BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Beckman Laser Institute - ECPv6.16.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Beckman Laser Institute
X-ORIGINAL-URL:https://leadersinlight.com
X-WR-CALDESC:Events for Beckman Laser Institute
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20180101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220726T130000
DTEND;TZID=America/Los_Angeles:20220726T140000
DTSTAMP:20260513T160546
CREATED:20220719T172002Z
LAST-MODIFIED:20220719T172002Z
UID:30717-1658840400-1658844000@leadersinlight.com
SUMMARY:Giulio Guagliumi\, M.D.
DESCRIPTION:Intervascular Imaging & Treatment Seminar \nAbout \nDr. Giulio Guagliumi was trained with Master in Interventional Cardiology at the Clinique Pasteur\, Toulouse\, France. He was awarded at Mayo Clinic and St. Mary Hospital\, Rochester in imaging and coronary physiology assessment of vascular response to intracoronary stents. He has a long-standing interventional practice with research expertise in acute myocardial infarction\, stent\, vascular biology\, intravascular imaging\, structural heart disease. Fellow of the Italian Society of Invasive Cardiology since 2003\, he was the Scientific Director of the GISE Congress in 2008-2009 and President of the Italian Society in 2009-2011. H’s fellow of the ESC\, member of EAPCI since 2004\, member of the scientific committee and executive board of EUROPCR; Co-chair EAPCI Program Scientific Committee for the ESC Congress 2012-2014: Expert Chair of the same Committee in 2015. Country champion of the European Stent for Life project in 2010-2014\, to correct inequalities in access to primary-PCI at Italian regional level. Promoter at the EAPCI level of the joint initiative with the largest Japanese society (CVIT). Professor emeritus 2013-2014 at the First Affiliated Hospital of Harbin Medical University. Since 2015\, Dr. Guagliumi was training the interventional cardiology unit personnel at the Second Affiliated Hospital of the Harbin Medical University in clinical use of the intracoronary imaging\, with focus on complex coronary artery disease. He worked as co-director with Prof. Yu and Prof. Jia in multiple national and international educational meetings held in Harbin\, including the most recent ASIA Pacific Hybrid Course on actionable imaging. He was appointed as Honorary Professor at the Harbin Medical University in 2019. \nDuring the COVID-19 disease period Dr. Guagliumi directed the Interventional Unit of PG23 Hospital\, working for all cardiovascular emergencies of the entire Bergamo Province. H’s the leading author of the COVID-19 pathology research publications that identified microthrombi as the major cause of myocardial damage. \nHe has ongoing scientific collaboration with major Universities and research centers including Beckmann Laser Unit\, University of California (Irvine)\, Case Western University (Cleveland\, Ohio)\, Emory University (Atlanta)\, MIT (Boston)\, CV Path Institute (Gaithersburg)\, Wakayama University (Japan)\, Harbin Medical University (China). Principal investigator and member of the Steering Committee in multiple prospective\, randomized\, international multicenter trials in primary-PCI\, coronary stenting\, DES\, intracoronary imaging (IVUS\, OCT). Author of 273 peer reviewed scientific manuscripts\, published across all prestigious cardiology journals\, including New England Journal\, Eur Heart Journal\, Lancet\, Circulation\, JACC\, JACC Imaging\, Eurointervention. He has more than 300 peer reviewed Abstracts presented at the main international scientific conferences. Reviewer of: Eur Heart Journal\, Circulation\, Circ Interv\, JACC\, JACC Interv\, JACC Imaging\, Nature Cardiovascular Medicine\, Eurointervention. Official grader of abstracts and clinical cases submitted to the main Congresses (EuroPCR\, ESC\, TCT\, TCT AP\, ENCORE etc). Dr. Guagliumi is the leading author of imaging chapters in multiple textbooks\, including the OCT chapter of the Interventional Cardiology Textbook- (Editor Topol-Teirstein) for the 6\, 7th\, 8th edition and now officially charged lead author for the new update #9 version. In 2014 he was listed by Thomson Reuters among the most influential researcher in the last ten years from inCites and the Web of Science. \n  \nBiography \nDr. Guagliumi research interest combines scientific and medical training\, expertise in conducting prospective\, randomized trials\, and leadership in the field of high-resolution imaging applied to evaluation of in-vivo stent vascular responses. Dr. Guagliumi a pioneer in clinical use of light-based imaging for evaluating coronary stenting in various prospective\, randomized\, controlled studies conducted in unstable coronary syndromes\, including ST elevation myocardial infarction\, and complex lesion settings (long lesions\, diabetes\, overlapping stents). His group has one of the largest existing experience in the world with Optical Coherence Tomography (OCT) to detect stent-tissue responses at different time points following implantation. His work is based on continuous confront and interaction with pathologists for validating OCT imaging signals  and interpretation and develop surrogate imaging variables predicting stent failure. With this as a foundation the Guagliumi laboratory set the way for conducting innovative in-vivo evaluation and optimization of most of the clinically approved bare metal and drug-eluting stents. H’s involved in early evaluation/discussion of light based technical and software innovations for the clinical use\, including OCT co-registration with coronary angiography\, novel artificial intelligence software implementation for automatic EEL detection and calcium quantification. His most recent publications have focused on how light-based intracoronary imaging helps to identify heterogeneous mechanisms of stent thrombosis and define surrogate imaging variables for anticipating the individual risk profile. Dr. Guagliumi is involved in innovative invasive and non invasive imaging and physiology research projects\, including the use of the light for plaque molding\, and innovative blood flow measurements with CTCA. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n 
URL:https://leadersinlight.com/event/giulio-guagliumi-m-d/
LOCATION:Zoom Event\, CA\, United States
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/07/profile_photo.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220523T120000
DTEND;TZID=UTC:20220523T130000
DTSTAMP:20260513T160546
CREATED:20220515T163102Z
LAST-MODIFIED:20220515T163335Z
UID:30522-1653307200-1653310800@leadersinlight.com
SUMMARY:Michelle Digman\, Ph. D.
DESCRIPTION:FLIM and Mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells \nAbstract \nThe hallmark of metabolic alteration of increase glycolysis\, i.e. Warburg effect\, in cancer cells together with atypical extracellular matrix structure may be responsible for tumor cell aggressiveness and drug resistance. While it is it known that tumor cells stiffen the ECM as the tumor progression occurs\, a direct relationship between ECM stiffness and altered metabolism has not been explicitly measured. Here we apply the phasor approach technique in fluorescence lifetime imaging microscopy (FLIM) to measure metabolic alteration as a function of ECM mechanics. We imaged and compared triple-negative breast cancer (TNBC) cells to non-cancerous cells on various ECM stiffness. Our results show that TNBC exhibit a decreased fraction of bound NADH\, (indicative of glycolysis\,) with increasing substrate stiffness. All other cell lines showed little to no change in fraction bound NADH on the varying collagen densities. Dysregulation of mitochondrial motion may contribute to the fueling of bioenergy demands in metastatic cancer. To measure mitochondria motion and analyze their fusion and fission events\, we developed a new algorithm called “mitometer” that is unbiased\, and allows for automated segmentation and tracking of mitochondria in live cell 2D and 3D time-lapse images. Together\, the automated segmentation and tracking algorithms and the innate user interface make Mitometer a broadly accessible tool.? \n  \nBiography \nDr. Digman was awarded a doctorate degree in Chemistry with specialization in Biochemistry from the University of Illinois at Chicago in 2003. She did her postdoctoral work in the Department of Physics at the University of Illinois at Urbana-Champaign in biophysics until this lab moved to the University of California Irvine. She became Optical Bio-Core Director until she joined the BME department in 2013. Her research lab is focused on developing novel biophysical and optical tools to study biological questions with the goal of applying the gained knowledge to the advancement of human medicine. Dr. Digman is AIMBE Fellow\, Scialog Fellow\, Allen Distinguished Investigator in Immunometabolism\, and has won several awards including the NSF-CAREER award\, the Hellman Fellowship\, the Fluorescence Young Investigator Award from the Biophysical Society\, the Faculty Innovation in Teaching award and has received the Henry Samueli Career Development Chair \n  \nREGISTER HERE
URL:https://leadersinlight.com/event/michelle-digman-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/05/Digman.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220411T120000
DTEND;TZID=UTC:20220411T130000
DTSTAMP:20260513T160546
CREATED:20220403T121058Z
LAST-MODIFIED:20220403T121821Z
UID:30476-1649678400-1649682000@leadersinlight.com
SUMMARY:Alvin Viray\, J.D.
DESCRIPTION:Technology Transfer and Entrepreneurship at UCI \nAbstract \nThis seminar will discuss “technology transfer”\, the process by which UCI (1) protects intellectual property (inventions and software) developed by its faculty\, staff\, researchers and grad students; and (2) commercializes this IP through licensing to an existing company or startup. Also discussed will be the services and resources at UCI’s Beall Applied Innovation for entrepreneurs willing to form a startup based upon the intellectual property they develop at UCI. If you are currently developing intellectual property (IP) at UCI\, would like to do so\, and/or are curious about entrepreneurship and startups\, this seminar will seek to answer any and all your questions: How to submit your invention/software to UCI’s technology transfer office (aka “Research Translation Group”); Who owns my intellectual property; How much do inventors get from UCI’s licensing deal; What is the services and resources are available to me as an entrepreneur doing a startup? \n  \nBiography \nAlvin Viray is the Associate Director of UC Irvine’s technology transfer office\, known as the Research Translation Group (RTG) at UCI’s Beall Applied Innovation. Alvin and his team receives and manages inventions developed by UCI’s faculty\, physicians\, and researchers. He reviews new invention disclosures for patentability and commercial viability. He negotiates and executes various intellectual property agreements on behalf of UCI\, including license agreements for startups and companies. A licensed patent attorney\, Alvin graduated from the University of San Diego School of Law before passing the California Bar and USPTO Patent Bar. Alvin received his bachelor’s from UCI where he frequently guest lectures on topics covering Patents\, Copyrights\, Trademarks\, Licensing\, and Startups. \n  \nREGISTER HERE
URL:https://leadersinlight.com/event/alvin-viray-j-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/04/Alvin-Viray.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220331T120000
DTEND;TZID=UTC:20220331T130000
DTSTAMP:20260513T160546
CREATED:20220321T225034Z
LAST-MODIFIED:20220403T121006Z
UID:30470-1648728000-1648731600@leadersinlight.com
SUMMARY:David A. Chalyan\, MD\, MSc
DESCRIPTION:Opportunities to Improve Clinical Outcomes with Intravascular Ultrasound (IVUS) in Lower Extremity Revascularizations \nAbstract \nPeripheral vascular disorders are prevalent and mounting health conditions\, particularly in light of the aging population. Both acute and chronic arterial and venous disease result in excess morbidity and mortality and dramatically reduce health-related quality of life. Yet\, despite the expanded indications in guidelines for the types and complexities of vascular lesions resulting in a rising volume of endovascular interventions in general\, we have not seen a meaningful impact on clinical outcomes like amputation rates\, which continue to increase despite better access to peripheral vascular procedures. With the known health outcome benefits of Intravascular Ultrasound (IVUS) in coronary applications and the much higher reintervention rates in peripheral vascular procedures\, the uptake of IVUS has been increasing in lower extremity revascularizations. In this seminar\, we examine the up-to-date evidence\, cross-disciplinary consensus and emerging Real-World Data (RWD) for the role of IVUS in peripheral interventions in order to provide guidance on where this invasive imaging modality may be most beneficial to improve the quality of patient care during lower extremity arterial and venous intervention. \n  \nBiography \nDavid A. Chalyan received his Doctor of Medicine degree from Roy J. and Lucille A. Carver College of Medicine at the University of Iowa and his Master of Science degree in Biomedical Engineering from the University of California\, Irvine where he studied invasive coronary hemodynamics\, angiography-based Fractional Flow Reserve\, and diastolic Fractional Flow Reserve. He currently holds a position in Philips Chief Medical Office \n  \nREGISTER HERE
URL:https://leadersinlight.com/event/david-a-chalyan-md-msc/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/03/Chalyan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220310T120000
DTEND;TZID=UTC:20220310T130000
DTSTAMP:20260513T160546
CREATED:20220301T192752Z
LAST-MODIFIED:20220301T192752Z
UID:30462-1646913600-1646917200@leadersinlight.com
SUMMARY:Dr. Maxim R. Shcherbakov\, Ph. D.
DESCRIPTION:Tunable photonic nanostructures for laser pulse control and dynamic imaging \nAbstract \nFor decades\, nanofabrication has been the driving force behind the transformations in electronics. Light-based devices currently experience a similar transition: nanostructure-based photonic elements bear promise to revolutionize several key technology areas\, such as telecommunications\, augmented reality\, remote sensing\, and imaging. In this talk\, I will introduce the concept of tunable photonic nanostructures\, where time can be leveraged as an additional degree of freedom to manipulate the flow of light on demand. In a multi-faceted study\, we will explore how silicon-based nanostructures can be used as ultrafast all-optical switches that can control light with light at subpicosecond timescales and record-low Joule-per-bit counts. Next\, by marrying designer nanostructures to a technologically mature switching agent\, liquid crystals\, we will demonstrate the world’s thinnest lens with an electrically tunable focal spot. We will conclude on remarks how our technology enables lightweight and compact imaging solutions for spatial light modulators\, mixed reality glasses\, head-on displays\, and microscopes\, and outline its potential biomedical applications. \n  \nBiography \nMaxim Shcherbakov is an assistant professor at UCI EECS. He was a postdoctoral associate with the School of Applied and Engineering Physics at Cornell University from 2016 to 2021. He received his M.S. and Ph.D. degrees in Physics from Lomonosov Moscow State University\, Russia. As a deputy group leader at Samsung Advanced Institute of Technology\, his research was focused on wearable electronics\, remote sensing\, and LiDARs. He is an author of more than 50 research papers and book chapters\, and recipient of awards in photonics\, telecommunications and nanotechnology. \n  \nREGISTER HERE
URL:https://leadersinlight.com/event/dr-maxim-r-shcherbakov-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2022/03/Maxim-R.-S.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220303T130000
DTEND;TZID=UTC:20220303T140000
DTSTAMP:20260513T160546
CREATED:20220216T231932Z
LAST-MODIFIED:20220222T233335Z
UID:30392-1646312400-1646316000@leadersinlight.com
SUMMARY:Dr. Lilangi Ediriwickrema\, M.D.
DESCRIPTION:Applications of Spatial Frequency Domain Imaging in Thyroid Eye Disease \nAbstract \nSpatial frequency domain imaging provides access to multi-spectral absorption and scattering information of biological chromophores and water to provide quantifiable detail about tissue hemodynamics and spectral content. We propose to use SFDI to define an optical signature map characteristic for healthy eyes\, and TED before\, during\, and after treatment. We will use this information to establish clinical end-points and understand strategies to modulate hemodynamics\, osmotic gradients\, and collagen remodeling. \n  \nBiography \nDr. Lilangi Ediriwickrema is a board-certified UCI Health ophthalmologist who specializes in ophthalmic plastic and reconstructive surgery\, neuro-ophthalmology and orbital disease. \nShe received her medical degree from the Yale School of Medicine in New Haven\, Conn. She completed an internship at Memorial Sloan Kettering Cancer Center in New York City and a residency in ophthalmology at the Keck School of Medicine of USC\, where she was chief resident. She also completed a fellowship in neuro-ophthalmology and orbital disease at Johns Hopkins University’s Wilmer Eye Institute in Baltimore\, Md.\, followed by fellowship training in ophthalmic plastic and reconstructive surgery at the Shiley Eye Institute at UC San Diego Health. \n  \nREGISTER HERE
URL:https://leadersinlight.com/event/dr-lilangi-ediriwickrema-m-d/
LOCATION:Zoom Event\, CA\, United States
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/02/Dr.-Lilangi-Ediriwickrema.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220224T120000
DTEND;TZID=UTC:20220224T130000
DTSTAMP:20260513T160546
CREATED:20220214T211746Z
LAST-MODIFIED:20220214T214408Z
UID:30368-1645704000-1645707600@leadersinlight.com
SUMMARY:Dr. Dmitri Lapotko\, Ph.D.\, D.Sc.
DESCRIPTION:Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles \nAbstract\nTo improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer\, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale\, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event\, plasmonic nanobubble\, results from a novel physical-biological mechanism. Its mechanical impact was tuned to support cell level diagnostics\, drug release and intracellular injection of genetic or therapeutic payloads\, to enhance chemoradiation therapies in highly resistant and aggressive tumors\, to intraoperatively detect and destroy unresectable residual microtumors\, and to non-invasively detect bad actors\, all in personalized procedures with safe doses of nanoparticles and laser energies. Plasmonic nanobubble platform can be integrated with current or novel medical approaches to improve clinical outcomes where standards of care fail. \nBiography\nDmitri Lapotko obtained his MS in thermal physics and Ph.D. in laser applications from Belarus State University and Doctor of Science in bioengineering from Lyikov Heat and Mass Transfer Institute. His research in biophotonics and nanotechnology in basic\, applied and clinical science resulted in the invention of photothermal microscope for functional analysis of live cells\, laser-generated vapor nanobubbles (plasmonic nanobubbles) as a novel platform for diagnostic\, therapeutic and surgical technologies for cancer\, malaria and cardiovascular disease applications. \n  \nREGISTER HERE \n 
URL:https://leadersinlight.com/event/dr-dmitri-lapotko-ph-d-d-sc/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/02/Dmitri-Lapotko.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20211216T120000
DTEND;TZID=UTC:20211216T130000
DTSTAMP:20260513T160546
CREATED:20211208T055702Z
LAST-MODIFIED:20211208T055807Z
UID:30087-1639656000-1639659600@leadersinlight.com
SUMMARY:Song Hu\, Ph. D.
DESCRIPTION:Light + Sound: Peering into Brain Function and Metabolism \nAbstract\nExploiting the optical absorption contrast of blood hemoglobin\, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature\, which plays an essential role in supplying oxygen to the biological tissue and maintaining the metabolic activity in vivo. The multi-parametric PAM developed in Dr. Hu’s lab enables\, for the first time\, comprehensive and quantitative characterization of the microvascular structure\, function\, and associated tissue oxygen metabolism at the microscopic level. In this seminar\, Dr. Hu will present their latest progress on the development of PAM and the integration of PAM with other intravital light microscopy techniques for studying brain function and energy metabolism. \nBiography\nDr. Hu received his B.S. and M.S. degrees in Electronic Engineering from Tsinghua University and Ph.D. degree in Biomedical Engineering from Washington University in St. Louis. His research focuses on the development of photoacoustic and optical technologies for high-resolution structural\, functional\, metabolic\, and molecular imaging in vivo. Dr. Hu has published over 70 peer-reviewed articles in journals including Science\, Nature\, Nature Neuroscience\, and Proceedings of the National Academy of Sciences\, and has delivered over 40 invited talks including a Neurotechnologies plenary talk at Photonics West (2018) and a President’s Symposium keynote talk at Annual Microcirculatory Society Meeting (2018). His publications\, including the 4th and 6th most cited articles in the Journal of Biomedical Optics since 2009 and the 5th most cited article in Optics Letters since 2007\, have accumulated around 9\,000 citations (h-index: 37). Dr. Hu is a recipient of the Ralph E. Powe Junior Faculty Enhancement Award (2014)\, the National Science Foundation Faculty Early Career Development (NSF CAREER) Award (2018)\, and the Chan Zuckerberg Initiative Frontiers of Imaging Award (2020). \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/song-hu-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/12/Song-Hu.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20211202T120000
DTEND;TZID=UTC:20211202T130000
DTSTAMP:20260513T160546
CREATED:20211130T053721Z
LAST-MODIFIED:20211130T053721Z
UID:30060-1638446400-1638450000@leadersinlight.com
SUMMARY:Wenbin Tan\, Ph. D.
DESCRIPTION:Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations \nAbstract\nSARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular\nabnormalities in Port Wine Stains. In the first part\, we will present our clinical data for the first discovery of dyslipidemia\nin COVID-19 patients which have been substantially recognized. Mechanistically\, we have shown evidence of niche why\nobese subjects are more vulnerable to SARS-CoV-2 attack. Using a spike protein–pseudotyped (Spp) lentivirus with the\nproper tropism of the SARS-CoV-2 spike protein on the surface\, we have found that Spp lentiviruses preferably attack to\nendothelial cells in heart in obese but not normal weight mice\, leading to exaggerated vasculopathy and cardiomyopathy.\nCells with over-expression of Spike protein have impaired lipid metabolic and autophagy formation pathways\, resulting in\nincreased cell death in response to lipotoxicity. In the second part\, we will discuss the clinical molecular pathology of\ninfantile and early childhood PWS to show that (1) PWS is a disease with pathological alterations involving the entire skin\nphysiological milieu; (2) pluripotent cells with the GNAQ (R183Q) may give rise to multilineages in PWS; and (3) exocytosis\nof extracellular vesicles is enhanced in PWS vasculatures. \nBiography\nDr. Tan received his medical degree and master degree in Molecular Biology from XiangYa School of Medicine\, China. He\nreceived his PhD in neurobiology and neurophysiology from University of California\, Los Angeles. He joined Beckman\nLaser Institute at UC Irvine as an assistant project scientist in 2010 under the mentorship of Dr. Stuart Nelson. In 2018\,\nhe joined the department of cell biology and anatomy at School of Medicine University of South Carolina as an associate\nprofessor. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/wenbin-tan-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/11/Wenbin-Tan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20211014T120000
DTEND;TZID=UTC:20211014T130000
DTSTAMP:20260513T160546
CREATED:20211014T005755Z
LAST-MODIFIED:20211014T010429Z
UID:29834-1634212800-1634216400@leadersinlight.com
SUMMARY:Erin Buckley\, Ph. D.
DESCRIPTION:Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies \nAbstract\nOur research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive\, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar\, I will focus on our recent work that uses these tools to identify biomarkers of stroke risk in two high-risk patient populations; subarachnoid hemorrhage and pediatric sickle cell disease. Moreover\, I will talk about how we have advanced the techniques to account for the confounding influences of hematocrit in the sickle cell cohort. \nBiography\nDr. Buckley is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. She is also an assistant professor at the Department of Pediatrics at Emory University. She received her PhD from the Department of Physics and Astronomy from the University of Pennsylvania in 2011 and completed postdoctoral training at the Children’s Hospital of Philadelphia and at Massachusetts General Hospital. Her research focuses on the development and validation of diffuse optical spectroscopies. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/erin-buckley-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/10/Dr-Buckley-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20211007T120000
DTEND;TZID=UTC:20211007T130000
DTSTAMP:20260513T160546
CREATED:20220608T191355Z
LAST-MODIFIED:20220608T191355Z
UID:30597-1633608000-1633611600@leadersinlight.com
SUMMARY:Quinton Smith\, Ph. D.
DESCRIPTION:Harnessing Physiological Forces to Drive Stem Cell Fate & Function \nAbstract\nI will be elaborating about how physical cues are crucial to embryonic development\, morphogenic events\, and tissue organization\, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such\, the role of substrate stiffness\, fluid shear stress\, and confinement was interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates\, as opposed to traditionally used rigid plastic surfaces\, promotes efficient endothelial specification in the absence of growth factor supplementation. Leveraging micropatterned domains\, which restrict extracellular matrix accessibility\, also enhances endothelial specification and early lineage organization. Finally\, using a microfluidic platform\, we find that primary cilia\, a microtubule-based mechanosensor\, is crucial to stem cell derived endothelial shear response. Collectively\, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools. \nBiography\nQuinton Smith is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Sue & Bill Gross Stem Cell Research Center\, Irvine. Quinton Smith received his bachelor’s degree from the University of New Mexico in\nchemical engineering and his Ph.D. in 2017 from Johns Hopkins University in chemical and biomolecular engineering. His predoctoral research was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. Additionally\, he was named a Siebel Scholar in 2017. After completing his doctorate\, he trained as a Howard Hughes Medical Institute Hanna Gray Postdoctoral Fellow at the Massachusetts Institute of Technology. Dr. Smith joined the University of California Irvine in Spring 2021 and is currently an Assistant Professor in the Department of Chemical and Biomolecular Engineering and a member of the Sue Bill Gross Stem Cell Research Center. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/quinton-smith-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Quinton_Smith.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210923T120000
DTEND;TZID=UTC:20210923T130000
DTSTAMP:20260513T160546
CREATED:20220608T193312Z
LAST-MODIFIED:20220608T193312Z
UID:30609-1632398400-1632402000@leadersinlight.com
SUMMARY:Andy Shih\, Ph. D.
DESCRIPTION:Optical Dissection of Brain Capillary Function \nAbstract\nMy laboratory uses in vivo multiphoton imaging and rodent models to shed light (quite literally) on regulation of cerebral blood flow. In particular\, we have focused recent attention on the vast capillary networks that distribute blood throughout the brain. We use light to both visualize capillary structure and flow\, as well as noninvasively manipulate neurovascular cells that control capillary flow. We specialize in the application and development of in vivo multi-photon imaging approaches to study brain microvascular structure and function in rodents. Our recent findings include the construction of capillary networks during early postnatal development\, regulation of blood flow in adulthood by capillary pericytes\, and capillary changes in gray and white matter that may contribute to metabolic insufficiencies during aging and dementia. I firmly believe that our efforts will provide a unique and physiologically relevant view of microvascular function\, dysfunction\, and repair\, and will yield strategies for protecting vascular function in diseases that degrade the brain’s microvasculature. \nBiography\nAndy Shih is an Assistant Professor in the department of Developmental Biology & Regenerative Medicine at Seattle Children’s Research Institute. Additionally\, he is an assistant professor in the Department of Bioengineering and Department of Pediatrics at the University of Washington. His research focuses on optogenetic approaches to manipulate pericyte contractility in the intact brain\, and studies to delineate pathological features of mural cells in advanced age and small vessel disease. Shih earned a B.S. in Cell Biology and genetics from the University of British Columbia (2010) and Ph.D. in Neuroscience. He has completed his postdoc and been a project scientist from University of California\, San Diego (2012). Shih has been invited to several symposiums and been part of the SfN Nanosymposium chair (Stroke and Injury\, 2016) where he elaborates about his extensive findings & projects. A complete list of his published works in Google Scholar & NIH Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=andy+y+shih \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/andy-shih-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/shih.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210819T120000
DTEND;TZID=UTC:20210819T130000
DTSTAMP:20260513T160546
CREATED:20210810T020201Z
LAST-MODIFIED:20210810T020417Z
UID:29697-1629374400-1629378000@leadersinlight.com
SUMMARY:Stacy Copp\, Ph. D.
DESCRIPTION:Fluorophores with a Genome: DNA-Stabilized Silver Clusters as a New Class of Tunable Fluorophores for Microscopy and Biosensing \nAbstract\nBecause near-infrared (NIR) electromagnetic radiation penetrates much farther into biological tissues than visible light\, NIR microscopy allows for noninvasive imaging deep into tissues and even whole organisms. In the second near-infrared window (NIR-II: 1\,000-1\,700 nm)\, biological tissues are transparent up to several centimeters depth. However\, fluorescence microscopy in this spectral window has been limited by the dearth of small\, bright\, and nontoxic NIR-II fluorophores. To address this challenge\, we are investigating a promising class of nanomaterials – DNA-templated silver clusters (Ag-DNAs) – to develop small\, stable\, and modular NIR-II biolabels with broad applicability for deep tissue imaging. Ag-DNAs represent a diverse palette of fluorophores with sequence-encoded sizes of 10-30 atoms and fluorescence emission wavelengths of 400 – 1\,000 nm. I will discuss our growing understanding of the fundamental properties of Ag-DNAs and our development of a high throughput experimental platform coupled with machine learning frameworks to guide discovery of Ag-DNAs within the NIR spectral windows. Using this approach\, we are expanding the color palette of Ag-DNAs well into the NIR\, with exciting future potential to enable deep tissue imaging applications. \nBiography\nStacy Copp is an Assistant Professor of Materials Science and Engineering at the University of California\, Irvine\, where she holds the Samueli Faculty Development Chair and courtesy appointments in the Departments of Physics and Astronomy and Chemical and Biomolecular Engineering. Her research focuses on harnessing information-encoding macromolecules – DNA\, peptides\, and block copolymers – as building blocks for novel optical and electronic materials. Due to the complexity of these molecular materials\, her work incorporates machine learning and data mining for materials study and design. Copp earned a B.S. in physics and mathematics from the University of Arizona (2011) and Ph.D. in physics from UC Santa Barbara. Before joining UCI in 2019\, she was a Hoffman Distinguished Postdoctoral Fellow at Los Alamos National Laboratory (LANL). Copp’s research has been recognized by awards including the AFOSR Young Investigator (2020)\, L’Oreal USA for Women in Science Fellowship (2018)\, and numerous postdoctoral and graduate fellowships.  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/stacy-copp-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/08/STACY_2-copy-300x300-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210729T120000
DTEND;TZID=UTC:20210729T130000
DTSTAMP:20260513T160546
CREATED:20220608T192629Z
LAST-MODIFIED:20220608T192629Z
UID:30605-1627560000-1627563600@leadersinlight.com
SUMMARY:Herdeline (Digs) Ardoña\, Ph. D.
DESCRIPTION:Hierarchical Strategies Towards Biointerfacing With Soft Optoelectronic Materials  \nAbstract\nThe applications of functional nanomaterials towards biological interfacing continue to emerge in various fields\, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems\, these biomaterials are rarely synthesized with optical and electronic functionalities that could be beneficial for controlling the behavior of excitable cells (e.g.\, neurons and cardiac cells) or for biosensing applications. In this seminar\, I will first describe the development of one-dimensional peptidic nanostructures appended with organic electronic units\, which can facilitate photoinduced energy transfer under aqueous environments. These semiconducting peptide monomers that self-assemble as aligned hydrogels are successfully built according to design principles that allowed for directed photonic energy transport\, sequential electron transport in a multicomponent system\, and transmission or equilibration of voltage or current when incorporated in a transistor device. These soft scaffolding materials\, with tunable molecular to macroscale properties\, offer a unique tissue engineering platform that can locally and synergistically deliver electronic\, topographical\, and biochemical cues to cells. In the second part of the talk\, I will describe how to engineer in vitro models of cells and tissues which enables the understanding of nano-bio or abiotic-biotic interactions at multiple spatial scales. I will specifically describe physiologically relevant models that faithfully recapitulate the native form and function of cells or tissues involved in the systemic biodistribution of common nanomaterials—across biological barriers to target organs. These testing platforms were used to elucidate the dynamic structural and functional outcomes resulting from the exposure of vascular endothelium and myocardium to engineered nanomaterials. Finally\, this presentation will discuss the future applications of biopolymer assemblies with photonic and electronic functionalities as tools for controlling cellular processes and probing biophysical phenomena\, such as mechanotransduction and drug/toxicant permeation across tissues. \nBiography\nHerdeline Ann (Digs) M. Ardoña is originally from Valenzuela City\, Philippines. She received her B.S. in Chemistry (summa cum laude) from the University of the Philippines Diliman in 2011. In 2017\, she completed her Ph.D. in Chemistry at Johns Hopkins\, with funding support from Schlumberger Foundation and Howard Hughes Medical Institute. Her dissertation was focused on understanding the molecular design\, photophysical properties\, and supramolecular principles towards developing pi-conjugated peptide assemblies as bioelectronic nanomaterials. She then worked as a postdoctoral researcher in the Disease Biophysics Group at the Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences at Harvard University. As the 2018-2020 ACS Irving S. Sigal Postdoctoral Fellow\, she investigated the structural and functional impacts of multiple engineered nanomaterials through microphysiological platforms and biohybrid models. Digs started as an Assistant Professor at the UCI Department of Chemical and Biomolecular Engineering in Fall 2020. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/herdeline-digs-ardona-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Ardona_Photo.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210617T120000
DTEND;TZID=UTC:20210617T130000
DTSTAMP:20260513T160546
CREATED:20220608T192056Z
LAST-MODIFIED:20220608T192056Z
UID:30601-1623931200-1623934800@leadersinlight.com
SUMMARY:Philip Scumpia\, Ph. D.
DESCRIPTION:Translating an understanding of the cutaneous microenvironment into diagnostics and treatments for wounds\, cancers\, and inflammatory dermatoses \nAbstract\nImmune cells are the first responders to injury\, pathogens\, or malignancy. The various components of the tissue microenvironment dictate what immune cells do when they reach different tissues. The Scumpia lab studies how different components of the unique cutaneous microenvironment affect outcome following wounding\, bacterial infection\, or cancer. The overall goal is to develop an understanding of the cutaneous microenvironment regulates skin disease and to translate this knowledge into new diagnostics and therapies. \nBiography\nDr. Scumpia received a BS in Microbiology and Cell Sciences from the University of Florida. He received his M.D. and PhD. from the University of Florida where he studied the immunobiology of sepsis. He completed his residency and fellowship training in Dermatology and Dermatopathology at UCLA. He is currently an Assistant Professor in the Department of Medicine at UCLA where he studies how various components of the cutaneous microenvironment including nerves\, lipids\, and extracellular matrix\, regulate skin diseases. The goal is to translate this understanding into novel diagnostics and potential therapeutics. He is currently a member of the American Academy of Dermatology and the Society of Investigative Dermatology. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/philip-scumpia-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Scumpia.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210506T090000
DTEND;TZID=UTC:20210506T100000
DTSTAMP:20260513T160546
CREATED:20210416T041739Z
LAST-MODIFIED:20210416T041739Z
UID:29270-1620291600-1620295200@leadersinlight.com
SUMMARY:Dan Cojoc\, Ph. D.
DESCRIPTION:Cell Mechanics by Light \nAbstract\nLiving cells are active matter characterized by mechanical properties as stiffness and deformability and morphological parameters as shape and volume. Genetic or pathogenic modifications of these properties can affect cell behavior. Since these transformations are potential indicators in various pathologies\, cell mechanics characterization has progressively gained interest.  However\, due to their variability it is difficult to establish absolute values for these properties\, especially when different measurement methods are applied. In the first part\, I will discuss this issue presenting results obtained with Optical Tweezers (OT)\, Atomic Force Microscopy (AFM) and Digital Holographic Microscopy (DHM) and showing that using more than one type of cell allows to confront the methods\, confirm the results and cell behavior. Cells can detect and respond to pressure and forces exerted by the cellular environment in various forms. Thus\, mechanosensitive signaling pathways are activated\, inducing cytoskeleton reshaping and force generation as a response to these mechanical stimuli. How big and how much localized is the force inducing a mechanical stimulation\, and what is its time extent? These questions are still to be elucidated. In the second part of the talk\, I will argue on the use of OT as an adequate tool to study cell mechanotransduction. Using a novel OT setup\, mechanical stimuli are applied under controlled conditions\, the force and indentation of which are measured directly and precisely. Neuronal cells are locally stimulated with piconewton forces which trigger Ca2+ transients in the cell and induce cytoskeletal modifications. \nBiography\nDr. Dan Cojoc is a Senior Scientist at the Institute of Materials of the National Research Council of Italy (CNR). With a background in Optical Engineering (M.S.) and Technical Physics (Ph.D.) from the University “Politehnica” of Bucharest\, Romania\, he has contributed to develop microscopy devices and techniques for applications in nanotechnology and biophysics. He has created various optical tweezers setups for sample manipulation and force measurements and integrated them with X-ray diffraction\, holographic microscopy\, laser microsurgery and fluorescence imaging for the study of biological samples. Currently\, Dr. Cojoc’s laboratory applies optical tweezers and digital holographic microscopy techniques to probe cell mechanics of blood\, cancer and neuronal cells. The interaction of light with the matter is exploited to apply tiny forces to cells and measure their local deformations to derive the mechanical properties or examine mechanotransduction mechanisms. Dr. Cojoc has been engaged in several interdisciplinary projects and has been awarded with research grants and fellowships from Italy\, Croatia\, Spain\, Germany\, France\, Romania and China. He published more than 130 papers\, keeps 3 patents\, is co-author of 11 chapter books and reviewer for more than 10 scientific journals. Dr. Cojoc is an adjunct professor at the University of Trieste and at the International School of Advanced Studies (SISSA) Trieste\, lecturing Experimental Biophysics and Advanced Optical Microscopy courses for undergraduates and tutoring PhD students in Nanotechnology and Neurobiology programs.  \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/dan-cojoc-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/04/Dan-Cojoc.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210422T120000
DTEND;TZID=UTC:20210422T130000
DTSTAMP:20260513T160546
CREATED:20210416T014528Z
LAST-MODIFIED:20210416T014528Z
UID:29266-1619092800-1619096400@leadersinlight.com
SUMMARY:Nozomi Nishimura\, Ph. D.
DESCRIPTION:In vivo multiphoton microscopy of microvasculature and inflammation: Lessons from the brain and a look at the heart  \nAbstract\nIn vivo multiphoton microscopy enables the visualization of dynamics at the cellular scale and is an ideal tool for studying the interactions of cells in vivo. Such imaging has revealed the importance of maintaining vascular health\, even in the smallest blood vessels and the capillary bed. In an example in the brain\, we found in mouse models of Alzheimer’s disease (AD)\, that stalled blood flow in a small number of capillaries caused by neutrophils plugs had a surprisingly large effect on total blood flow. Rescue of blood flow led to rapid improvements in short-term memory. We also used laser-induced lesions to study the effects of small-vessel occlusions on inflammation and on amyloid-beta deposits. We discovered rapid alterations in plaques\, both dissolution and increase in deposits\, that were previously thought to be stable structures. We recently adapted these experimental capabilities to organs with motion including the heart. In models of heart failure\, intravital imaging of cardiac vasculature suggests that leukocyte obstruction of capillaries may play a role in the disease. Intravital vital imaging also enables measurements of calcium dynamics and contraction in cardiomyocytes and concurrent dynamics in inflammatory cells. \nBiography\nNozomi Nishimura is an Associate Professor in the Meinig School of Biomedical Engineering at Cornell University and develops optical tools for studying in vivo cell behaviors in disease. Her PhD is in physics from the University of California at San Diego with Prof. David Kleinfeld where she studied blood flow in the brain of rodents and developing laser-based models of small stroke. She came to Biomedical Engineering at Cornell in 2006 to do a postdoc with Prof. Chris Schaffer and later joined the faculty in 2013.To study the complex actions of cells in vivo\, her lab develops intravital multiphoton microscopy imaging methods that reveal how cells function\, move and interact. Injury triggers the recruitment and activation of many immune and inflammatory cell types that\, together with the local cells\, determine the course of the disease progression. The goal is to develop methods to visualize all of these cells at once and quantify cell actions and function. She applies these tools in many systems\, but has particular interests in studying the effects of microvascular dysfunction in the brain. Her lab studies the role of microvascular occlusions in Alzheimer’s disease and neurodegeneration. These methods were recently adapted for the beating mouse heart providing new capabilities to study single cell function and cardiac microvasculature. Recent work expanding into the intestine revealed novel behaviors such as motion and force actuation by stem cells in response to injury.\nSponsored by the Berns Family LAser and Microbeam Program \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/nozomi-nishimura-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/04/Nishimura.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210401T120000
DTEND;TZID=UTC:20210401T130000
DTSTAMP:20260513T160546
CREATED:20210225T054811Z
LAST-MODIFIED:20210225T055556Z
UID:29190-1617278400-1617282000@leadersinlight.com
SUMMARY:Ji-Xi Cheng\, Ph. D.
DESCRIPTION:Harnessing Photons for Label-free Chemical Imaging\, High-Precision Neuromodulation\, and Killing of Superbugs  \nAbstract\nPhotons are unique in that they can directly interact with molecules\, the foundation of life. I will give an overview of our biophotonics research at three levels of interactions. At the weak interaction regime\, I will present label-free chemical microscopy utilizing spectroscopic signals for discovery of molecular signatures related to cancer aggressiveness and antimicrobial resistance. At the moderate interaction regime\, I will present non-genetic high-precision optoacoustic stimulation of nervous system. At the strong interaction regime\, I will show that photolysis of intrinsic chromophores could effectively sensitize resistant pathogens to antibiotics and anti-fungal drugs. \nBiography\nJi-Xin Cheng is currently the Inaugural Theodore Moustakas Chair Professor in Photonics and Optoelectronics at Boston University. Cheng and his team are constantly at the forefront of chemical imaging in innovation\, discovery\, commercialization\, and clinical translation. For his pioneering contributions to the field of vibrational spectroscopic imaging\, Cheng received the 2020 Pittsburg Spectroscopy Award from the Spectroscopy Society of Pittsburg\, the 2019 Ellis R. Lippincott Award from OSA\, Society for Applied Spectroscopy\, Coblentz Society\, and the 2015 Craver Award from Coblentz Society. Cheng is authored in over 270 peer-reviewed articles with an h-index of 79 (Google Scholar). His research has been supported by over 30 million ($) fund from federal agencies including NIH\, NSF\, DoD\, DoE and private foundations including the Keck Foundation. Cheng is a Fellow of Optical Society of America\, a Fellow of American Institute of Medicine and Biological Engineering\, and associate editor of Science Advances. \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/ji-xi-cheng-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/02/Ji-Xin-Cheng-Headshot.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20210324T100000
DTEND;TZID=UTC:20210324T110000
DTSTAMP:20260513T160546
CREATED:20210220T050239Z
LAST-MODIFIED:20210220T050956Z
UID:29168-1616580000-1616583600@leadersinlight.com
SUMMARY:Dr. Christoph Hitzenberger\, Ph. D.
DESCRIPTION:From Ocular Biometry to Cellular Resolution – and Multifunctional OCT – Coherence Ranging and Imaging in the Human Eye over 35 Years \nAbstract \nIn the mid 1980s\, first applications of low coherence interferometry (LCI) to tissue metrology and analysis were reported. Starting from one-dimensional ocular biometry\, the technology has evolved into a high-speed\, 3-dimensional imaging technology\, now known as optical coherence tomography (OCT)\, with a multitude of functional extensions that has revolutionized ocular diagnostics. This talk illustrates the evolution of the technology over a third of a century\, as seen from a Viennese perspective. Starting with first axial eye length measurements by LCI\, a bridge is spanned to modern high-speed\, high-resolution\, and multifunctional OCT\, including some examples of current research in the OCT labs at Medical University of Vienna. \nBiography \nChristoph K. Hitzenberger is Professor of Medical Physics and Vice Chair of the Center for Medical Physics and Biomedical Engineering\, Medical University of Vienna\, and Editor-in-Chief of Biomedical Optics Express. He works in Biomedical Optics since 1987 and is one of the pioneers of low coherence ocular biometry and optical coherence tomography. Among his most important contributions to these fields were the introduction of the optical A-scan in 1990\, the first demonstration of Fourier domain OCT methods in 1995\, and pioneering work in polarization sensitive OCT since 2000. He is Fellow of OSA and of SPIE; his pioneering contributions to OCT were awarded with the Russ Prize of the US National Academy of Engineering in 2017 and with the Austrian Cross of Honour for Science and Art\, First Class. \n  \nREGISTER HERE \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/ocular-biometry/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/02/hitzenberger-headshot.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20201215T003000
DTEND;TZID=UTC:20201215T140000
DTSTAMP:20260513T160546
CREATED:20201202T023609Z
LAST-MODIFIED:20201212T220049Z
UID:29027-1607992200-1608040800@leadersinlight.com
SUMMARY:Bioengineering for COVID-19
DESCRIPTION:  \nBioengineering for COVID-19: Rapid Acceleration of Diagnostics (RADx) at Unprecedented Speed and Scale \nJoin Beall Applied Innovation and Beckman Laser Institute for a presentation from Bruce Tromberg\, director of the National Institute of Biomedical Imaging and Bioengineering. Bruce will discuss how the NIH launched the Rapid Acceleration of Diagnostics initiative in response to the COVID-19 crisis. \nThe virtual event is hosted by Richard Sudek\, executive director at Beall Applied Innovation and chief innovation officer at UCI\, and Tom Milner\, UCI professor\, Surgery and Biomedical Engineering and director at Beckman Laser Institute & Medical Clinic. \nSpeaker\nBruce Tromberg \nDirector @The National Institute of Biomedical Imaging and Bioengineering \nDr. Tromberg is the Director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) and leads NIBIB’s $500M Rapid Acceleration of Diagnostics (RADx Tech) innovation initiative for increasing SARS-COV-2 testing capacity and performance. Prior to joining NIH in January 2019\, he was a professor of Biomedical Engineering and Surgery at the University of California\, Irvine (UCI) where he served as director of the Beckman Laser Institute and Medical Clinic (BLIMC) and the Laser Microbeam and Medical Program (LAMMP)\, an NIH National Biomedical Technology Center. Dr. Tromberg specializes in the development of optics and photonics technologies for biomedical imaging and therapy. He has co-authored more than 450 publications and holds 21 patents in new technology development as well as bench-to-bedside clinical translation\, validation and commercialization of biomedical devices. \nREGISTER HERE
URL:https://leadersinlight.com/event/bioengineering-for-covid-19/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:Symposium
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/12/Bruce.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20201119T120000
DTEND;TZID=UTC:20201119T133000
DTSTAMP:20260513T160546
CREATED:20201117T045353Z
LAST-MODIFIED:20201120T071341Z
UID:28928-1605787200-1605792600@leadersinlight.com
SUMMARY:Muyinatu Bell.\, Ph.D.
DESCRIPTION:Assistant Professor & PULSE Lab Director – Johns Hopkins University \nDepartment of Electrical and Computer Engineering\nDepartment of Biomedical Engineering \nListening to the Sound of Light to Guide Surgeries \nAbstract\nPhotoacoustic imaging offers “x-ray vision” to see beyond tool tips and underneath tissue during surgical procedures\, yet no ionizing x-rays are required. Instead\, optical fibers and acoustic receivers enable photoacoustic sensing of major structures – like blood vessels and nerves – that are otherwise hidden from view. The entire process is initiated by delivering laser pulses through optical fibers to illuminate regions of interest\, causing an acoustic response that is detectable with ultrasound transducers. Beamforming is then implemented to create a photoacoustic image. In this talk\, I will highlight novel light delivery systems\, new spatial coherence beamforming theory\, deep learning alternatives to beamforming\, and robotic integration methods\, each pioneered by the Photoacoustic & Ultrasonic Systems Engineering (PULSE) Lab to enable an exciting new frontier of photoacoustic-guided surgery. This new paradigm has the potential to eliminate the occurrence of major complications (e.g.\, excessive bleeding\, paralysis\, accidental patient death) during a wide range of delicate surgeries and procedures\, including neurosurgery\, cardiac catheter-based interventions\, liver surgery\, spinal fusion surgery\, hysterectomies\, biopsies\, and teleoperative robotic surgeries.  \nBiography\nMuyinatu Bell is an Assistant Professor of Electrical and Computer Engineering\, Biomedical Engineering\, and Computer Science at Johns Hopkins University\, where she founded and directs the Photoacoustic and Ultrasonic Systems Engineering (PULSE) Lab. Dr. Bell earned a B.S. degree in Mechanical Engineering (biomedical engineering minor) from Massachusetts Institute of Technology (2006)\, received a Ph.D. degree in Biomedical Engineering from Duke University (2012)\, conducted research abroad as a Whitaker International Fellow at the Institute of Cancer Research and Royal Marsden Hospital in the United Kingdom (2009-2010)\, and completed a postdoctoral fellowship with the Engineering Research Center for Computer-Integrated Surgical Systems and Technology at Johns Hopkins University (2016). She is Associate Editor-in-Chief of IEEE Transactions on Ultrasonics\, Ferroelectrics\, and Frequency Control (T-UFFC)\, Associate Editor of IEEE Transactions on Medical Imaging\, and holds patents for short-lag spatial coherence beamforming and photoacoustic-guided surgery. She is a recipient of multiple awards and honors\, including MIT Technology Review’s Innovator Under 35 Award (2016)\, the NSF CAREER Award (2018)\, the NIH Trailblazer Award (2018)\, the Alfred P. Sloan Research Fellowship (2019)\, the ORAU Ralph E. Powe Jr. Faculty Enhancement Award (2019)\, and Maryland’s Outstanding Young Engineer Award (2019). She most recently received the inaugural IEEE UFFC Star Ambassador Lectureship Award (2020) from her IEEE society. \n  \nREGISTER HEREDr. Muyinatu Bell\, Ph.D. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/muyinatu-bell-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:LAMP Seminar
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/11/MuyinatuBell.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20201105T120000
DTEND;TZID=UTC:20201105T130000
DTSTAMP:20260513T160546
CREATED:20200916T002616Z
LAST-MODIFIED:20201013T002524Z
UID:27835-1604577600-1604581200@leadersinlight.com
SUMMARY:Stefan M. Cooper\, Jr.\, Ph.D.
DESCRIPTION:Assistant Professor of Chemistry- Alcorn State University \nDepartment of Chemistry and Physics \nAzo and Hydrazone Molecular Photoswitches’ Photoinduced Conformational Adjustability Exploited for a Light-Enabled Template for Site-Selective Arene C-H Bond Functionalization \nAbstract\nSite-Selectivity is highly desired for work in C-H bond functionalization as organic framework are typically saturated with C-H bonds of similar reactivity. Differentiating selectivity for a single desired C-H bond among a plethora of other similar C-H bonds is a daunting task. Template guided C-H bond functionalization has recently emerged as a solution to pursuits in site-selectivity. Key to this strategy is the strategic molecular shape of the template that affords advantageous intramolecular distances between a coordinated metallic catalyst (on the template) with a desired C-H bond (from a covalently attached substrate). We seek to contribute with the creation of a novel light-enabled template. This template anticipates affording opportunities in varied site-selectivity that is toggled by wavelength modulation. Our envisioned template is based on two initial molecular photoswitch framework: azo and hydrazone functionalities. Photoisomerization affords a “T-shape” conformation for azoheteroarenes that is exploited for remote site-selectivity. Equally\, photoisomerization of the hydrazone scaffold affords a key molecular rotation exploited for varied site-selectivity. The aforementioned work is proposed in for initiating an undergraduate research program in chemistry at a Historical Black University\, Alcorn State University. \nBiography\nStefan Malone Cooper\, Jr. obtained his B.S. in chemistry from the College of Charleston (Charleston\, SC) in 2007. There he worked\, as an undergraduate researcher\, on creating derivatives of the antibiotic\, Cytosporone E\, advised by Dr. Justin Wyatt. Later in 2015\, Stefan obtained a Ph.D. in Organic Chemistry advised by Dr. William E. Crowe. His dissertation was entitled “TRANS-POSITIONING” CARBONS WITHIN STRAINED CAGED BICYCLIC(S): ROM/RCM (RING-OPENING/RING-CLOSING METATHESIS AND DIECKMANN CONDESATION ROUTES TO A CIS-DECALIN INFRASTRUCTURE. Stefan complete a short stint as a postdoctoral researcher in the lab Dr. Herman Sintim in 2015\, at the University of Maryland and later was appointed in 2016 as a Path to Professoriate Fellow within Hampton’s University NSF Partnership for Research and Education in Material (PREM). Stefan was appointed as an assistant professor in the department of Chemistry and Physics at Alcorn State University\, Fall 2017. \n  \nREGISTER HERE: https://us02web.zoom.us/meeting/register/tZcudOyqrzMpG9dhBQnU8taUOUW-u6W_low9 \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/stefan-m-cooper-jr-phd/
LOCATION:Zoom Event\, CA\, United States
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/09/cooper-192x192-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20201015T120000
DTEND;TZID=UTC:20201015T130000
DTSTAMP:20260513T160546
CREATED:20201007T034433Z
LAST-MODIFIED:20201013T002714Z
UID:28827-1602763200-1602766800@leadersinlight.com
SUMMARY:Niklas Hedde\, Ph.D.
DESCRIPTION:University of California\, Irvine – Pharmaceutical Sciences\nLaboratory for Fluorescence Dynamics \nOptical Detection of Rare Space Time Events for Precision Medicine \nAbstract\nFinding low-abundance bioparticles and rare events in clinically relevant samples is an unresolved but very important issue in biomedicine\, specifically for rapid identification of infections and malignant tissues and the development of personalized cancer immunotherapeutics. Optical methods are minimally invasive and have the potential to identify targets and screen large samples within short periods of time with the capability to enable detailed analyses. \nHigh resolution quantification of rare interactions including immune cell interactions and circulating tumor cells invading healthy tissues could significantly advance the development of precision medicine treatments and personalized therapeutics. For this purpose\, we are developing an intelligent\, high throughput light sheet microscopy platform that can screen large complex structures in physiologically relevant 3D cell/tissue culture models and patient derived organoids. While nanoscale imaging with millisecond time resolution can map the dynamic spatial organization of biomolecules\, the same platform enables hyperspectral and fluorescence lifetime-based metabolic imaging. This technology has the potential to study treatment effectiveness in patient derived tissues/organoids to develop highly personalized therapeutics for cancer treatment. \nAt the same time\, rapid and accurate optical identification of viruses and bacteria in fluids and on surfaces could significantly advance diagnosis of infectious diseases\, detect contaminants in medical supplies\, identify circulating tumor cells\, and discover antibody-producing B cells and antigen-specific T cells\, to name a few. Existing biochemical or microfluidic methods take many hours or are not sensitive enough to detect highly dilute\, single targets. To address this issue\, we are developing a revolutionary 3D particle detection approach to find and isolate rare targets (1-100 per mL) directly from larger volumes of fluid (1-10 mL) within minutes. \nBiography\nPer Niklas Hedde\, Ph.D.\, is a researcher at the University of California\, Irvine where he develops camera-based fluorescence fluctuation spectroscopy techniques\, devices for the isolation of rare bioparticles from turbid media\, and optical methods for medical diagnosis and antibody discovery using non-linear excitation with lifetime and hyperspectral detection. He studied physics at the University of Ulm\, Germany\, with a master thesis project on ultrafast analysis of super-resolution microscopy data. He completed his Ph.D. in physics at the Karlsruhe Institute of Technology where he built an instrument for super-resolved image correlation spectroscopy to study the dynamics of cell membrane receptors and developed localization microscopy techniques to image protein mutations and receptor interactions related to heart disease and allergy. For his thesis work he received the Karlsruhe Institute of Technology Award for Outstanding Doctoral Research Work in the Area of Applied Life Sciences 2014 and the Gregorio Weber International Prize 2014. He then accepted a postdoctoral position at the Laboratory for Fluorescence Dynamics at UC Irvine to broaden his skills including fluorescence lifetime\, spectral and polarization imaging. During this time\, he also visited and collaborated with the Karolinska Institute in Stockholm\, Sweden to learn about natural killer cells\, their value for cancer immune therapy and to establish fluctuation spectroscopy methods at the KI Department of Microbiology\, Tumor and Cell Biology. So far\, he has published 30 peer-reviewed journal articles and is member of the Biophysical Society (US and Germany)\, the American Association for Cancer Research\, and the UC Irvine Center for Complex Biological Systems. Most recently\, he received an R21 award from NIH for the development of “Fluctuation Spectroscopy with Light Sheet Microscopy”. \n  \nREGISTER HERE: https://us02web.zoom.us/meeting/register/tZwudeqhrjwtHNYaqYT7RSFNQKVOZJZ5uY9Z \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/niklas-hedde-ph-d/
LOCATION:Zoom Event\, CA\, United States
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/09/pnhedde.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200623T080000
DTEND;TZID=UTC:20200623T090000
DTSTAMP:20260513T160546
CREATED:20200623T050228Z
LAST-MODIFIED:20200623T051025Z
UID:28447-1592899200-1592902800@leadersinlight.com
SUMMARY:VBF Facebook Live Discussion
DESCRIPTION:Topic: Port Wine stains & Hemangiomas during COVID-19 \nFaceBook Link: VascularBirthmarksFoundation\n\n\n\nThis is a free event.
URL:https://leadersinlight.com/event/vbf-facebook-live-discussion/
LOCATION:FaceBook Live\, CA\, United States
CATEGORIES:Symposium
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/06/VBF-JSNELSON-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200508T080000
DTEND;TZID=UTC:20200508T170000
DTSTAMP:20260513T160546
CREATED:20200501T234125Z
LAST-MODIFIED:20200509T034221Z
UID:28095-1588924800-1588957200@leadersinlight.com
SUMMARY:Brain & Kidney Symposium
DESCRIPTION:  \nThe Department of Veterans Affairs\, Employee Education System\, 10P11 – Specialty Care Services & Neurology jointly provided with the UCI School of Medicine Presents: \n\n\nThe 2020 Brain & Kidney Symposium\n\n\nPlease join us for the world’s first all-day virtual International Conference highlighting the interface between neuroscience\, neurology\, and nephrology. The multidisciplinary panel of speakers and moderators includes experts from the fields of neurology\, nephrology\, pathology\, and psychiatry.  Up to 7.0 CME credits will be available. \n\n\n\nLecture Topics include: \n\nAnatomical and Physiological Considerations for the Brain-Kidney Axis\, including the Basics of Chronic Kidney Disease (CKD)\nCerebral Blood Flow\, Neuropathology\, and  Microvascular Disease in CKD\nCKD and Dementia\, Epilepsy\, Movement and Sleep Disorders\, and in the Neuro-ICU\nStroke Epidemiology\, Prevention\, and Treatment in CKD\nNeuroimaging\, Dietary Issues\, and Fabry Disease in the Brain-Kidney Axis\n\nThis is a free event.\nZoom link: https://zoom.us/j/401668288\nPASSWORD:  503699\nAttendees must Register to receive post-event link to request CME.\n\n  \nFor more information\, contact Kristine Fuentebella at kfuenteb@uci.edu or 714-456-5142.
URL:https://leadersinlight.com/event/brain-and-kidney-symposium/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:Symposium
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2020/05/Brain-Kidney-Symposium.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200227T120000
DTEND;TZID=UTC:20200227T130000
DTSTAMP:20260513T160546
CREATED:20200212T024829Z
LAST-MODIFIED:20200212T025402Z
UID:27789-1582804800-1582808400@leadersinlight.com
SUMMARY:Dr. Vivek Jay Srinivasan
DESCRIPTION:Associate professor of Biomedical Engineering and Ophthalmology at the University of California\, Davis \nHuman Brain Interferometers for Better Blood Flow Monitoring \nAbstract \nSteady cerebral blood flow (CBF) is needed for normal brain function\, but continuous monitoring of CBF in humans is currently challenging.  Here\, by leveraging a low-cost sensor technology\, we introduce a class of novel near-infrared optical devices that monitor CBF continuously and non-invasively in adult humans.  We achieve this by replacing expensive single photon counting detectors\, currently used for optical CBF monitors\, with complementary metal–oxide–semiconductor (CMOS) arrays. We maintain performance by employing an additional optical “trick” known as interferometry\, which transforms each CMOS pixel into a sensitive detector for fluctuations of coherent light that probes blood flow in the brain.   Our method is called interferometric Diffusing Wave Spectroscopy (iDWS).  Since CMOS camera pixels are cheap and numerous\, iDWS both improves the performance and reduces the cost of optical CBF monitoring\, enabling record brain-to-scalp sensitivity. By liberating CBF monitoring from photon counting\, iDWS enables measuring CBF continuously in a new environments. In this talk we describe technical advantages of iDWS relative to conventional methods\, and broadly envisage how interferometry can help to advance the field of diffuse optics. \nBiography \nVivek Srinivasan is Associate Professor of Biomedical Engineering and Ophthalmology and Chancellor’s Fellow at UC Davis. His group develops new light-based technologies for in vivo imaging and sensing of the brain and eye.  Starting with a firm grounding in neurophysiology and biomedical engineering\, his group employ ideas novel photonic technologies and approaches to accomplish this goal. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Bernard Choi
URL:https://leadersinlight.com/event/vivek-srinivasan/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/02/Vivek.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200213T123000
DTEND;TZID=UTC:20200213T133000
DTSTAMP:20260513T160546
CREATED:20200206T024504Z
LAST-MODIFIED:20200206T024504Z
UID:27752-1581597000-1581600600@leadersinlight.com
SUMMARY:The Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques
DESCRIPTION:Woonggyu Jung\, Ph. D.  \nUlsan National Institute of Science and Technology\, Korea \nThe Potential of Digital Histopathology Using Label-Free Optical Imaging Techniques\n  \nAbstract \nThe histological optical imaging is a gold standard method to observe the biological tissues\, which follows routine process such as dissection\, embedding\, sectioning\, staining\, visualization and interpretation of specimens. This technique has a long history of development\, and is used ubiquitously in pathology\, despite being highly time and labour-intensive. Advanced optical imaging techniques developed over the last decade have enabled to provide high sensitivity\, high resolution and non-invasive biological information. However\, acquiring high throughput\, large volume tissue anatomy remains a difficult challenge due to the effect of light scattering\, which limits the penetration imaging depth and lateral resolution. Recently\, various optical imaging methods have been introduced to create volumetric anatomy data of ex vivo tissues using physical tissue sectioning or optical clearing. Even though these new approaches present the distinguished volumetric anatomy in various scales\, they are still not suitable for use in statistical studies with multiple tissues and organs. Here\, we introduce novel label-free and multi-scale imaging modality based on serial optical coherence microscopy (OCM). OCM is a potential technique to build volumetric anatomy of mouse tissues or organs due to its simplicity\, efficiency\, robustness\, and high-throughput capabilities. This presentation covers the latest work of large-scale brain and kidney imaging using OCM and its potential in bio-applications. Specifically\, the talk will highlight other label-free optical imaging modalities including wide-field quantitative phase microscopy and optical projection tomography toward to multi-scale histopathology. \nBiography \nWoonggyu Jung received his Ph. D. in 2008 from the Department of Biomedical Engineering at the University of California\, Irvine. From 2001 to 2008\, he worked at the Beckman Laser Institute and Medical Clinic at UC Irvine. He also worked at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign since January 2009. He has joined the faculty of UNIST in 2012\, and currently works as an associate professor of Department of Biomedical Engineering. He is also co-founder and CTO of start-up company\, Conecson which is focused on the futuristic business regarding to mobile-based medical devices. Dr. Jung has a strong research background in optical imaging technologies including optical coherence tomography (OCT)\, quantitative phase microscope (QPM)\, and miniaturized optical imaging probes. His research interest is to develop new optical technologies that address challenges in clinical medicine\, basic biological research and neuroscience. In previous work\, he developed a successful optical platform for in vivo translational research\, and has published more than 60 peer-reviewed journal papers in the field of biophotoics. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Zhongping Chen
URL:https://leadersinlight.com/event/woonggyu-jung/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/02/Woonggyu-Jung.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200210T120000
DTEND;TZID=UTC:20200210T130000
DTSTAMP:20260513T160546
CREATED:20200111T051746Z
LAST-MODIFIED:20200111T073656Z
UID:27661-1581336000-1581339600@leadersinlight.com
SUMMARY:Professor Alfred Vogel
DESCRIPTION:Institute of Biomedical Optics\, University of Lüebeck\, Germany \nFree-electron-mediated modifications of biomolecules: from photodamage in nonlinear microscopy to intentional photomodification of cells and tissues \n\nAbstract\nFemtosecond laser-induced plasma generation is used surgically and may also cause photodamage in nonlinear microscopy. The irradiance threshold at which transient vapor bubbles in water are produced by single pulses is 20 times higher than the irradiance used for microscopy. However\, photodamage in multiphoton microscopy already starts\, when the irradiance is raised 1.5 times above the value used for autofluorescence imaging. The huge realm of low-density plasma effects between multi-pulse nonlinear imaging and single-pulse surgical regime is little explored. We provide a systematic overview over irradiance and radiant exposure dependence of laser effects in this regime. Surgery by single-pulses relies on the disruptive effect of nm to µm sized transient cavitation bubbles. The threshold is here determined by a critical temperature above which a phase transition occurs. Series of low-energy fs pulses induce free-electron mediated modifications and finally disintegration of biomolecules. Bubble here contain non-condensable gas rather than water vapor. The underlying process is a nonlinear chemical rate process\, and threshold characteristics differ fundamentally from the single-pulse threshold. Below bubble threshold\, photomodifications can be utilized to create corneal refractive changes suitable for non-ablative treatment of myopia and hyperopia. Photodamage in multiphoton microscopy was explored for various cell types and tissues using physical indicators enabling real-time-monitoring of the damage kinetics. We characterize the transition from unchanged tissue (emitting autofluorescence) to slightly changed tissue (hyperfluorescence)\, drastically changed tissue (plasma luminescence) and finally molecular disintegration leading to gas bubble formation. By plotting the threshold values in (irradiance\, radiant exposure) space\, we can clearly identify a “safe” region for nonlinear microscopy and separate it from regions for different types of photomodification.  \nBiography\nProf.  Alfred Vogel is Team Leader and former Director of the Institute of Biomedical Optics (BMO)\, University of Luebeck\, Germany. Hereceived the Ph.D. degree in Physics from University Goettingen in 1987\, and the degree of Habilitated Doctor of Physics from the University of Luebeck\, Germany\, in 1999. Since 2010 he is also Adjunct Professor of Xiʼan Jiaotong University\, PR China. Dr. Vogel is fellow of the Optical Society (OSA) and of SPIE. He has published over 90 peer-reviewed jounral articles and 51 proceedings papers. His published work has received over 12\,000 citations with a h-index of 47. He holds 11 patents.\n          Dr. Vogel has made major experimental and theoretical contributions to the field of pulsed laser interactions with molecules\, cells and biological tissues.  He developed comprehensive theoretical frameworks for pulsed laser tissue interactions ranging from photochemical changes to ablation\, and for controlled nonlinear energy deposition in transparent dielectrics.\nHe invented new technologies for imaging and characterization of plasmas\, shock waves\, cavitation bubbles\, and ablation plume dynamics. His research encompasses surface ablation through linear absorption of ultraviolet and infrared laser pulses\, ablation processes in a liquid environment such as in blood vessels or joints\, as well as precise plasma-mediated ablation\, surgery\, and molecular modificationswithin nominally transparent materials such as ocular tissues and cells.  His work in these areas hasled to innovative strategies for improving cellular micro/nano surgery\, intraocular surgery\,and refractive surgery.\n          Dr. Vogel served on the editorial board for the Journal of Biomedical Optics (2002-2019)\, served as associate editor of Optics Express (2006-2009)\, and as advisory editor of Biomedical Optics Express (2010-2019). \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova.\nSponsored by the Berns Family Laser and Microbeam Program
URL:https://leadersinlight.com/event/alfred-vogel/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/01/Vogel-Head-Shot.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20200117T120000
DTEND;TZID=UTC:20200117T130000
DTSTAMP:20260513T160546
CREATED:20200111T082429Z
LAST-MODIFIED:20200111T082429Z
UID:27674-1579262400-1579266000@leadersinlight.com
SUMMARY:Dr. James V. Jester
DESCRIPTION:Endowed Research Chair and Professor of Ophthalmology and Biomedical Engineering\nUniversity of California\, Irvine \nNon Linear Optical Corneal Collagen Crosslinking (NLO CXL) for Treatment of Refractive Errors\nAbstract\nCorneal collagen crosslinking (CXL) using ultraviolet light (UVA) photoactivation of riboflavin leads to corneal mechanical stiffening that shows significant therapeutic benefits for patients with Keratoconus\, and also corneal flattening\, which could be helpful for the correction of minor refractive errors. However\, there are several drawbacks to UVA CXL including\, 1) difficulty controlling area and depth of corneal CXL\, and 2) removal of the corneal epithelium to imbibe riboflavin into the stroma.  The former limits the ability of UVA CXL to customize corneal stiffening to treat refractive errors\, while the later leads to post-operative pain\, delayed visual recovery time\, and increased risk of infection. In this talk I will present our work on developing a non linear optical (NLO) approach to corneal CXL that addresses these major limitations.  First\, we have developed a delivery device that focus amplified femtosecond laser pulses at any depth or position within the corneal stroma to precisely activate riboflavin using two photon excitation. Secondly\, we have used laser induced optical breakdown to machine the corneal epithelium and form microchannels that are 2-3 micron in diameter and 25 micron in length to significantly enhance to penetration of riboflavin through the corneal epithelium. We have also performed live rabbit eye studies showing that these advances protect the corneal epithelium from damage\, and can produce 1-2 diopters of central corneal flattening. \nBiography\nDr. Jester is currently the Jack H. Skirball Endowed Research Chair and Professor of Ophthalmology and Biomedical Engineering at the University of California\, Irvine.  Dr. Jester’s trained as an Experimental Ocular Pathologist whose research has focused on the cellular and molecular biology of the cornea and ocular surface.  Dr. Jester has extensive experience using multi-dimensional imaging modalities to evaluate corneal structure and function.  His current research includes the application of non-linear optical microscopy to image second harmonic generated signals from collagen to study the collagen structural organization of the cornea.   \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova.\nSponsored by the Berns Family LAser and Microbeam Program and the Department of Ophthalmology
URL:https://leadersinlight.com/event/james-v-jester/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/01/James-Jester.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20191022T120000
DTEND;TZID=UTC:20191022T130000
DTSTAMP:20260513T160546
CREATED:20191018T221509Z
LAST-MODIFIED:20191018T221617Z
UID:27380-1571745600-1571749200@leadersinlight.com
SUMMARY:Professor Peter Török
DESCRIPTION:Nanyang Technological University\, Singapore \nBrillouin Microscopy and Endoscopy \nAbstract\nBrillouin imaging can extract viscoelastic properties with micron-level resolution in a label-free\, non-invasive way. The conventional bulk-optics based Brillouin system has already been applied to various biological samples. While the utility of Brillouin imaging has been demonstrated\, the intrinsically weak scattering process means that recent work in instrumentation has aimed to maximize the efficiency of existing technology\, as well as making it more compact and portable. For more systematic optimization strategies\, the theoretical parameters to evaluate the performance of arbitrary Brillouin spectrometers have been proposed for the first time. This enables the optimization of Brillouin systems in general. In this talk I present the latest developments in Brillouin instrumentation. This also includes software-based reconstruction techniques to enhance the SNR of the system. These methods are more attractive for their wider applicability and have been found to be capable of extracting useful Brillouin shift value with low SNR in simulation and experiment.\nOne application of Brillouin imaging in particular – the in vivo assessment of arterial stiffness\, i.e. Brillouin Endoscopy\, is seen to have much potential as a diagnosis tool for cardiovascular diseases\, despite some challenges. We thus present recent effort on the optimization and miniaturization of the existing technology into a flexible\, fiber-based device has provided some solutions. The main consideration for creating a fiber-based Brillouin system is the strong background generated by the fiber. So far\, a proof-of-concept device that does not require filtering has been constructed and the measurements in typical liquids have been achieved. Alternatively\, a more efficient\, single-path set-up is also discussed as it may yield higher throughput.\nRecently\, the meaning of Brillouin measurements and its correlation to stiffness has been further investigated. It has been shown that the influence of water content in the mechanical behavior of hydrated samples may dominate the Brillouin shift value. The addition of a Raman mode to measure this relative change in hydration may help to yield more accurate mechanical measurements. The correlative study of hydrogels was thus demonstrated as to show that inelastic spectroscopy in tandem is viable.\nFinally\, to maximize the information from the hyperspectral data that is obtained from BI\, the power of some multivariate analysis algorithms is discussed as alternatives for future work\, the application in live cell imaging is highlighted. \nBiography \nPeter Török graduated with an MSc in Electrical Engineering (Microelectronics) from the Technical University of Budapest\, Hungary and a DPhil in Physical Sciences from the University of Oxford. After postdoctoral positions at the Universities of Cambridge and Oxford\, he was appointed Lecturer in Photonics at Imperial College London in 2002\, where he was promoted Reader in Photonics and Professor of Optical Physics in 2005 and 2009\, respectively. In 2018\, Peter moved to NTU where he has joint appointments with the Division of Physics and Applied Physics\, School of Physical and Mathematical Sciences\, Lee Kong Chian School of Medicine and the Singapore Centre for Environmental Life Sciences Engineering (SCLESE)\, where he is Director of Imaging. \nPeter has rich experience in designing and building precision optical system also including instruments that have been sold to word leading companies. He has spent most of his working life in optical and confocal microscopy\, polarized light imaging\, optical data storage\, electromagnetic imaging theory\, compressive/single pixel imaging\, reconfigurable optics and various metrology applications\, information theoretic aspects of imaging and spectroscopic imaging\, including Raman and Brillouin modalities. At NTU his group mostly concentrates on highly interdisciplinary applications of optics working in collaboration with colleagues in life- and biomedical sciences. \nFor more information or to schedule a meeting with the speaker\, please contact Hanna Kim.
URL:https://leadersinlight.com/event/peter-torok/
LOCATION:BLI Library
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2019/10/Peter-Torok.jpg
END:VEVENT
END:VCALENDAR