.  We report recording of neuronal activity from two types of reporters: (1) calcium indicator\, Cal520; and (2) voltage indicator\, JPW1114.  We optically recorded the activity evoked by the neuron following injection of current onto the soma. Using this technique\, we have uniquely identified a crucial function of a specific set of dendrites for learning and memory. Moreover\, we can disable such function by prunning the specific dendrite via highly targetted femtosecond laser dendrotomy. Using complex light patterns to understand the input-output transfer function of single neurons enables bottom-up approach to understand information processing in the brain. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.\nHosted by Dr. Daryl C Preece URL:https://leadersinlight.com/event/vincent-daria-phd/ LOCATION:BLI Library ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/01/daria.jpg END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20190327 DTEND;VALUE=DATE:20190401 DTSTAMP:20260513T181604 CREATED:20190127T000808Z LAST-MODIFIED:20190201T024816Z UID:7449-1553644800-1554076799@leadersinlight.com SUMMARY:ASLMS 2019 DESCRIPTION:Hear why you can’t miss ASLMS 2019. \nDenver\, Colorado March 27 -31\, 2019. Visit http://www.aslms.org/annual-conference-2019 to register. URL:https://leadersinlight.com/event/aslms-2019/ LOCATION:CA ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2019/01/FPEFtfga_400x400.png END:VEVENT END:VCALENDAR