BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Beckman Laser Institute - ECPv6.16.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Beckman Laser Institute X-ORIGINAL-URL:https://leadersinlight.com X-WR-CALDESC:Events for Beckman Laser Institute REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20210314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20211107T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20220313T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20221106T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20230312T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20231105T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20240310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20241103T090000 END:STANDARD END:VTIMEZONE BEGIN:VTIMEZONE TZID:UTC BEGIN:STANDARD TZOFFSETFROM:+0000 TZOFFSETTO:+0000 TZNAME:UTC DTSTART:20190101T000000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230420T090000 DTEND;TZID=America/Los_Angeles:20230420T100000 DTSTAMP:20260513T150625 CREATED:20230413T235332Z LAST-MODIFIED:20250325T201003Z UID:31266-1681981200-1681984800@leadersinlight.com SUMMARY:Martin Lavery\, Ph.D. DESCRIPTION:Environmental and Fiber Sensing with Structured Light \nAbstract \nStructured light is being widely used to revolutionize the technologies used in optical trapping\, microscopy\, astronomical metrology\, optical communication\, quantum information systems\, and many others. One defines an optical wavefront that has been spatially shaped in its phase\, polarisation or intensity as structured light. Prof. Lavery will present an introduction to the research field and an overview of their work in the Structured Photonics Research Group\, at the University of Glasgow\, in the creation\, detection\, and application of shaped optical beams for a range of sensing applications. He will discuss the development of technologies to generate and measure structured light\, including reconfigurable platforms based on silicon Photonic Integrated Circuits (PICs). \n Further\, he will present their recent advances in utilising structured light for sensing in complex optical environments such as underwater scattering\, atmospheric turbulence\, and multimode optical fibers. They have developed approaches that use spatial mode sensitive receivers to extract features buried in aberrated optical fields that can increase the accuracy of the measurement of particulates in submersed channels\, measure wind speed and temperature from the air\, and sense changes in the shape of optical fibers. These sensors could be used for environmental pollution sensing in water\, failure monitoring in mechanical systems\, and sub-km weather monitoring critical for developing accurate climate models. \nBiography \nProfessor Martin Lavery is a Full Professor in Optics and is the leader of the Structured Photonics Research Group at the James Watt School of Engineering at the University of Glasgow (UofG). Prof. Lavery has a portfolio\nof over $6 million in independent research funding as Principal Investigator (PI) and is leading the H2020 Future and Emerging Technologies (FET-Open) consortium project named SuperPixels\, each of which have an array of international partners from both industry and academia. He has held the prestigious Royal Academy of\nEngineering (RAEng) Research Fellowship from 2014-2019. Prof. Lavery’s H-index is 41 with over 60 publications in peer-reviewed journals and over 80 conference\nmanuscripts that have collectively attracted over 11\,000 citations (Google Scholar\, Dec 2022). He has been awarded the 2013 Scopus Young Scientist of the Year for Physical Sciences\, the 2018 Mobile World Scholar Gold Medal\, and the 2019 Royal Society of Edinburgh Sir Thomas Makdougall Brisbane Medal for accomplishments in\noptical communication and sensing. \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/martin-lavery-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2023 Virtual Seminar Series ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2023/04/image.1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230330T090000 DTEND;TZID=America/Los_Angeles:20230330T100000 DTSTAMP:20260513T150625 CREATED:20230328T165357Z LAST-MODIFIED:20230328T165742Z UID:31224-1680166800-1680170400@leadersinlight.com SUMMARY:Daniel Razansky\, Ph.D. DESCRIPTION:Cardio-oncology; Advanced optoacoustic imaging methods for biomedical research and clinical diagnostics \nAbstract \nOptoacoustic imaging has achieved remarkable progress over the last decade\, benefiting from coordinated developments in optical and ultrasound technology\, probe chemistry\, and imaging theory. The technique is increasingly attracting attention of the biomedical research community due to its excellent spatial and temporal resolution\, centimeter scale penetration into living tissues\, versatile endogenous and exogenous optical absorption contrast. State-of-the-art implementations of multispectral optoacoustic tomography are based on multi-wavelength excitation of tissues to visualize specific molecules within opaque tissues. As a result\, optoacoustics can noninvasively deliver structural\, functional\, metabolic\, and molecular information from living tissues. \nThe talk covers advances in optoacoustic microscopy and tomography instrumentation\, reconstruction algorithms for ultrafast imaging\, as well as synergistic combinations with fluorescence\, magnetic resonance and ultrasound methods. Efforts are underway to explore potential of the technique in studying multi-scale dynamics of the brain and heart\, monitoring of therapies\, targeted molecular imaging applications and clinical diagnostics of patients in a number of indications\, such as breast and skin lesions\, inflammatory diseases and cardiovascular diagnostics. \nBiography \nProfessor Daniel Razansky holds the Chair of Biomedical Imaging with double appointments at the Faculty of Medicine\, University of Zurich and Department of Information Technologies and Electrical Engineering\, ETH Zurich in Switzerland\, where he also serves as Director of the joint Preclinical Imaging Center. \nHe earned degrees in Biomedical and Electrical Engineering from the Technion – Israel Institute of Technology and conducted postdoctoral research at the Harvard Medical School. Previously\, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich in Germany. \nThe Razansky Lab pioneered a number of bio-imaging technologies that were successfully commercialized and put into use in research labs and clinical facilities across the globe\, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). His research has been recognized by the German Innovation Prize and multiple awards from the ERC\, NIH\, SNF\, DFG and HFSP. He is also Fellow of the IEEE\, SPIE and Optica Societies. \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/daniel-razansky-phd/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2023 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/updated.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230316T120000 DTEND;TZID=America/Los_Angeles:20230316T130000 DTSTAMP:20260513T150626 CREATED:20230314T184923Z LAST-MODIFIED:20230314T184923Z UID:31214-1678968000-1678971600@leadersinlight.com SUMMARY:Mehmet Cilingiroglu\, MD\, FSCAI\, FACC\, FESC DESCRIPTION:Cardio-oncology; Cardiovascular diseases in cancer patients \nAbstract \nWith more advances in cancer therapy\, more patients are alive as cancer survivors than a decade ago.\nHowever\, cardiovascular disease is the number one reason for mortality in these cancer free patients.\nBeside the conventional risk factors for cardiovascular diseases\, radiation and chemotherapy and\ncancer specific immunotherapy contributes to increased risk. We will discuss the details of\ncardiovascular disease etiologies and treatment options in this specific patient population. \nBiography \nDr. Cilingiroglu is a well-established interventional cardiologist and structural heart interventionalist.\nHe has academic affiliations with several different universities in the USA as well as in EU for various\nresearch and educational collaborations. Beside providing excellent clinical cardiovascular care\, over\nthe last two decades he has been involved and lead many different investigator initiated and novel\ndevice development studies. Have been collaborating with Professor Milner and his team for many\nyears. \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/mehmet-cilingiroglu/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/Mehmet.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230207T120000 DTEND;TZID=America/Los_Angeles:20230207T130000 DTSTAMP:20260513T150626 CREATED:20230314T184214Z LAST-MODIFIED:20230314T184214Z UID:31208-1675771200-1675774800@leadersinlight.com SUMMARY:Jiawen Li\, Ph.D. DESCRIPTION:Ultrathin 3D-printed Imaging Devices \nAbstract \nPreclinical studies and clinical diagnostics increasingly rely on optical techniques to visualize internal\norgans. Miniaturised catheters or endoscopes are necessary for imaging small and/or delicate\narteries. However\, current lens fabrication methods limit the performance of these ultrathin devices\,\nresulting in a poor combination of resolution\, depth of focus and multimodal imaging capability.\nThis talk will introduce her latest research to address these combined challenges. In particular\, she\nhas utilized 3D micro-printing technology to fabricate lenses\, with a diameter of less than 350 μm\,\ndirectly onto an optical fiber to achieve freeform designs for 1) aberration-corrected optical coherence\ntomography (OCT)\, 2) Bessel beam OCT\, and 3) highly-sensitive multimodal fluorescence+OCT\nimaging in vivo. \nBiography \nDr. Jiawen Li is a Fellow of L’Oréal-UNESCO\, National Heart Foundation and NHMRC\, and a Senior\nLecturer at the School of Electrical and Electronic Engineering\, the University of Adelaide. She received\nher Bachelor’s degree in Optical Engineering from Zhejiang University (China) in 2010\, and her PhD\ndegree in Biomedical Engineering from the University of California\, Irvine (USA) in 2015.\nSince finishing her PhD\, Dr. Li has secured >$2 million research funding as the lead chief/principal\ninvestigator and won numerous prestigious awards/honours (including national Superstar of STEM\,\nAustralian and New Zealand Optical Society Geoff Opat Early Career Researcher Prize\, Heart\nFoundation Paul Korner Innovation Award\, Young Tall Poppy Science Award\, etc.). Dr Li’s research\nfocuses on multimodal imaging\, ultrathin endoscopes\, optical sensing\, 3D micro-printing\, and optical\ncoherence tomography. \n\n  URL:https://leadersinlight.com/event/jiawen-li-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/Jiawen2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230126T120000 DTEND;TZID=America/Los_Angeles:20230126T130000 DTSTAMP:20260513T150626 CREATED:20230314T183414Z LAST-MODIFIED:20230314T183414Z UID:31203-1674734400-1674738000@leadersinlight.com SUMMARY:Yun Jing\, PhD DESCRIPTION:Numerical Modeling of Medical Ultrasound \nAbstract \nIn the last two decades\, we have witnessed substantial development in high intensity focused ultrasound (HIFU) for treating a\nbroad spectrum of diseases and medical conditions. As a non invasive surgical modality that can reach deep tissue\, HIFU has\nthe potential to revolutionize therapy. Although there are many numerical models available\, none can currently achieve both\nefficient and sufficiently accurate simulations for acoustic wave propagation in large scale\, heterogeneous biological media.\nExisting numerical models face two enduring dilemmas: they are either very efficient but not accurate due to invalid\napproximations\, or they are very accurate but computationally time consuming and therefore impractical in many cases. I will\ndiscuss our effort throughout the past 10 years in developing new numerical models for HIFU\, that aims to establish a\nbalance between accuracy and computational efficiency. I will focus on both the theoretical development and the practical\napplications of the numerical algorithm. I will also introduce our NIH funded project that aims to develop an open source\ntoolbox for modeling medical ultrasound (https://m-sound.github.io/mSOUND/home). \nBiography \nYun Jing\, Ph.D. was a research fellow at Brigham and Women’s Hospital\, and an assistant professor and associate professor\nat North Carolina State University\, prior to joining the Graduate Program in Acoustics at Penn State University in 2020.\nDr. Jing has published over 85 peer reviewed scientific manuscripts. Dr. Jing is fellow of ASA\, a senior member of IEEE\,\nand an associate editor of the Journal of the Acoustical Society of America and Frontiers in Materials. He has received\nnumerous awards such as the 2018 R. Bruce Lindsay Award from the Acoustical Society of America\, the 2018 IEEE\nUltrasonics Early Career Investigator award\, 2018 MIT Technology Review Innovator under 35 China award\, and the\nIEEE UFFC Star Ambassador Lectureship Award. Dr. Jing earned his B.S. in acoustics from Nanjing University\, China\,\nM.S.\, and Ph.D. in architectural acoustics from Rensselaer Polytechnic Institute. \n  URL:https://leadersinlight.com/event/yun-jing-phd/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/jing.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230112T120000 DTEND;TZID=America/Los_Angeles:20230112T130000 DTSTAMP:20260513T150626 CREATED:20230109T213645Z LAST-MODIFIED:20230109T213950Z UID:31131-1673524800-1673528400@leadersinlight.com SUMMARY:Lilit Garibyan\, MD\, PhD\, FAAD DESCRIPTION:A Leadership Toolbox for Operationalizing Innovation at Your Institution \nAbstract \nIn today’s challenging healthcare environment\, the importance of innovation has never been greater. Every healthcare institution anduniversity strive to be innovative\, but successful innovative cultures and programs are difficult to create and sustain especially in the busy and fast-paced healthcare settings. Creating an innovative culture requires having a structured process and framework that educates\, trains and rewards individuals who engage in innovation. \nThe “Magic Wand Initiative” was created at Massachusetts General Hospital to empowers and engages healthcare professional in problembased innovation. It is designed to bring innovation directly to clinicians\, reduce the barriers to engagement and provide necessary resourcesm for clinicial and research faculty to work collaboratively to solve unmet needs and generate outcomes. Over the last several years I have lectured about this revolutionary and impactful national and international curriculum called the “Magic Wand Initiative and Virtual Magic Wand program” http://www.magicwandinitiative.org/ to teach leaders and clinicians how to leverage innovation for outcomes. In this talk we will aim to:\n• Describe the importance of innovation in healthcare\n• Identify common barriers to innovation\n• Develop strategies that individuals and institutions can use to implement innovation \n  \nBiography \nDr. Lilit Garibyan MD\, PhD is a physician-scientist at Wellman Center for Photomedicine\, board certified dermatologist and faculty member at Harvard Medical School Department of Dermatology. She is listed as an inventor on 15 pending and granted patents in fields of medical devices\, immunology\, dermatology\, cardiology\, and medical innovation. Her research focuses on innovative biomedical translational discoveries aimed at identifying unmet medical needs and working with multidisciplinary teams to develop novel treatments. She used this same approach to pioneer injectable cooling devices for aesthetic and medical application since 2012. Several of her inventions have been licensed and led to venture-backed startup companies. She is the co-founder of two startup biotech companies which have resulted from her research discoveries. She serves on several scientific advisory boards for startup companies. \nDr. Garibyan is the co-founder and the Director of the “Magic Wand Initiative” and the Virtual Magic Wand programs\, which teach the process of innovation. These internationally recognized programs empower\, engage\, and teach professionals on how to identify unmet needs and collaborate to identify and implement solutions to problems. \nAs a humanitarian\, Dr. Garibyan has pioneered and established sustainable\, medical laser clinics in Armenia for effective treatments of scars and vascular anomalies. Her team has taken several lasers to Armenia and has trained Armenian physicians on the use of laser technology to treat life altering skin diseases. Dr. Garibyan recently founded and serves as the President of a nonprofit organization called “Face of Angel” to continue the mission of this humanitarian work. \nDr. Garibyan received her B.S. summa cum laude from University of California Los Angeles\, her M.D. from Harvard Medical School and her\nPh.D. from Harvard University in Experimental Pathology/Immunology. \n  \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/lilit-garibyan-md-phd-faad/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/01/Lilit-Garibyan.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20221027T120000 DTEND;TZID=America/Los_Angeles:20221027T130000 DTSTAMP:20260513T150626 CREATED:20230109T214453Z LAST-MODIFIED:20230109T214453Z UID:31140-1666872000-1666875600@leadersinlight.com SUMMARY:Gultekin Gulsen\, Ph.D. DESCRIPTION:True multi-modality optical molecular imaging – where both modalities interact and work in harmony. \nAbstract \nThe main goal of the molecular imaging community has been achieving higher resolution and better quantitative accuracy.\nFor nearly two decades\, I have been spending effort for the same purpose\, mainly integrating optical imaging with anatomic\nimaging modalities such as MRI and X-ray CT. For example\, my team has developed a gantry-based combined X-ray CT and\nFluorescence Tomography system for small animal imaging. This system is unique in that both X-ray CT and optical imaging\nsystems are on the same gantry rotating around the animal and capable of revealing cross-sectional background optical\nabsorption map and anatomic images that can be used to obtain quantitatively correct fluorophore concentration maps.\nAnother hybrid system that is being developed in my lab is a combined MRI-Diffuse Optical Tomography scanner for small\nanimal imaging in both absorbance & fluorescence modes. \nIn all of these applications\, optical and anatomic imaging modalities worked in harmony but independent from each other.\nRecently\, we have focused on development of novel multimodality techniques\, in which optical and anatomic imaging\nmodalities work in harmony and interact with each other to provide images that cannot be obtained solely with one or the\nother. This talk will highlight two of these true-multimodality imaging techniques developed in our lab: Photo-magnetic\nImaging (PMI) and Temperature Modulated Fluorescence Tomography (TM-FT)\, where optical tomography is achieved at MRI\nand Focused Ultrasound resolution\, respectively while preserving its superior sensitivity. \n  \nBiography \nDr. Gulsen is an Associate Professor in the Departments of Radiological Sciences\, Biomedical Engineering\, Physics & Astronomy\, and Electrical Engineering & Computer Science at the University of California\, Irvine. He has been serving as the Director of In vivo Functional Onco-Imaging Shared Resource of the UCI Cancer Center for more than15 years. His research involves development of both cutting-edge instrumentation and novel mathematical algorithms for multi-modality imaging techniques. Although most of those techniques have been related to optical molecular tomography\, his team was also involved in development of the the world’s first MR compatible SPECT small animal imaging and Positron Emission\nMammography systems. \n  \n  URL:https://leadersinlight.com/event/gultekin-gulsen-phd/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/01/Gultekin-UCI-best-pic.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20220929T120000 DTEND;TZID=America/Los_Angeles:20220929T130000 DTSTAMP:20260513T150626 CREATED:20220624T202639Z LAST-MODIFIED:20220719T172026Z UID:30667-1664452800-1664456400@leadersinlight.com SUMMARY:Errol Arkilic\, Ph. D. DESCRIPTION:Commercialization and searching for a business model: why is spinning technology out of a lab so challenging? \nAbstract \nIn this talk\, we will explore the four critical challenges of getting technology out of a lab. Dr. Arkilic\, Chief Innovation Officer of UCI has spent his entire career in supporting getting technology out of Academic labs. He has been founder StrataGent Life Sciences\, Inc.\, lead program manager for the NSF SBIR program\, founder of the NSF I-Corps program and founder of M34 Capital\, a venture capital firm in Silicon Valley. \n  \nBiography \nErrol Arkilic is Chief Innovation Officer and Executive Director of University of California\, Irvine Beall Applied Innovation. At UCI\, he leads campus‐wide commercialization activity\, helping researchers turn knowledge into products and services that impact society. Prior to his role at UCI\, he was founder and CEO of M34 Capital. M34 is a private investment company that focuses on seed and early‐stage projects being spun out of academic research labs. He currently sits on three boards: Growcentia\, Inc. NeuroTrainer\, Inc. and Ellis Day Skin Science\, Inc. Previously\, Errol was the founding and lead program director for the National Science Foundation Innovation Corps program (I‐Corps). He led the I‐Corps effort from its inception until July 2013. Prior to this\, he was the lead software and services Program Director for the NSF SBIR program. Before his government service\, Errol was founder and CEO of StrataGent Life Sciences (Acquired by Corium International: CORI) and Manager of Product Engineering at Redwood Microsystems. He has a Ph.D. in Aero/Astro Engineering from MIT. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n  URL:https://leadersinlight.com/event/errol-arkilic-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Errol-Arkilic_square.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20220818T120000 DTEND;TZID=America/Los_Angeles:20220818T130000 DTSTAMP:20260513T150626 CREATED:20220811T162605Z LAST-MODIFIED:20220811T163904Z UID:30894-1660824000-1660827600@leadersinlight.com SUMMARY:Jason B. King\, Ph. D. DESCRIPTION:  \nLaser Beam Shaping for Surgery and Microbiopsy \nAbstract \nLasers are increasingly being used for surgery in a wide range of medical specialties due to their advantages over alternative\nsurgical tools. Advantages include precise material removal\, limited bleeding\, and delivery through optical fibers enabling use\nin body cavities and for minimally invasive surgeries. Advancements in laser technology including new laser wavelengths and\nhigher power continue to improve the performance and implementation of surgical lasers. Temporal beam shaping\, or pulse\nmodulation\, has been implemented into clinical laser systems to increase efficiency of urological surgeries\, leading to faster\,\nsafer procedures. However\, the precise mechanisms of temporally shaped laser ablation are not fully understood. The effects\nof spatial beam shaping on laser tissue ablation have not previously been explored.\nWe aim to understand the impact of temporal and spatial laser beam on laser ablation to improve the performance and\nincrease the applications of laser surgery. Working towards this aim\, a Ho:YAG laser was temporally and spatially altered and\nthe effects on tissue ablation were explored. We explored the mechanisms of pulse modulated ablation through experiments\non phantoms and native kidney stones. We discovered that increased ablation efficiency by pulse modulation is composition\ndependent. Next\, increased ablation efficiency by altering laser spatial shape was explored. We discovered that shaping the\nlaser beam into an annular shape led to an increase in ablation efficiency in both hard and soft tissues. Finally\, we explored\nthe application of spatially shaped laser ablation for laser microbiopsy to harvest sub-microliter (<1 mm3) tissue samples.\nLaser beam shaping\, pulse energy\, and application of cryogen spray cooling were optimized to successfully harvest tissue\nsections with observable histological features. Harvested tissues were imaged with confocal microscopy and “virtual H&E”\nmethods were used to digitally color the images to mimic H&E stained tissue sections. Laser microbiopsy with virtual H&E is\nminimally invasive\, precise\, and provides images in a fraction of the time of the traditional pathology workflow. \n  \nBiography \nDr. Jason King recently graduated with his PhD in biomedical engineering from the University of Texas at Austin. His work\nfocuses on optimization of laser ablation for surgery and biopsy through temporal and spatial laser beam shaping. This work\nincludes computational modeling and ablation experiments aimed at understanding light tissue interactions involved in laser\nablation. His other research interests include confocal microscopy and Raman spectroscopy for cancer diagnosis and\nmonitoring. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n  URL:https://leadersinlight.com/event/jason-b-king-ph-d-2/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/08/Jasonbking.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20220811T120000 DTEND;TZID=America/Los_Angeles:20220811T130000 DTSTAMP:20260513T150626 CREATED:20220811T163755Z LAST-MODIFIED:20220811T163919Z UID:30760-1660219200-1660222800@leadersinlight.com SUMMARY:Olivia L. Lee\, MD DESCRIPTION:  \nConfocal Microscopy for the Evaluation of OcularSurface Disease \nAbstract \nDiagnosis and treatment of ocular surface disease represents a large proportion of the average ophthalmologist’s\npractice. However\, this group of conditions is more heterogeneous and complex than the term “dry eye” conveys.\nFurther investigation of the pathophysiologic mechanisms underlying these conditions are underway\, and in vivo\nlaser scanning confocal microscopy (IVCM) has emerged as a suitable\, relatively novel\, minimally invasive tool for\nobtaining high-resolution images of tissues at the cellular level. Using this imaging device\, the in vivo visualization of\nthe human cornea can be employed to study ocular surface disease in a non-invasive manner. The use of IVCM\nprovides a new approach to evaluating the microscopic morphology of the cornea and our group has applied this to\nthe study of a variety of ocular surface diseases including Sjogrens syndrome\, Mucous Membrane Pemphigoid\, drug\ninduced dry eye\, Neurotrophic Keratitis\, Stevens Johnson Syndrome and more. IVCM is a promising technique for\nthe diagnosis\, prognostication\, staging and stratification of ocular surface disease. This talk will highlight the clinical\nand research applicability of this imaging technique as applied to ocular surface diseases. \n  \nBiography \nDr. Olivia L. Lee is a board-certified UCI Health ophthalmologist who specializes in corneal diseases and uveitis. Dr.\nLee received her medical degree from Baylor College of Medicine in Houston\, Texas\, followed by a residency in\nophthalmology from the New York Eye & Ear Infirmary in New York City\, where she also completed a fellowship in\nuveitis and ocular immunology. She completed a fellowship in cornea\, external disease and refractive surgery at the\nUCLA Stein Eye Institute. Before joining UCI Health\, she served as cornea fellowship director at the Doheny Eye\nCenter UCLA.\nDr. Lee’s research focuses on the use of anterior segment ophthalmic imaging to develop new clinical endpoints to\nobjectively characterize disease severity and guide clinical decision-making. Her clinical interests include\ninflammatory eye disease and complex anterior segment surgery. Dr. Lee has performed all types of corneal and\ncataract surgeries. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n  URL:https://leadersinlight.com/event/olivia-l-lee-md/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/08/Olivia-Lee.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20220726T130000 DTEND;TZID=America/Los_Angeles:20220726T140000 DTSTAMP:20260513T150626 CREATED:20220719T172002Z LAST-MODIFIED:20220719T172002Z UID:30717-1658840400-1658844000@leadersinlight.com SUMMARY:Giulio Guagliumi\, M.D. DESCRIPTION:Intervascular Imaging & Treatment Seminar \nAbout \nDr. Giulio Guagliumi was trained with Master in Interventional Cardiology at the Clinique Pasteur\, Toulouse\, France. He was awarded at Mayo Clinic and St. Mary Hospital\, Rochester in imaging and coronary physiology assessment of vascular response to intracoronary stents. He has a long-standing interventional practice with research expertise in acute myocardial infarction\, stent\, vascular biology\, intravascular imaging\, structural heart disease. Fellow of the Italian Society of Invasive Cardiology since 2003\, he was the Scientific Director of the GISE Congress in 2008-2009 and President of the Italian Society in 2009-2011. H’s fellow of the ESC\, member of EAPCI since 2004\, member of the scientific committee and executive board of EUROPCR; Co-chair EAPCI Program Scientific Committee for the ESC Congress 2012-2014: Expert Chair of the same Committee in 2015. Country champion of the European Stent for Life project in 2010-2014\, to correct inequalities in access to primary-PCI at Italian regional level. Promoter at the EAPCI level of the joint initiative with the largest Japanese society (CVIT). Professor emeritus 2013-2014 at the First Affiliated Hospital of Harbin Medical University. Since 2015\, Dr. Guagliumi was training the interventional cardiology unit personnel at the Second Affiliated Hospital of the Harbin Medical University in clinical use of the intracoronary imaging\, with focus on complex coronary artery disease. He worked as co-director with Prof. Yu and Prof. Jia in multiple national and international educational meetings held in Harbin\, including the most recent ASIA Pacific Hybrid Course on actionable imaging. He was appointed as Honorary Professor at the Harbin Medical University in 2019. \nDuring the COVID-19 disease period Dr. Guagliumi directed the Interventional Unit of PG23 Hospital\, working for all cardiovascular emergencies of the entire Bergamo Province. H’s the leading author of the COVID-19 pathology research publications that identified microthrombi as the major cause of myocardial damage. \nHe has ongoing scientific collaboration with major Universities and research centers including Beckmann Laser Unit\, University of California (Irvine)\, Case Western University (Cleveland\, Ohio)\, Emory University (Atlanta)\, MIT (Boston)\, CV Path Institute (Gaithersburg)\, Wakayama University (Japan)\, Harbin Medical University (China). Principal investigator and member of the Steering Committee in multiple prospective\, randomized\, international multicenter trials in primary-PCI\, coronary stenting\, DES\, intracoronary imaging (IVUS\, OCT). Author of 273 peer reviewed scientific manuscripts\, published across all prestigious cardiology journals\, including New England Journal\, Eur Heart Journal\, Lancet\, Circulation\, JACC\, JACC Imaging\, Eurointervention. He has more than 300 peer reviewed Abstracts presented at the main international scientific conferences. Reviewer of: Eur Heart Journal\, Circulation\, Circ Interv\, JACC\, JACC Interv\, JACC Imaging\, Nature Cardiovascular Medicine\, Eurointervention. Official grader of abstracts and clinical cases submitted to the main Congresses (EuroPCR\, ESC\, TCT\, TCT AP\, ENCORE etc). Dr. Guagliumi is the leading author of imaging chapters in multiple textbooks\, including the OCT chapter of the Interventional Cardiology Textbook- (Editor Topol-Teirstein) for the 6\, 7th\, 8th edition and now officially charged lead author for the new update #9 version. In 2014 he was listed by Thomson Reuters among the most influential researcher in the last ten years from inCites and the Web of Science. \n  \nBiography \nDr. Guagliumi research interest combines scientific and medical training\, expertise in conducting prospective\, randomized trials\, and leadership in the field of high-resolution imaging applied to evaluation of in-vivo stent vascular responses. Dr. Guagliumi a pioneer in clinical use of light-based imaging for evaluating coronary stenting in various prospective\, randomized\, controlled studies conducted in unstable coronary syndromes\, including ST elevation myocardial infarction\, and complex lesion settings (long lesions\, diabetes\, overlapping stents). His group has one of the largest existing experience in the world with Optical Coherence Tomography (OCT) to detect stent-tissue responses at different time points following implantation. His work is based on continuous confront and interaction with pathologists for validating OCT imaging signals  and interpretation and develop surrogate imaging variables predicting stent failure. With this as a foundation the Guagliumi laboratory set the way for conducting innovative in-vivo evaluation and optimization of most of the clinically approved bare metal and drug-eluting stents. H’s involved in early evaluation/discussion of light based technical and software innovations for the clinical use\, including OCT co-registration with coronary angiography\, novel artificial intelligence software implementation for automatic EEL detection and calcium quantification. His most recent publications have focused on how light-based intracoronary imaging helps to identify heterogeneous mechanisms of stent thrombosis and define surrogate imaging variables for anticipating the individual risk profile. Dr. Guagliumi is involved in innovative invasive and non invasive imaging and physiology research projects\, including the use of the light for plaque molding\, and innovative blood flow measurements with CTCA. \n  \nREGISTER HERE FOR ZOOM \nREGISTER HERE FOR IN PERSON \n  URL:https://leadersinlight.com/event/giulio-guagliumi-m-d/ LOCATION:Zoom Event\, CA\, United States ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/07/profile_photo.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220523T120000 DTEND;TZID=UTC:20220523T130000 DTSTAMP:20260513T150626 CREATED:20220515T163102Z LAST-MODIFIED:20220515T163335Z UID:30522-1653307200-1653310800@leadersinlight.com SUMMARY:Michelle Digman\, Ph. D. DESCRIPTION:FLIM and Mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells \nAbstract \nThe hallmark of metabolic alteration of increase glycolysis\, i.e. Warburg effect\, in cancer cells together with atypical extracellular matrix structure may be responsible for tumor cell aggressiveness and drug resistance. While it is it known that tumor cells stiffen the ECM as the tumor progression occurs\, a direct relationship between ECM stiffness and altered metabolism has not been explicitly measured. Here we apply the phasor approach technique in fluorescence lifetime imaging microscopy (FLIM) to measure metabolic alteration as a function of ECM mechanics. We imaged and compared triple-negative breast cancer (TNBC) cells to non-cancerous cells on various ECM stiffness. Our results show that TNBC exhibit a decreased fraction of bound NADH\, (indicative of glycolysis\,) with increasing substrate stiffness. All other cell lines showed little to no change in fraction bound NADH on the varying collagen densities. Dysregulation of mitochondrial motion may contribute to the fueling of bioenergy demands in metastatic cancer. To measure mitochondria motion and analyze their fusion and fission events\, we developed a new algorithm called “mitometer” that is unbiased\, and allows for automated segmentation and tracking of mitochondria in live cell 2D and 3D time-lapse images. Together\, the automated segmentation and tracking algorithms and the innate user interface make Mitometer a broadly accessible tool.? \n  \nBiography \nDr. Digman was awarded a doctorate degree in Chemistry with specialization in Biochemistry from the University of Illinois at Chicago in 2003. She did her postdoctoral work in the Department of Physics at the University of Illinois at Urbana-Champaign in biophysics until this lab moved to the University of California Irvine. She became Optical Bio-Core Director until she joined the BME department in 2013. Her research lab is focused on developing novel biophysical and optical tools to study biological questions with the goal of applying the gained knowledge to the advancement of human medicine. Dr. Digman is AIMBE Fellow\, Scialog Fellow\, Allen Distinguished Investigator in Immunometabolism\, and has won several awards including the NSF-CAREER award\, the Hellman Fellowship\, the Fluorescence Young Investigator Award from the Biophysical Society\, the Faculty Innovation in Teaching award and has received the Henry Samueli Career Development Chair \n  \nREGISTER HERE URL:https://leadersinlight.com/event/michelle-digman-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/05/Digman.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220411T120000 DTEND;TZID=UTC:20220411T130000 DTSTAMP:20260513T150626 CREATED:20220403T121058Z LAST-MODIFIED:20220403T121821Z UID:30476-1649678400-1649682000@leadersinlight.com SUMMARY:Alvin Viray\, J.D. DESCRIPTION:Technology Transfer and Entrepreneurship at UCI \nAbstract \nThis seminar will discuss “technology transfer”\, the process by which UCI (1) protects intellectual property (inventions and software) developed by its faculty\, staff\, researchers and grad students; and (2) commercializes this IP through licensing to an existing company or startup. Also discussed will be the services and resources at UCI’s Beall Applied Innovation for entrepreneurs willing to form a startup based upon the intellectual property they develop at UCI. If you are currently developing intellectual property (IP) at UCI\, would like to do so\, and/or are curious about entrepreneurship and startups\, this seminar will seek to answer any and all your questions: How to submit your invention/software to UCI’s technology transfer office (aka “Research Translation Group”); Who owns my intellectual property; How much do inventors get from UCI’s licensing deal; What is the services and resources are available to me as an entrepreneur doing a startup? \n  \nBiography \nAlvin Viray is the Associate Director of UC Irvine’s technology transfer office\, known as the Research Translation Group (RTG) at UCI’s Beall Applied Innovation. Alvin and his team receives and manages inventions developed by UCI’s faculty\, physicians\, and researchers. He reviews new invention disclosures for patentability and commercial viability. He negotiates and executes various intellectual property agreements on behalf of UCI\, including license agreements for startups and companies. A licensed patent attorney\, Alvin graduated from the University of San Diego School of Law before passing the California Bar and USPTO Patent Bar. Alvin received his bachelor’s from UCI where he frequently guest lectures on topics covering Patents\, Copyrights\, Trademarks\, Licensing\, and Startups. \n  \nREGISTER HERE URL:https://leadersinlight.com/event/alvin-viray-j-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/04/Alvin-Viray.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220331T120000 DTEND;TZID=UTC:20220331T130000 DTSTAMP:20260513T150626 CREATED:20220321T225034Z LAST-MODIFIED:20220403T121006Z UID:30470-1648728000-1648731600@leadersinlight.com SUMMARY:David A. Chalyan\, MD\, MSc DESCRIPTION:Opportunities to Improve Clinical Outcomes with Intravascular Ultrasound (IVUS) in Lower Extremity Revascularizations \nAbstract \nPeripheral vascular disorders are prevalent and mounting health conditions\, particularly in light of the aging population. Both acute and chronic arterial and venous disease result in excess morbidity and mortality and dramatically reduce health-related quality of life. Yet\, despite the expanded indications in guidelines for the types and complexities of vascular lesions resulting in a rising volume of endovascular interventions in general\, we have not seen a meaningful impact on clinical outcomes like amputation rates\, which continue to increase despite better access to peripheral vascular procedures. With the known health outcome benefits of Intravascular Ultrasound (IVUS) in coronary applications and the much higher reintervention rates in peripheral vascular procedures\, the uptake of IVUS has been increasing in lower extremity revascularizations. In this seminar\, we examine the up-to-date evidence\, cross-disciplinary consensus and emerging Real-World Data (RWD) for the role of IVUS in peripheral interventions in order to provide guidance on where this invasive imaging modality may be most beneficial to improve the quality of patient care during lower extremity arterial and venous intervention. \n  \nBiography \nDavid A. Chalyan received his Doctor of Medicine degree from Roy J. and Lucille A. Carver College of Medicine at the University of Iowa and his Master of Science degree in Biomedical Engineering from the University of California\, Irvine where he studied invasive coronary hemodynamics\, angiography-based Fractional Flow Reserve\, and diastolic Fractional Flow Reserve. He currently holds a position in Philips Chief Medical Office \n  \nREGISTER HERE URL:https://leadersinlight.com/event/david-a-chalyan-md-msc/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/03/Chalyan.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220310T120000 DTEND;TZID=UTC:20220310T130000 DTSTAMP:20260513T150626 CREATED:20220301T192752Z LAST-MODIFIED:20220301T192752Z UID:30462-1646913600-1646917200@leadersinlight.com SUMMARY:Dr. Maxim R. Shcherbakov\, Ph. D. DESCRIPTION:Tunable photonic nanostructures for laser pulse control and dynamic imaging \nAbstract \nFor decades\, nanofabrication has been the driving force behind the transformations in electronics. Light-based devices currently experience a similar transition: nanostructure-based photonic elements bear promise to revolutionize several key technology areas\, such as telecommunications\, augmented reality\, remote sensing\, and imaging. In this talk\, I will introduce the concept of tunable photonic nanostructures\, where time can be leveraged as an additional degree of freedom to manipulate the flow of light on demand. In a multi-faceted study\, we will explore how silicon-based nanostructures can be used as ultrafast all-optical switches that can control light with light at subpicosecond timescales and record-low Joule-per-bit counts. Next\, by marrying designer nanostructures to a technologically mature switching agent\, liquid crystals\, we will demonstrate the world’s thinnest lens with an electrically tunable focal spot. We will conclude on remarks how our technology enables lightweight and compact imaging solutions for spatial light modulators\, mixed reality glasses\, head-on displays\, and microscopes\, and outline its potential biomedical applications. \n  \nBiography \nMaxim Shcherbakov is an assistant professor at UCI EECS. He was a postdoctoral associate with the School of Applied and Engineering Physics at Cornell University from 2016 to 2021. He received his M.S. and Ph.D. degrees in Physics from Lomonosov Moscow State University\, Russia. As a deputy group leader at Samsung Advanced Institute of Technology\, his research was focused on wearable electronics\, remote sensing\, and LiDARs. He is an author of more than 50 research papers and book chapters\, and recipient of awards in photonics\, telecommunications and nanotechnology. \n  \nREGISTER HERE URL:https://leadersinlight.com/event/dr-maxim-r-shcherbakov-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2022/03/Maxim-R.-S.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220303T130000 DTEND;TZID=UTC:20220303T140000 DTSTAMP:20260513T150626 CREATED:20220216T231932Z LAST-MODIFIED:20220222T233335Z UID:30392-1646312400-1646316000@leadersinlight.com SUMMARY:Dr. Lilangi Ediriwickrema\, M.D. DESCRIPTION:Applications of Spatial Frequency Domain Imaging in Thyroid Eye Disease \nAbstract \nSpatial frequency domain imaging provides access to multi-spectral absorption and scattering information of biological chromophores and water to provide quantifiable detail about tissue hemodynamics and spectral content. We propose to use SFDI to define an optical signature map characteristic for healthy eyes\, and TED before\, during\, and after treatment. We will use this information to establish clinical end-points and understand strategies to modulate hemodynamics\, osmotic gradients\, and collagen remodeling. \n  \nBiography \nDr. Lilangi Ediriwickrema is a board-certified UCI Health ophthalmologist who specializes in ophthalmic plastic and reconstructive surgery\, neuro-ophthalmology and orbital disease. \nShe received her medical degree from the Yale School of Medicine in New Haven\, Conn. She completed an internship at Memorial Sloan Kettering Cancer Center in New York City and a residency in ophthalmology at the Keck School of Medicine of USC\, where she was chief resident. She also completed a fellowship in neuro-ophthalmology and orbital disease at Johns Hopkins University’s Wilmer Eye Institute in Baltimore\, Md.\, followed by fellowship training in ophthalmic plastic and reconstructive surgery at the Shiley Eye Institute at UC San Diego Health. \n  \nREGISTER HERE URL:https://leadersinlight.com/event/dr-lilangi-ediriwickrema-m-d/ LOCATION:Zoom Event\, CA\, United States ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/02/Dr.-Lilangi-Ediriwickrema.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20220224T120000 DTEND;TZID=UTC:20220224T130000 DTSTAMP:20260513T150626 CREATED:20220214T211746Z LAST-MODIFIED:20220214T214408Z UID:30368-1645704000-1645707600@leadersinlight.com SUMMARY:Dr. Dmitri Lapotko\, Ph.D.\, D.Sc. DESCRIPTION:Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles \nAbstract\nTo improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer\, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale\, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event\, plasmonic nanobubble\, results from a novel physical-biological mechanism. Its mechanical impact was tuned to support cell level diagnostics\, drug release and intracellular injection of genetic or therapeutic payloads\, to enhance chemoradiation therapies in highly resistant and aggressive tumors\, to intraoperatively detect and destroy unresectable residual microtumors\, and to non-invasively detect bad actors\, all in personalized procedures with safe doses of nanoparticles and laser energies. Plasmonic nanobubble platform can be integrated with current or novel medical approaches to improve clinical outcomes where standards of care fail. \nBiography\nDmitri Lapotko obtained his MS in thermal physics and Ph.D. in laser applications from Belarus State University and Doctor of Science in bioengineering from Lyikov Heat and Mass Transfer Institute. His research in biophotonics and nanotechnology in basic\, applied and clinical science resulted in the invention of photothermal microscope for functional analysis of live cells\, laser-generated vapor nanobubbles (plasmonic nanobubbles) as a novel platform for diagnostic\, therapeutic and surgical technologies for cancer\, malaria and cardiovascular disease applications. \n  \nREGISTER HERE \n  URL:https://leadersinlight.com/event/dr-dmitri-lapotko-ph-d-d-sc/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/02/Dmitri-Lapotko.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20211216T120000 DTEND;TZID=UTC:20211216T130000 DTSTAMP:20260513T150626 CREATED:20211208T055702Z LAST-MODIFIED:20211208T055807Z UID:30087-1639656000-1639659600@leadersinlight.com SUMMARY:Song Hu\, Ph. D. DESCRIPTION:Light + Sound: Peering into Brain Function and Metabolism \nAbstract\nExploiting the optical absorption contrast of blood hemoglobin\, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature\, which plays an essential role in supplying oxygen to the biological tissue and maintaining the metabolic activity in vivo. The multi-parametric PAM developed in Dr. Hu’s lab enables\, for the first time\, comprehensive and quantitative characterization of the microvascular structure\, function\, and associated tissue oxygen metabolism at the microscopic level. In this seminar\, Dr. Hu will present their latest progress on the development of PAM and the integration of PAM with other intravital light microscopy techniques for studying brain function and energy metabolism. \nBiography\nDr. Hu received his B.S. and M.S. degrees in Electronic Engineering from Tsinghua University and Ph.D. degree in Biomedical Engineering from Washington University in St. Louis. His research focuses on the development of photoacoustic and optical technologies for high-resolution structural\, functional\, metabolic\, and molecular imaging in vivo. Dr. Hu has published over 70 peer-reviewed articles in journals including Science\, Nature\, Nature Neuroscience\, and Proceedings of the National Academy of Sciences\, and has delivered over 40 invited talks including a Neurotechnologies plenary talk at Photonics West (2018) and a President’s Symposium keynote talk at Annual Microcirculatory Society Meeting (2018). His publications\, including the 4th and 6th most cited articles in the Journal of Biomedical Optics since 2009 and the 5th most cited article in Optics Letters since 2007\, have accumulated around 9\,000 citations (h-index: 37). Dr. Hu is a recipient of the Ralph E. Powe Junior Faculty Enhancement Award (2014)\, the National Science Foundation Faculty Early Career Development (NSF CAREER) Award (2018)\, and the Chan Zuckerberg Initiative Frontiers of Imaging Award (2020). \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/song-hu-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/12/Song-Hu.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20211202T120000 DTEND;TZID=UTC:20211202T130000 DTSTAMP:20260513T150626 CREATED:20211130T053721Z LAST-MODIFIED:20211130T053721Z UID:30060-1638446400-1638450000@leadersinlight.com SUMMARY:Wenbin Tan\, Ph. D. DESCRIPTION:Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations \nAbstract\nSARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular\nabnormalities in Port Wine Stains. In the first part\, we will present our clinical data for the first discovery of dyslipidemia\nin COVID-19 patients which have been substantially recognized. Mechanistically\, we have shown evidence of niche why\nobese subjects are more vulnerable to SARS-CoV-2 attack. Using a spike protein–pseudotyped (Spp) lentivirus with the\nproper tropism of the SARS-CoV-2 spike protein on the surface\, we have found that Spp lentiviruses preferably attack to\nendothelial cells in heart in obese but not normal weight mice\, leading to exaggerated vasculopathy and cardiomyopathy.\nCells with over-expression of Spike protein have impaired lipid metabolic and autophagy formation pathways\, resulting in\nincreased cell death in response to lipotoxicity. In the second part\, we will discuss the clinical molecular pathology of\ninfantile and early childhood PWS to show that (1) PWS is a disease with pathological alterations involving the entire skin\nphysiological milieu; (2) pluripotent cells with the GNAQ (R183Q) may give rise to multilineages in PWS; and (3) exocytosis\nof extracellular vesicles is enhanced in PWS vasculatures. \nBiography\nDr. Tan received his medical degree and master degree in Molecular Biology from XiangYa School of Medicine\, China. He\nreceived his PhD in neurobiology and neurophysiology from University of California\, Los Angeles. He joined Beckman\nLaser Institute at UC Irvine as an assistant project scientist in 2010 under the mentorship of Dr. Stuart Nelson. In 2018\,\nhe joined the department of cell biology and anatomy at School of Medicine University of South Carolina as an associate\nprofessor. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/wenbin-tan-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/11/Wenbin-Tan.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20211014T120000 DTEND;TZID=UTC:20211014T130000 DTSTAMP:20260513T150626 CREATED:20211014T005755Z LAST-MODIFIED:20211014T010429Z UID:29834-1634212800-1634216400@leadersinlight.com SUMMARY:Erin Buckley\, Ph. D. DESCRIPTION:Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies \nAbstract\nOur research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive\, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar\, I will focus on our recent work that uses these tools to identify biomarkers of stroke risk in two high-risk patient populations; subarachnoid hemorrhage and pediatric sickle cell disease. Moreover\, I will talk about how we have advanced the techniques to account for the confounding influences of hematocrit in the sickle cell cohort. \nBiography\nDr. Buckley is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. She is also an assistant professor at the Department of Pediatrics at Emory University. She received her PhD from the Department of Physics and Astronomy from the University of Pennsylvania in 2011 and completed postdoctoral training at the Children’s Hospital of Philadelphia and at Massachusetts General Hospital. Her research focuses on the development and validation of diffuse optical spectroscopies. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/erin-buckley-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/10/Dr-Buckley-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20211007T120000 DTEND;TZID=UTC:20211007T130000 DTSTAMP:20260513T150626 CREATED:20220608T191355Z LAST-MODIFIED:20220608T191355Z UID:30597-1633608000-1633611600@leadersinlight.com SUMMARY:Quinton Smith\, Ph. D. DESCRIPTION:Harnessing Physiological Forces to Drive Stem Cell Fate & Function \nAbstract\nI will be elaborating about how physical cues are crucial to embryonic development\, morphogenic events\, and tissue organization\, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such\, the role of substrate stiffness\, fluid shear stress\, and confinement was interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates\, as opposed to traditionally used rigid plastic surfaces\, promotes efficient endothelial specification in the absence of growth factor supplementation. Leveraging micropatterned domains\, which restrict extracellular matrix accessibility\, also enhances endothelial specification and early lineage organization. Finally\, using a microfluidic platform\, we find that primary cilia\, a microtubule-based mechanosensor\, is crucial to stem cell derived endothelial shear response. Collectively\, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools. \nBiography\nQuinton Smith is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Sue & Bill Gross Stem Cell Research Center\, Irvine. Quinton Smith received his bachelor’s degree from the University of New Mexico in\nchemical engineering and his Ph.D. in 2017 from Johns Hopkins University in chemical and biomolecular engineering. His predoctoral research was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. Additionally\, he was named a Siebel Scholar in 2017. After completing his doctorate\, he trained as a Howard Hughes Medical Institute Hanna Gray Postdoctoral Fellow at the Massachusetts Institute of Technology. Dr. Smith joined the University of California Irvine in Spring 2021 and is currently an Assistant Professor in the Department of Chemical and Biomolecular Engineering and a member of the Sue Bill Gross Stem Cell Research Center. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/quinton-smith-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Quinton_Smith.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210923T120000 DTEND;TZID=UTC:20210923T130000 DTSTAMP:20260513T150626 CREATED:20220608T193312Z LAST-MODIFIED:20220608T193312Z UID:30609-1632398400-1632402000@leadersinlight.com SUMMARY:Andy Shih\, Ph. D. DESCRIPTION:Optical Dissection of Brain Capillary Function \nAbstract\nMy laboratory uses in vivo multiphoton imaging and rodent models to shed light (quite literally) on regulation of cerebral blood flow. In particular\, we have focused recent attention on the vast capillary networks that distribute blood throughout the brain. We use light to both visualize capillary structure and flow\, as well as noninvasively manipulate neurovascular cells that control capillary flow. We specialize in the application and development of in vivo multi-photon imaging approaches to study brain microvascular structure and function in rodents. Our recent findings include the construction of capillary networks during early postnatal development\, regulation of blood flow in adulthood by capillary pericytes\, and capillary changes in gray and white matter that may contribute to metabolic insufficiencies during aging and dementia. I firmly believe that our efforts will provide a unique and physiologically relevant view of microvascular function\, dysfunction\, and repair\, and will yield strategies for protecting vascular function in diseases that degrade the brain’s microvasculature. \nBiography\nAndy Shih is an Assistant Professor in the department of Developmental Biology & Regenerative Medicine at Seattle Children’s Research Institute. Additionally\, he is an assistant professor in the Department of Bioengineering and Department of Pediatrics at the University of Washington. His research focuses on optogenetic approaches to manipulate pericyte contractility in the intact brain\, and studies to delineate pathological features of mural cells in advanced age and small vessel disease. Shih earned a B.S. in Cell Biology and genetics from the University of British Columbia (2010) and Ph.D. in Neuroscience. He has completed his postdoc and been a project scientist from University of California\, San Diego (2012). Shih has been invited to several symposiums and been part of the SfN Nanosymposium chair (Stroke and Injury\, 2016) where he elaborates about his extensive findings & projects. A complete list of his published works in Google Scholar & NIH Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=andy+y+shih \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/andy-shih-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/shih.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210819T120000 DTEND;TZID=UTC:20210819T130000 DTSTAMP:20260513T150626 CREATED:20210810T020201Z LAST-MODIFIED:20210810T020417Z UID:29697-1629374400-1629378000@leadersinlight.com SUMMARY:Stacy Copp\, Ph. D. DESCRIPTION:Fluorophores with a Genome: DNA-Stabilized Silver Clusters as a New Class of Tunable Fluorophores for Microscopy and Biosensing \nAbstract\nBecause near-infrared (NIR) electromagnetic radiation penetrates much farther into biological tissues than visible light\, NIR microscopy allows for noninvasive imaging deep into tissues and even whole organisms. In the second near-infrared window (NIR-II: 1\,000-1\,700 nm)\, biological tissues are transparent up to several centimeters depth. However\, fluorescence microscopy in this spectral window has been limited by the dearth of small\, bright\, and nontoxic NIR-II fluorophores. To address this challenge\, we are investigating a promising class of nanomaterials – DNA-templated silver clusters (Ag-DNAs) – to develop small\, stable\, and modular NIR-II biolabels with broad applicability for deep tissue imaging. Ag-DNAs represent a diverse palette of fluorophores with sequence-encoded sizes of 10-30 atoms and fluorescence emission wavelengths of 400 – 1\,000 nm. I will discuss our growing understanding of the fundamental properties of Ag-DNAs and our development of a high throughput experimental platform coupled with machine learning frameworks to guide discovery of Ag-DNAs within the NIR spectral windows. Using this approach\, we are expanding the color palette of Ag-DNAs well into the NIR\, with exciting future potential to enable deep tissue imaging applications. \nBiography\nStacy Copp is an Assistant Professor of Materials Science and Engineering at the University of California\, Irvine\, where she holds the Samueli Faculty Development Chair and courtesy appointments in the Departments of Physics and Astronomy and Chemical and Biomolecular Engineering. Her research focuses on harnessing information-encoding macromolecules – DNA\, peptides\, and block copolymers – as building blocks for novel optical and electronic materials. Due to the complexity of these molecular materials\, her work incorporates machine learning and data mining for materials study and design. Copp earned a B.S. in physics and mathematics from the University of Arizona (2011) and Ph.D. in physics from UC Santa Barbara. Before joining UCI in 2019\, she was a Hoffman Distinguished Postdoctoral Fellow at Los Alamos National Laboratory (LANL). Copp’s research has been recognized by awards including the AFOSR Young Investigator (2020)\, L’Oreal USA for Women in Science Fellowship (2018)\, and numerous postdoctoral and graduate fellowships. \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/stacy-copp-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/08/STACY_2-copy-300x300-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210729T120000 DTEND;TZID=UTC:20210729T130000 DTSTAMP:20260513T150626 CREATED:20220608T192629Z LAST-MODIFIED:20220608T192629Z UID:30605-1627560000-1627563600@leadersinlight.com SUMMARY:Herdeline (Digs) Ardoña\, Ph. D. DESCRIPTION:Hierarchical Strategies Towards Biointerfacing With Soft Optoelectronic Materials \nAbstract\nThe applications of functional nanomaterials towards biological interfacing continue to emerge in various fields\, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems\, these biomaterials are rarely synthesized with optical and electronic functionalities that could be beneficial for controlling the behavior of excitable cells (e.g.\, neurons and cardiac cells) or for biosensing applications. In this seminar\, I will first describe the development of one-dimensional peptidic nanostructures appended with organic electronic units\, which can facilitate photoinduced energy transfer under aqueous environments. These semiconducting peptide monomers that self-assemble as aligned hydrogels are successfully built according to design principles that allowed for directed photonic energy transport\, sequential electron transport in a multicomponent system\, and transmission or equilibration of voltage or current when incorporated in a transistor device. These soft scaffolding materials\, with tunable molecular to macroscale properties\, offer a unique tissue engineering platform that can locally and synergistically deliver electronic\, topographical\, and biochemical cues to cells. In the second part of the talk\, I will describe how to engineer in vitro models of cells and tissues which enables the understanding of nano-bio or abiotic-biotic interactions at multiple spatial scales. I will specifically describe physiologically relevant models that faithfully recapitulate the native form and function of cells or tissues involved in the systemic biodistribution of common nanomaterials—across biological barriers to target organs. These testing platforms were used to elucidate the dynamic structural and functional outcomes resulting from the exposure of vascular endothelium and myocardium to engineered nanomaterials. Finally\, this presentation will discuss the future applications of biopolymer assemblies with photonic and electronic functionalities as tools for controlling cellular processes and probing biophysical phenomena\, such as mechanotransduction and drug/toxicant permeation across tissues. \nBiography\nHerdeline Ann (Digs) M. Ardoña is originally from Valenzuela City\, Philippines. She received her B.S. in Chemistry (summa cum laude) from the University of the Philippines Diliman in 2011. In 2017\, she completed her Ph.D. in Chemistry at Johns Hopkins\, with funding support from Schlumberger Foundation and Howard Hughes Medical Institute. Her dissertation was focused on understanding the molecular design\, photophysical properties\, and supramolecular principles towards developing pi-conjugated peptide assemblies as bioelectronic nanomaterials. She then worked as a postdoctoral researcher in the Disease Biophysics Group at the Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences at Harvard University. As the 2018-2020 ACS Irving S. Sigal Postdoctoral Fellow\, she investigated the structural and functional impacts of multiple engineered nanomaterials through microphysiological platforms and biohybrid models. Digs started as an Assistant Professor at the UCI Department of Chemical and Biomolecular Engineering in Fall 2020. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/herdeline-digs-ardona-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Ardona_Photo.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210617T120000 DTEND;TZID=UTC:20210617T130000 DTSTAMP:20260513T150626 CREATED:20220608T192056Z LAST-MODIFIED:20220608T192056Z UID:30601-1623931200-1623934800@leadersinlight.com SUMMARY:Philip Scumpia\, Ph. D. DESCRIPTION:Translating an understanding of the cutaneous microenvironment into diagnostics and treatments for wounds\, cancers\, and inflammatory dermatoses \nAbstract\nImmune cells are the first responders to injury\, pathogens\, or malignancy. The various components of the tissue microenvironment dictate what immune cells do when they reach different tissues. The Scumpia lab studies how different components of the unique cutaneous microenvironment affect outcome following wounding\, bacterial infection\, or cancer. The overall goal is to develop an understanding of the cutaneous microenvironment regulates skin disease and to translate this knowledge into new diagnostics and therapies. \nBiography\nDr. Scumpia received a BS in Microbiology and Cell Sciences from the University of Florida. He received his M.D. and PhD. from the University of Florida where he studied the immunobiology of sepsis. He completed his residency and fellowship training in Dermatology and Dermatopathology at UCLA. He is currently an Assistant Professor in the Department of Medicine at UCLA where he studies how various components of the cutaneous microenvironment including nerves\, lipids\, and extracellular matrix\, regulate skin diseases. The goal is to translate this understanding into novel diagnostics and potential therapeutics. He is currently a member of the American Academy of Dermatology and the Society of Investigative Dermatology. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/philip-scumpia-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:2022 Virtual Seminar Series ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Scumpia.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210506T090000 DTEND;TZID=UTC:20210506T100000 DTSTAMP:20260513T150626 CREATED:20210416T041739Z LAST-MODIFIED:20210416T041739Z UID:29270-1620291600-1620295200@leadersinlight.com SUMMARY:Dan Cojoc\, Ph. D. DESCRIPTION:Cell Mechanics by Light \nAbstract\nLiving cells are active matter characterized by mechanical properties as stiffness and deformability and morphological parameters as shape and volume. Genetic or pathogenic modifications of these properties can affect cell behavior. Since these transformations are potential indicators in various pathologies\, cell mechanics characterization has progressively gained interest. However\, due to their variability it is difficult to establish absolute values for these properties\, especially when different measurement methods are applied. In the first part\, I will discuss this issue presenting results obtained with Optical Tweezers (OT)\, Atomic Force Microscopy (AFM) and Digital Holographic Microscopy (DHM) and showing that using more than one type of cell allows to confront the methods\, confirm the results and cell behavior. Cells can detect and respond to pressure and forces exerted by the cellular environment in various forms. Thus\, mechanosensitive signaling pathways are activated\, inducing cytoskeleton reshaping and force generation as a response to these mechanical stimuli. How big and how much localized is the force inducing a mechanical stimulation\, and what is its time extent? These questions are still to be elucidated. In the second part of the talk\, I will argue on the use of OT as an adequate tool to study cell mechanotransduction. Using a novel OT setup\, mechanical stimuli are applied under controlled conditions\, the force and indentation of which are measured directly and precisely. Neuronal cells are locally stimulated with piconewton forces which trigger Ca2+ transients in the cell and induce cytoskeletal modifications. \nBiography\nDr. Dan Cojoc is a Senior Scientist at the Institute of Materials of the National Research Council of Italy (CNR). With a background in Optical Engineering (M.S.) and Technical Physics (Ph.D.) from the University “Politehnica” of Bucharest\, Romania\, he has contributed to develop microscopy devices and techniques for applications in nanotechnology and biophysics. He has created various optical tweezers setups for sample manipulation and force measurements and integrated them with X-ray diffraction\, holographic microscopy\, laser microsurgery and fluorescence imaging for the study of biological samples. Currently\, Dr. Cojoc’s laboratory applies optical tweezers and digital holographic microscopy techniques to probe cell mechanics of blood\, cancer and neuronal cells. The interaction of light with the matter is exploited to apply tiny forces to cells and measure their local deformations to derive the mechanical properties or examine mechanotransduction mechanisms. Dr. Cojoc has been engaged in several interdisciplinary projects and has been awarded with research grants and fellowships from Italy\, Croatia\, Spain\, Germany\, France\, Romania and China. He published more than 130 papers\, keeps 3 patents\, is co-author of 11 chapter books and reviewer for more than 10 scientific journals. Dr. Cojoc is an adjunct professor at the University of Trieste and at the International School of Advanced Studies (SISSA) Trieste\, lecturing Experimental Biophysics and Advanced Optical Microscopy courses for undergraduates and tutoring PhD students in Nanotechnology and Neurobiology programs. \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/dan-cojoc-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/04/Dan-Cojoc.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210422T120000 DTEND;TZID=UTC:20210422T130000 DTSTAMP:20260513T150626 CREATED:20210416T014528Z LAST-MODIFIED:20210416T014528Z UID:29266-1619092800-1619096400@leadersinlight.com SUMMARY:Nozomi Nishimura\, Ph. D. DESCRIPTION:In vivo multiphoton microscopy of microvasculature and inflammation: Lessons from the brain and a look at the heart \nAbstract\nIn vivo multiphoton microscopy enables the visualization of dynamics at the cellular scale and is an ideal tool for studying the interactions of cells in vivo. Such imaging has revealed the importance of maintaining vascular health\, even in the smallest blood vessels and the capillary bed. In an example in the brain\, we found in mouse models of Alzheimer’s disease (AD)\, that stalled blood flow in a small number of capillaries caused by neutrophils plugs had a surprisingly large effect on total blood flow. Rescue of blood flow led to rapid improvements in short-term memory. We also used laser-induced lesions to study the effects of small-vessel occlusions on inflammation and on amyloid-beta deposits. We discovered rapid alterations in plaques\, both dissolution and increase in deposits\, that were previously thought to be stable structures. We recently adapted these experimental capabilities to organs with motion including the heart. In models of heart failure\, intravital imaging of cardiac vasculature suggests that leukocyte obstruction of capillaries may play a role in the disease. Intravital vital imaging also enables measurements of calcium dynamics and contraction in cardiomyocytes and concurrent dynamics in inflammatory cells. \nBiography\nNozomi Nishimura is an Associate Professor in the Meinig School of Biomedical Engineering at Cornell University and develops optical tools for studying in vivo cell behaviors in disease. Her PhD is in physics from the University of California at San Diego with Prof. David Kleinfeld where she studied blood flow in the brain of rodents and developing laser-based models of small stroke. She came to Biomedical Engineering at Cornell in 2006 to do a postdoc with Prof. Chris Schaffer and later joined the faculty in 2013.To study the complex actions of cells in vivo\, her lab develops intravital multiphoton microscopy imaging methods that reveal how cells function\, move and interact. Injury triggers the recruitment and activation of many immune and inflammatory cell types that\, together with the local cells\, determine the course of the disease progression. The goal is to develop methods to visualize all of these cells at once and quantify cell actions and function. She applies these tools in many systems\, but has particular interests in studying the effects of microvascular dysfunction in the brain. Her lab studies the role of microvascular occlusions in Alzheimer’s disease and neurodegeneration. These methods were recently adapted for the beating mouse heart providing new capabilities to study single cell function and cardiac microvasculature. Recent work expanding into the intestine revealed novel behaviors such as motion and force actuation by stem cells in response to injury.\nSponsored by the Berns Family LAser and Microbeam Program \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/nozomi-nishimura-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/04/Nishimura.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210401T120000 DTEND;TZID=UTC:20210401T130000 DTSTAMP:20260513T150626 CREATED:20210225T054811Z LAST-MODIFIED:20210225T055556Z UID:29190-1617278400-1617282000@leadersinlight.com SUMMARY:Ji-Xi Cheng\, Ph. D. DESCRIPTION:Harnessing Photons for Label-free Chemical Imaging\, High-Precision Neuromodulation\, and Killing of Superbugs \nAbstract\nPhotons are unique in that they can directly interact with molecules\, the foundation of life. I will give an overview of our biophotonics research at three levels of interactions. At the weak interaction regime\, I will present label-free chemical microscopy utilizing spectroscopic signals for discovery of molecular signatures related to cancer aggressiveness and antimicrobial resistance. At the moderate interaction regime\, I will present non-genetic high-precision optoacoustic stimulation of nervous system. At the strong interaction regime\, I will show that photolysis of intrinsic chromophores could effectively sensitize resistant pathogens to antibiotics and anti-fungal drugs. \nBiography\nJi-Xin Cheng is currently the Inaugural Theodore Moustakas Chair Professor in Photonics and Optoelectronics at Boston University. Cheng and his team are constantly at the forefront of chemical imaging in innovation\, discovery\, commercialization\, and clinical translation. For his pioneering contributions to the field of vibrational spectroscopic imaging\, Cheng received the 2020 Pittsburg Spectroscopy Award from the Spectroscopy Society of Pittsburg\, the 2019 Ellis R. Lippincott Award from OSA\, Society for Applied Spectroscopy\, Coblentz Society\, and the 2015 Craver Award from Coblentz Society. Cheng is authored in over 270 peer-reviewed articles with an h-index of 79 (Google Scholar). His research has been supported by over 30 million ($) fund from federal agencies including NIH\, NSF\, DoD\, DoE and private foundations including the Keck Foundation. Cheng is a Fellow of Optical Society of America\, a Fellow of American Institute of Medicine and Biological Engineering\, and associate editor of Science Advances. \n  \nREGISTER HERE \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/ji-xi-cheng-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/02/Ji-Xin-Cheng-Headshot.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20210324T100000 DTEND;TZID=UTC:20210324T110000 DTSTAMP:20260513T150626 CREATED:20210220T050239Z LAST-MODIFIED:20210220T050956Z UID:29168-1616580000-1616583600@leadersinlight.com SUMMARY:Dr. Christoph Hitzenberger\, Ph. D. DESCRIPTION:From Ocular Biometry to Cellular Resolution – and Multifunctional OCT – Coherence Ranging and Imaging in the Human Eye over 35 Years \nAbstract \nIn the mid 1980s\, first applications of low coherence interferometry (LCI) to tissue metrology and analysis were reported. Starting from one-dimensional ocular biometry\, the technology has evolved into a high-speed\, 3-dimensional imaging technology\, now known as optical coherence tomography (OCT)\, with a multitude of functional extensions that has revolutionized ocular diagnostics. This talk illustrates the evolution of the technology over a third of a century\, as seen from a Viennese perspective. Starting with first axial eye length measurements by LCI\, a bridge is spanned to modern high-speed\, high-resolution\, and multifunctional OCT\, including some examples of current research in the OCT labs at Medical University of Vienna. \nBiography \nChristoph K. Hitzenberger is Professor of Medical Physics and Vice Chair of the Center for Medical Physics and Biomedical Engineering\, Medical University of Vienna\, and Editor-in-Chief of Biomedical Optics Express. He works in Biomedical Optics since 1987 and is one of the pioneers of low coherence ocular biometry and optical coherence tomography. Among his most important contributions to these fields were the introduction of the optical A-scan in 1990\, the first demonstration of Fourier domain OCT methods in 1995\, and pioneering work in polarization sensitive OCT since 2000. He is Fellow of OSA and of SPIE; his pioneering contributions to OCT were awarded with the Russ Prize of the US National Academy of Engineering in 2017 and with the Austrian Cross of Honour for Science and Art\, First Class. \n  \nREGISTER HERE \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program URL:https://leadersinlight.com/event/ocular-biometry/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2021/02/hitzenberger-headshot.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20201215T003000 DTEND;TZID=UTC:20201215T140000 DTSTAMP:20260513T150626 CREATED:20201202T023609Z LAST-MODIFIED:20201212T220049Z UID:29027-1607992200-1608040800@leadersinlight.com SUMMARY:Bioengineering for COVID-19 DESCRIPTION:  \nBioengineering for COVID-19: Rapid Acceleration of Diagnostics (RADx) at Unprecedented Speed and Scale \nJoin Beall Applied Innovation and Beckman Laser Institute for a presentation from Bruce Tromberg\, director of the National Institute of Biomedical Imaging and Bioengineering. Bruce will discuss how the NIH launched the Rapid Acceleration of Diagnostics initiative in response to the COVID-19 crisis. \nThe virtual event is hosted by Richard Sudek\, executive director at Beall Applied Innovation and chief innovation officer at UCI\, and Tom Milner\, UCI professor\, Surgery and Biomedical Engineering and director at Beckman Laser Institute & Medical Clinic. \nSpeaker\nBruce Tromberg \nDirector @The National Institute of Biomedical Imaging and Bioengineering \nDr. Tromberg is the Director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) and leads NIBIB’s $500M Rapid Acceleration of Diagnostics (RADx Tech) innovation initiative for increasing SARS-COV-2 testing capacity and performance. Prior to joining NIH in January 2019\, he was a professor of Biomedical Engineering and Surgery at the University of California\, Irvine (UCI) where he served as director of the Beckman Laser Institute and Medical Clinic (BLIMC) and the Laser Microbeam and Medical Program (LAMMP)\, an NIH National Biomedical Technology Center. Dr. Tromberg specializes in the development of optics and photonics technologies for biomedical imaging and therapy. He has co-authored more than 450 publications and holds 21 patents in new technology development as well as bench-to-bedside clinical translation\, validation and commercialization of biomedical devices. \nREGISTER HERE URL:https://leadersinlight.com/event/bioengineering-for-covid-19/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:Symposium ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2020/12/Bruce.jpg END:VEVENT END:VCALENDAR