BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Beckman Laser Institute - ECPv6.16.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://leadersinlight.com X-WR-CALDESC:Events for Beckman Laser Institute REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20210314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20211107T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20220313T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20221106T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20230312T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20231105T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20240310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20241103T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20250309T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20251102T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20260308T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20261101T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20270314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20271107T090000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260312T120000 DTEND;TZID=America/Los_Angeles:20260312T130000 DTSTAMP:20260513T121947 CREATED:20260213T192223Z LAST-MODIFIED:20260303T185244Z UID:33833-1773316800-1773320400@leadersinlight.com SUMMARY:Junjie Yao\, PhD DESCRIPTION:From Light to Sound: Imaging\, Treating\, and Building Tissues at Depth\nAbstract \nIntegrating light and sound\, our research weaves engineering innovations that map\, treat\, and ultimately engineer living tissues at depthsunreachable by conventional optical methods—spanning scales from single cells to whole organs. \n(1) Seeing deep with clarity and color. Our photoacoustic imaging (PAI) converts optical absorption into ultrasound emission\, enabling multi-scale functional and molecular imaging. We accelerate photoacoustic microscopy (PAM) by 1000×\, unlocking real-time observations of neural activity\, placental development\, and the remarkable transparency of glassfrogs. Using genetically encoded photoswitchable probes\, we further enhance the molecular sensitivity of photoacoustic computed tomography (PACT) by 1000×\, enabling reliable detection of cancer metastasis\, tissue regeneration\, and neuronal signaling in deep tissues. (2) Treating deep with precision. We translate deep-tissue ultrasound technologies into clinical practice through super-resolution passive cavitation mapping (SR-PCM) integrated with laser lithotripsy. By localizing laser-induced cavitation with >10× sub-diffraction precision\, SR-PCM provides real-time\, closed-loop surgical guidance that significantly improves the efficiency and safety of kidney-stone treatments. (3) Building deep with safety. Our ultrasound volumetric in-situ printing (UltraVIP) technology overcomes the penetration limits of light-based bioprinting by >100×\, using focused ultrasound energy to fabricate intricate three-dimensional structures within deep-seated tissues. UltraVIP expands the possibilities of regenerative medicine\, minimally invasive surgery\, and in situ tissue engineering. Together\, these advances form a unified research pipeline that harnesses light–sound energy conversion and control for noninvasive imaging\, image-guided intervention\, and deep-tissue biofabrication—paving the way for next-generation diagnostic\, therapeutic\, and regenerative technologies. \nBiography \nDr. Junjie Yao is Jeffrey N. Vinik Associate Professor of Biomedical Engineering and Bass Chair Professor at Duke University\, with a secondary appointment at Duke Neurology. He is also the Associate Director of Duke Fitzpatrick Institute for Photonics. Dr. Yao earned his B.S. (2006) and M.S. (2008) degrees from Tsinghua University (Beijing\, China). He further completed his doctoral study at Washington University in St. Louis in 2013 and postdoctoral training in 2016\, under the mentoring of Dr. Lihong V. Wang. At Duke\nUniversity\, Dr. Yao’s research involves the conversion and control of light and sound for high-speed functional brain imaging\, deep-tissue molecular imaging\, early-stage cancer detection\, super-resolution passive cavitation mapping\, and through-tissue ultrasound printing. Dr. Yao’s Google Scholar Citation is ~15500\, with an H-index of 59 and i10-index of 160. Dr. Yao’s contributions to the field of biomedical engineering have been recognized with IEEE Photonic Society Young Investigator Award (2019)\, National Jewish Fund Faculty Fellow (2021)\, NSF CAREER Award (2022)\, Nature Rising Stars of Light Award (2023)\, IC-UEBA Young Investigator Award (2025)\, Highly Citied Researcher List by Clarivate (2025)\, and Stansell Family Distinguished Research Award (2025). Dr. Yao is the Associate Editor of Science Advances\, Journal of Biomedical Optics\, BMC Medical Imaging\, and Journal of Photoacoustics. Dr. Yao was elected as a Fellow of OPTICA (2022)\, SPIE (2025) and AIMBE (2025)\, ‘for breaking the limits of photoacoustic imaging in resolution\, speed\, and functionality\, and translating the technical innovations to theragnostic impacts’. For more detailed information about Dr. Yao’s research\, please visit his website at http://photoacoustics.pratt.duke.edu/. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/junjie-yao-phd/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2026/02/Junjie-Yao-192.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260226T120000 DTEND;TZID=America/Los_Angeles:20260226T130000 DTSTAMP:20260513T121947 CREATED:20260213T182511Z LAST-MODIFIED:20260213T192346Z UID:33829-1772107200-1772110800@leadersinlight.com SUMMARY:Anna-Karin Gustavsson\, PhD DESCRIPTION:Mapping cellular function with 3D single molecule tracking and super-resolution microscopy\nAbstract \nCellular function is governed by the molecular organization and interactions at the nanoscale. In this talk I will demonstrate our recent developments for improved 3D single-molecule tracking of dynamics and super-resolution imaging of nanoscale structures throughout mammalian cells and showcase applications of our approaches for cellular imaging. \nI will describe our developments of light sheet microscopy platforms that reduce fluorescence background\, photobleaching\, and the risk of photodamaging sensitive samples. Combined with point spread function (PSF) engineering\nfor nanoscale localization of individual molecules in 3D\, deep learning for analysis of overlapping emitters\, and a novel 3D nanoprinted microfluidic chip for environmental control\, our platforms offer whole-cell multi-target 3D single-molecule superresolution imaging with improved accuracy\, precision\, and imaging speed. Next\, I will demonstrate how we integrate the\noptical sectioning capabilities of light sheet illumination with uniform\, flat-field epi- and TIRF illumination to achieve more precise and accurate quantitation of single-molecule data. I will also demonstrate novel long axial-range double-helix PSFs and show that they offer stitching-free\, 3D super-resolution imaging of whole mammalian cells\, simplifying the experimental and analysis procedures for obtaining volumetric nanoscale structural information. Furthermore\, I will show that deep learning-based analysis drastically improves the achievable imaging speed and resolution with these PSFs. Finally\, I will describe our recent developments and applications of dCas9-based labels for flexible and long-term tracking of endogenous\, non-repetitive genomic loci in live human cells with excellent spatiotemporal resolution. \nThese imaging approaches are versatile and can be utilized to study molecular dynamics\, nanoscale structures\, and molecular mechanisms to address a broad range of chemical\, biological\, and biomedical questions related to cellular function and pathogenesis. \nBiography \nDr. Gustavsson joined the faculty at Rice University in 2020 as a CPRIT Scholar in Cancer Research and the Norman Hackerman-Welch Young Investigator Chair. At Rice\, she founded and serves as Director of the Center for Nanoscale Imaging Sciences. Her research group strives to gain detailed information about cellular nanoscale structures\, dynamics\, and molecular mechanisms by designing and applying innovative and versatile optical imaging tools. Dr. Gustavsson received her Ph.D. in Physics from the University of Gothenburg\, Sweden. Her graduate work focused on studying rhythms and dynamic responses in single cells by combining and optimizing techniques such as fluorescence microscopy\, optical tweezers\, and microfluidics. Upon completion of her graduate work\, Dr. Gustavsson joined the group of Nobel Laureate W. E. Moerner at Stanford University as a Postdoctoral Fellow. Her research focused on the development and application of 3D single-molecule super-resolution microscopy for cellular imaging and included the implementation of light sheet illumination for optical sectioning of mammalian cells. Her work has been recognized with multiple honors\, awards\, and fellowships\, most notably the FEBS Journal Richard Perham Prize\, the 3-year Swedish Research Council International Postdoctoral Fellowship\, the PicoQuant Young Investigator Award\, the NIH K99/R00 Pathway to Independence Award\, the CPRIT Recruitment of First-Time Tenure-Track Faculty Members Award\, the Scialog: Advancing Bioimaging Fellowship\, the Edward S. and Fofo Lewis Chemistry Research Award\, and the NSF CAREER Award \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/anna-karingustavsson/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2026/02/Anna-Karin-Gustavsson-photo-192.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260122T120000 DTEND;TZID=America/Los_Angeles:20260122T130000 DTSTAMP:20260513T121947 CREATED:20260213T223304Z LAST-MODIFIED:20260213T223304Z UID:33842-1769083200-1769086800@leadersinlight.com SUMMARY:Wenbin Tan\, PhD DESCRIPTION:Induced pluripotent stem cells and vascular organoids assemble capillary malformation phenotypes: insights and challenges\nAbstract \nRecent advances in induced pluripotent stem cell (iPSC) technology have transformed vascular malformation research by enabling the development of human-relevant\, genotype-specific disease models. Patient-derived or genome-edited iPSCs can be differentiated into endothelial cells and assembled into three-dimensional vascular organoids that recapitulate\nmany hallmarks of pathological features. In our recent work\, we established capillary malformation (CM)–derived iPSCs and generated induced endothelial cells and vascular organoids that mirror key disease phenotypes\, including enlarged vascular lumens\, endothelial hyperproliferation\, and dysregulated signaling. Notably\, patient-derived iPSCs and iPSC derived ECs also exhibited heterogeneity in laser-treatment responses\, reflecting the clinical spectrum observed among individuals with CM. Together\, these clinically relevant stem cell–based systems provide powerful platforms for dissecting mechanisms of vascular pathologies and for screening therapeutic candidates in a controlled\, patient-specific context. \nBiography \nDr. Tan is an Associate Professor in the Department of Cell Biology and Anatomy and Director of the Stem Cell and Organoid Core at the University of South Carolina School of Medicine. He is also affiliated with the Cardiovascular Research Center and the Department of Bioengineering at the University of South Carolina. He received his Ph.D. in Neurophysiology and Neurobiology from the University of California\, Los Angeles in 2008\, where his early work focused on rhythmic brainstem neurons involved in the neural control of breathing under Dr. Jack L. Feldman’s mentorship. In 2010\, he joined Dr. J. Stuart Nelson’s group in the Department of Surgery and the Beckman Laser Institute at the University of California\, Irvine\, where he began his research on congenital vascular malformations—a dramatic and unexpected shift from studying neurons to endothelial cells. Dr. Tan is deeply grateful to Dr. J. Stuart Nelson\, Dr. Dongbao Chen\, and the Beckman Laser Institute for their mentorship and the supportive academic environment that shaped his transition to this field. In 2018\, he joined the University of South Carolina School of Medicine. On the East Coast\, he continues to miss the authentic food and consistently pleasant climate of Southern California. He also greatly appreciates the natural beauty and welcoming environment of South Carolina. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/wenbin-tan-phd/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2026/02/Wenbin_Headshot.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251204T120000 DTEND;TZID=America/Los_Angeles:20251204T130000 DTSTAMP:20260513T121947 CREATED:20251121T190700Z LAST-MODIFIED:20251121T190700Z UID:33679-1764849600-1764853200@leadersinlight.com SUMMARY:Dr. Goldman DESCRIPTION:Single molecule fluorescence approaches reveal that DEAD-Box RNA helicases cluster in dynamic hubs for protein synthesis initiation\nAbstract \nDEAD-box helicases\, DDX3 and eukaryotic initiation factor 4A (eIF4A)\, play essential roles in translation initiation\, cytoplasmic surveillance for foreign RNAs and in facilitating cellular stress response. Using multi-parameter confocal fluorescence burst spectroscopy\, we discovered that sex chromosome-encoded helicases\, DDX3X and DDX3Y\, form 20 nm RNA-protein clusters (RPCs) containing a few RNA duplexes and dozens of protein subunits. This assembly occurs at nanomolar concentrations\, far below the critical micromolar concentration threshold for liquid-liquid phase separation. N-terminal and C-terminal intrinsically disordered regions (IDRs) are required for RPC formation of DDX3s. eIF4A\, with much smaller IDRs\, does not form RPCs without other protein partners. But with cofactors eIF4B\, which is highly disordered\, and eIF4G\, a scaffolding factor needed to recognize and activate authentic capped mRNAs\, the RPCs appear and again facilitate the helicase (unwinding) function. A mutation in the RNA-binding module of eIF4B causes reduced RPC formation\, reduced phase separation into condensates\, and reduced activity. Faster diffusion of the mutant eIF4B in HeLa cells relative to wild type implies that these features apply in cells as well as in vitro. As DEAD-Box helicases are not processive\, RPCs may be required for unwinding of larger mRNA secondary structures during initiation of protein synthesis and in formation of stress granules as a cellular protective mechanism. \nBiography \nDr. Goldman obtained a BS in Electrical Engineering from Northwestern University in 1969 and MD and PhD in Physiology from the University of Pennsylvania in 1975. He was Post-Doctoral Fellow at University College London under Professor Sir Andrew F. Huxley and Robert M Simmons until 1980 at which time he joined the Physiology Department of the School of Medicine\, University of Pennsylvania. He moved his laboratory and appointment to University of California in Davis in 2023. Dr. Goldman has developed novel instrumentation for biophysical studies on muscle contraction\, non-muscle molecular motors\, protein synthesis and RNA helicases. He introduced photochemical approaches to transient dynamics and mechanochemistry of these biophysical systems\, including caged ATP photolysis\, high speed optical traps (laser tweezers)\, stable isotope oxygen exchange\, single molecule nanometer tracking and polarized total internal reflection fluorescence microscopy. He was awarded the Bowditch Lectureship of the American Physiological Society\, Kinosita Single Molecule Award\, President\, and Fellow of the Biophysical Society\, Storer Lectureship at UC Davis among others. He is a Fellow of the American Academy of Arts and Sciences\, American Association for the Advancement of Science and elected Member of the US National Academy of Science. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/dr-goldman/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/11/Yale-Goldman.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251120T120000 DTEND;TZID=America/Los_Angeles:20251120T130000 DTSTAMP:20260513T121947 CREATED:20251121T185752Z LAST-MODIFIED:20251121T185841Z UID:33668-1763640000-1763643600@leadersinlight.com SUMMARY:Wei Gao\, PhD DESCRIPTION:Body-Interfaced Biosensors\nAbstract \nThe rise of personalized medicine is reshaping traditional healthcare\, enabling predictive analytics and tailored treatment strategies. In this talk\, I will discuss our progress in developing wearable\, implantable\, and ingestible electrochemical biosensors for real-time molecular analysis. These bioelectronic systems autonomously access and sample diverse body fluids—including sweat\, interstitial fluid\, gastrointestinal fluid\, wound exudate\, and exhaled breath condensate—enabling continuous monitoring of key biomarkers such as metabolites\, nutrients\, hormones\, proteins\, and drugs during various activities. To facilitate scalable\, cost-effective manufacturing of these high-performance\, nanomaterial-based sensors\, we employ laser engraving\, inkjet printing\, and 3D printing techniques. The clinical utility of our biosensors is being evaluated in human and animal studies\, focusing on applications such as stress and mental health assessment\, precision nutrition\, chronic disease management\, and personalized drug monitoring. Additionally\, I will highlight our efforts in energy harvesting from both the body and the environment\, opening the door to battery-free\, wireless biosensing technologies. By integrating electrochemical biosensing with advanced bioelectronics\, we aim to revolutionize personalized healthcare\, offering new possibilities for diagnostics\, continuous monitoring\, and therapeutic interventions. \nBiography \nWei Gao is a Professor of Medical Engineering and Heritage Medical Research Institute Investigator at the California Institute of Technology. He earned his Ph.D. from the University of California\, San Diego in 2014\, followed by a postdoctoral fellowship at the University of California\, Berkeley from 2014 to 2017. He is an Associate Editor of Science Advances\, npj Flexible Electronics\, Biosensors and Bioelectronics\, and Sensors & Diagnosis. He is a recipient of NSF Career Award\, ONR Young Investigator Award\, IAMBE Early Career Award\, Sloan Research Fellowship\, Pittcon Achievement Award\, IEEE EMBS Early Career Achievement Award\, IEEE EMBS Technical Achievement Award\, IEEE Sensor Council Technical Achievement Award\, MIT Technology Review 35 Innovators Under 35\, and Falling Walls Breakthrough of the Year in Engineering and Technology. He is a World Economic Forum Young Scientist\, a Highly Cited Researcher (Web of Science). He is an elected Fellow for AIMBE and RSC. His research interests include wearable biosensors\, digital medicine\, bioelectronics\, flexible electronics\, additive manufacturing\, and micro/nanorobotics.\nFor additional information about Gao’s research\, please visit www.gao.caltech.edu. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/wei-gao-phd/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/11/Wei-Gao-192x192-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251013T120000 DTEND;TZID=America/Los_Angeles:20251013T130000 DTSTAMP:20260513T121947 CREATED:20251121T181548Z LAST-MODIFIED:20251121T181548Z UID:33653-1760356800-1760360400@leadersinlight.com SUMMARY:Dr. Haichong (Kai) Zhang DESCRIPTION:Listening to the Sound of Light with A Robot: Fusion of Imaging and Robotics for Healthcare\nAbstract \nMedical robotics has been widely applied in areas such as surgical assistance\, enabling higher precision\, reduced fatigue\, and enhanced performance\, and tele-operation\, allowing surgeons to perform procedures remotely without being physically present with the patient. A key enabler of medical robotics is imaging\, which has rapidly evolved over the past two decades to support more minimally invasive\, personalized\, and low-risk diagnostic and therapeutic approaches. My research group focuses on the intersection of medical robotics\, sensing\, and imaging\, with the aim of developing robotic-assisted imaging systems and image-guided robotic interventional platforms. We emphasize ultrasound and photoacoustic (PA) imaging due to their real-time capabilities\, accessibility\, and compact form\, which make them ideal for integration into interventional procedures. In this talk\, I will highlight two major research thrusts in our lab. First\, I will present our work on PA-based functional image-guided interventions\, which provide functional information such as disease states and therapy progression. This approach enables high-sensitivity\, multimodal robotic-assisted surgical guidance. Specifically\, we are investigating the use of molecular-targeted contrast agents to delineate prostate cancer using spectroscopic PA (sPA) imaging\, and a label-free sPA method to monitor therapeutic progression during cardiac ablation. Second\, I will discuss autonomous robotic imaging\, which aims to reduce user dependency during image acquisition\, resulting in higher-quality images and more comprehensive scanning. This includes our development of a robotic optical coherence tomography (OCT) platform for quantifying microstructural parameters of human kidneys during transplant surgeries to assess organ viability\,and an autonomous ultrasound robot for diagnosing lung diseases. These advancements in robotic imaging and intervention have the potential to significantly enhance both diagnostic capabilities and therapeutic outcomes\, paving the way for the next generation of medical imaging and robotics. \nBiography \nDr. Haichong (Kai) Zhang is an Associate Professor in Biomedical Engineering and Robotics Engineering with an appointment in Computer Science at Worcester Polytechnic Institute (WPI). He is the founding director of the Medical Frontier Ultrasound Imaging and Robotic Instrumentation (Medical FUSION) Laboratory. His research interests include advanced medical imaging and robotic instrumentation with an emphasis on ultrasound and photoacoustics. Dr. Zhang received his B.S. and M.S. in Human Health Sciences from the Kyoto University\, Japan\, and subsequently earned his M.S. and Ph.D. in Computer Science from the Johns Hopkins University. Dr. Zhang is the recipient of the NIH Director’s Early Independence Award (DP5) in 2019 and the Early Investigator Research Award from the Department of Defense Prostate Cancer Research Program in 2018. He has served as a Program Committee Member for two tracks at the Image-Guided Procedures\, Robotic Interventions\, and Modeling and Ultrasonic Imaging and Tomography at the SPIE Medical Imaging Conference. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/dr-haichong-kai-zhang/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/11/HaichongZhang-192x192-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250925T120000 DTEND;TZID=America/Los_Angeles:20250925T130000 DTSTAMP:20260513T121947 CREATED:20251121T183409Z LAST-MODIFIED:20251121T183553Z UID:33659-1758801600-1758805200@leadersinlight.com SUMMARY:Guillem Pratx\, PhD DESCRIPTION:Small but mighty: Micropysiological models for simulating complex clinical oncology workflows\nAbstract \nMicrophysiological tumor models (μPTMs) are tissue-engineered 3D tumors that are grown in the lab and retain the biological and functional characteristics of the tissue of origin. These μPTMs provide a powerful model of individual patients’ tumor and are used for drug discovery\, cancer research\, and personalized medicine. This talk will discuss various projects related to these models. First\, we will show how radioluminescence microscopy (RLM) can image clinical radionuclides in μPTMs\, providing the equivalent of PET/CT but with higher spatial resolution. By imaging patient-derived organoids\, RLM provides a quantitative endpoint that can be linked to in vivo PET data from the same patient. We will then discuss how RLM can also be applied to “on-chip” tumors\, which are engineered using microfluidics technology to create environmental gradients of oxygen and nutrients\, resulting in heterogeneous physiology. Finally\, we will explore how μPTMs can help decipher the complex biology behind so-called FLASH radiotherapy\, which involves treating tumors with high doses of ionizing radiation in a fraction of a second. By reducing the complexity of animal models while enabling use of patient-derived cells\, μPTMs can reveal crucial biological mechanisms\, yielding biological knowledge that can then be applied to translating these novel treatments. \nBiography \nGuillem Pratx\, PhD is associate professor of Radiation Oncology and Medical Physics at Stanford University. The physical Oncology Lab\, which he leads\, employs physics and math to advance cancer research and patient care. Research projects blend traditional medical physics concepts with recent advances in biomedical engineering to incorporate novel capabilities into current medical imaging and enhance radiation therapy processes. Prof. Pratx is a Damon Runyon Innovator\, an SNMMI Young Investigator\, an NIH investigator\, and the author of over 100 publications. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/guillem-pratx-phd/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/11/Guillem-Pratx-PhD.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250626T120000 DTEND;TZID=America/Los_Angeles:20250626T130000 DTSTAMP:20260513T121947 CREATED:20251121T183744Z LAST-MODIFIED:20251121T183744Z UID:33658-1750939200-1750942800@leadersinlight.com SUMMARY:Prof. C.P.J. Chris Barty DESCRIPTION:Distributed Charge Compton Sources and the Precision Detection and Treatment of Disease\nAbstract \nMedical robotics has been widely applied in areas such as surgical assistance\, enabling higher precision\, reduced fatigue\, and enhanced performance\, and tele-operation\, allowing surgeons to perform procedures remotely without being physically present with the patient. A key enabler of medical robotics is imaging\, which has rapidly evolved over the past two decades to support more minimally invasive\, personalized\, and low-risk diagnostic and therapeutic approaches. My research group focuses on the intersection of medical robotics\, sensing\, and imaging\, with the aim of developing robotic-assisted imaging systems and image-guided robotic interventional platforms. We emphasize ultrasound and photoacoustic (PA) imaging due to their real-time capabilities\, accessibility\, and compact form\, which make them ideal for integration into interventional procedures. In this talk\, I will highlight two major research thrusts in our lab. First\, I will present our work on PA-based functional image-guided interventions\, which provide functional information such as disease states and therapy progression. This approach enables high-sensitivity\, multimodal robotic-assisted surgical guidance. Specifically\, we are investigating the use of molecular-targeted contrast agents to delineate prostate cancer using spectroscopic PA (sPA) imaging\, and a label-free sPA method to monitor therapeutic progression during cardiac ablation. Second\, I will discuss autonomous robotic imaging\, which aims to reduce user dependency during image acquisition\, resulting in higher-quality images and more comprehensive scanning. This includes our development of a robotic optical coherence tomography (OCT) platform for quantifying microstructural parameters of human kidneys during transplant surgeries to assess organ viability\,and an autonomous ultrasound robot for diagnosing lung diseases. These advancements in robotic imaging and intervention have the potential to significantly enhance both diagnostic capabilities and therapeutic outcomes\, paving the way for the next generation of medical imaging and robotics. \nBiography \nProf. C.P.J. (Chris) Barty is a Distinguished Professor of Physics and Astronomy at the University of California\, Irvine (https://faculty.sites.uci.edu/bartylab/). He is also the co-founder of Lumitron Technologies\, Inc of Irvine\, California (www.lumitronxrays.com). At UCI he has affiliations with the Beckman Laser Institute and Medical Clinic\, the Chao Family Comprehensive Cancer Center\, and is the senior member of UCIʼs Convergence Optical Sciences Initiative (COSI). Prior to his arrival in Southern California in 2017\, he had served as the chief technology officer for the $0.5B/annum\, National Ignition Facility and Photon Science Directorate at the Lawrence Livermore National Laboratory. Prof. Barty received his Ph.D. and M.S. in applied physics from Stanford University and B.S.ʼs in chemistry\, physics and chemical engineering\, each with honors\, from North Carolina State University. He is a fellow of OSA\, IEEE\,APS\, SPIE\, and AAAS. Recent recognitions include; the Harold E. Edgerton Award of the SPIE and the R. W. Wood Prize of the OSA. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/chris-barty-6-25/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/11/chrisfinal-192x192-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250501T120000 DTEND;TZID=America/Los_Angeles:20250501T130000 DTSTAMP:20260513T121947 CREATED:20250428T202348Z LAST-MODIFIED:20250428T202348Z UID:33097-1746100800-1746104400@leadersinlight.com SUMMARY:ABRAHAM QAVI\, M.D.\, PH.D. DESCRIPTION:Controlling Light to Reimagine Clinical Diagnostics\nAbstract \nCurrent diagnostic testing faces several challenges\, including limited multiplexing capabilities\, a lack of quantitation information\, the need for centralized laboratories\, and/or cold chain custody.  In this talk\, we highlight the use of photonic resonators and plasmonic enhanced sensors as tools to address these critical gaps in diagnostics.  Both techniques enable the control and manipulation of light to significantly improve the analytical sensitivity and performance of conventional laboratory assays. We demonstrate the use of these technologies for the rapid and sensitive detection of viruses\, including filoviruses and coronaviruses.  We also highlight how optical toolkits can be leveraged to meet urgent global health challenges. \nBiography \nDr. Abraham Qavi completed his undergraduate studies at the University of California\, Irvine\, followed by his PhD and MD at the University of Illinois at Urbana-Champaign.  He subsequently completed medical residency in Clinical Pathology and postdoctoral studies at Washington University in St. Louis.  His research program focuses on the application of photonic resonators and plasmonic enhanced sensing to improve current diagnostic assays.  His clinical obligations include serving as Director of Point of Care Testing\, Director of Innovative Laboratory Diagnostics\, and Associate Director of Clinical Chemistry at UCI Medical Center. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/abraham-qavi/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/04/Screenshot-2025-04-28-132238.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250410T120000 DTEND;TZID=America/Los_Angeles:20250410T130000 DTSTAMP:20260513T121947 CREATED:20250325T193729Z LAST-MODIFIED:20260312T173309Z UID:32897-1744286400-1744290000@leadersinlight.com SUMMARY:Elliot S. Yu\, MD DESCRIPTION:Pitfalls in Clinical Gastroenterology\nAbstract \nGastroenterology is a multi-organ medical specialty pertaining to the treatment of the entire alimentary tract. I would like to introduce biomedical concepts and current treatment and diagnostic modalities of common gastrointestinal disorders and in turn discuss the current limitations of technological and clinical limitations to spark collaboration and ideas for improvement with engineering colleagues who may be interested. Upper endoscopy bleeding\, gastroesophageal reflux disease\, and gastroparesis are areas of the GI foregut where we are still lacking certain tools for early diagnosis\, treatment and understanding of the pathophysiology of these disorders.  \nAs proceduralists\, gastroenterologists practice both medicine and therapeutic endoscopy in our practice. I hope to brainstorm concepts and feasibilities of current wavelength imaging\, proximity sensors and temporal spatial markers to be able to explore these different modalities further and bridge our current gap of knowledge. \nBiography \nDr. Yu earned his medical degree from the State University of New York Jacobs School of Medicine in Buffalo with research honors. He completed a residency in internal medicine and fellowship in Gastroenterology and Hepatology at the Medical College of Wisconsin in Milwaukee. \nAs a physician deeply invested in advancing esophageal care\, Dr. Yu completed an additional year of fellowship research in Neurogastroenterology and Motility at the Medical College of Wisconsin with his clinical training. His work\, including publications and abstracts on the rehabilitative potential of striated esophageal muscles and gastroesophageal reflux disease\, reflects his commitment to advancing care for patients with esophageal conditions through evidence-based practices. Dr. Yu is also interested in investigating novel endoscopic and manometric techniques for diagnosis of esophageal motility disorders and assessment of physiological reflux barriers in the esophagus. He has a clinical focus in dysphagia (difficulty swallowing) and is adept at performing and interpreting esophageal manometry. He also has interest in eosinophilic esophagitis and mechanisms to evaluate and prevent gastroesophageal reflux disease. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/elliot-yu/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/03/Yu-Elliot01-test2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250327T120000 DTEND;TZID=America/Los_Angeles:20250327T130000 DTSTAMP:20260513T121947 CREATED:20250325T192519Z LAST-MODIFIED:20250325T192519Z UID:32892-1743076800-1743080400@leadersinlight.com SUMMARY:Xingde Li\, Ph.D. DESCRIPTION:Low-coherence Biophotonics Imaging for the Brain\nAbstract \nThis talk will highlight our recent efforts in exploring the brain using low-coherence light. We will discuss two scenarios: intraoperative assessment of brain cancer infiltration in patients and real-time imaging of dynamic neural activities in freely behaving rodents. In the first scenario (clinical translation)\, we developed a color-coded quantitative optical coherence tomography (qOCT) technology\, providing neurosurgeons with direct visual cues for maximizing cancer resection while minimizing damage to healthy brain tissue. Our results from over 50 patients demonstrate excellent specificity and sensitivity (>95%). For the second scenario (basic research)\, we created the first all-fiber-optic\, head-mounted\, ultracompact (~2 mm diameter)\, and ultralight ( URL:https://leadersinlight.com/event/xindeli/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Xingde-li-pic.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250226T120000 DTEND;TZID=America/Los_Angeles:20250226T130000 DTSTAMP:20260513T121947 CREATED:20250325T194942Z LAST-MODIFIED:20250325T212420Z UID:32911-1740571200-1740574800@leadersinlight.com SUMMARY:James Rosenzweig\, PhD DESCRIPTION:Relativistic Compton Scattering Experiments: Applications to Science and Medicine\nBiography \nJames Rosenzweig is a Distinguished Professor of Physics in the UCLA Department of Physics and Astronomy specializing in research into advances accelerator\, beam and radiation techniques\, and their frontier applications across science. In pursuit of these goals\, he directs a large research group at UCLA\, the Particle Beam Physics Laboratory (PBPL.) The PBPL concentrates on fundamental aspects of high brightness\, ultra-fast relativistic electron beams\, with application to very high field accelerators based on lasers\, wakefields\, plasmas\, dielectrics and to radiation production\, such as free-electron lasers and Compton scattering sources. \nThis research enables new scientific methods using electron\, terahertz optical and X-ray beams\, which have to applications ranging from high field pumps to study nonequilibrium high field phenomena\, and atomic-molecular level ultra-fast imaging techniques. This research program is based on-campus at the MITHRA advanced accelerator lad and the MOTHRA high field microwave research lab. These state-of-the-art facilities are complemented by a large external program emphasizing wakefield acceleration and at user facilities. Professor Rosenzweig is the author of more than 600 scientific articles and has written a textbook\, Fundamentals of Beam Physics\, emphasizing unity of concepts between charged particle and laser beams. \nDr. Rosenzweig is a lifetime member and Fellow of the American Physical Society. He has been the recipient of Sloan\, SCC and Wilson Fellowships. In recognition of his contributions to his research fields\, he has received the 2007 International Free-electron Laser Prize\, 2022 Advanced Accelerator Prize and the 2023 Alfven Prize in Plasma Physics. Professor Rosenzweig has trained over 35 graduate students\, and these scientists have gone on to key positions in the national labs\, universities\, and industry. He has served five years as the Chair of the UCLA Department of Physics and Astronomy\, and has also co-founded several industrial accelerator companies. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/james-rosenzweig/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-124910-e1742932263664.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250121T120000 DTEND;TZID=America/Los_Angeles:20250121T130000 DTSTAMP:20260513T121947 CREATED:20250325T200206Z LAST-MODIFIED:20250325T212454Z UID:32916-1737460800-1737464400@leadersinlight.com SUMMARY:Vasilis Ntziachristos\, M.Sc.\, Ph.D. DESCRIPTION:From Optical to Optoacoustic Imaging: Technology Advances and Clinical Translation\nAbstract \nBiological discovery is a driving force of biomedical progress. With rapidly advancing technology to collect and analyze information from cells and tissues\, we generate biomedical knowledge at rates never before attainable to science. Nevertheless\, conversion of this knowledge to patient benefits remains a slow process. To accelerate the process of\nreaching solutions for healthcare\, it would be important to strongly complement this culture of discovery with a culture of problem-solving in healthcare. \nThe talk focuses on recent progress with optical and optoacoustic technologies\, including Multispectral Optoacoustic Tomography (MSOT) and Raster-scan Optoacoustic Mesoscopy (RSOM)\, as well as computational methods\, as the means to opening new paths for solutions in biology and medicine. Particular attention is given on the use of these\ntechnologies for early detection and monitoring of disease evolution. The talk further shows new classes of imaging systems and sensors for assessing biochemical and pathophysiological parameters of systemic diseases\, complement knowledge from –omic analytics and drive integrated solutions for improving healthcare. \nBiography \nProfessor Vasilis Ntziachristos studied electrical engineering at Aristotle University in Thessaloniki. Following his M.Sc. and Ph.D. in the Department of Bioengineering at the University of Pennsylvania\, he was then appointed Assistant Professor and Director of the Laboratory for Bio-Optics and Molecular Imaging at Harvard University and Massachusetts General Hospital. \nSince 2007\, he has served as Professor of Medicine and Electrical Engineering and the Chair of Biological Imaging at the Technical University of Munich and Director of the Institute of Biological and Medical Imaging at Helmholtz Munich. Prof. Ntziachristos is also currently Director of Bioengineering at the Helmholtz Pioneer Campus\, the Head of the Bioengineering Department at Helmholtz Munich\, and Director of the IESL at FORTH. Prof. Ntziachristos is the founder of the journal Photoacoustics\, regularly Chairs in international meetings and councils and has received numerous awards and distinctions\, including the Karl Heinz Beckurts prize (2021)\, the Chaire Blaise Pascal (2019) from the Region Ile-de-France\, the Gold Medal from the Society for Molecular Imaging (2015)\, the Gottfried Leibnitz prize from the German Research Foundation (2013)\, the Erwin Schrödinger Award (2012) and was named one of the world’s top innovators by the Massachusetts Institute of Technology (MIT) Technology Review in 2004. In 2024\, he has been elected as a new member of the German Academy of Sciences Leopoldina. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/vasilis-ntziachristos/ LOCATION:BLI Library CATEGORIES:2025 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/03/Professor-Vasilis-Ntziachristos2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241202T120000 DTEND;TZID=America/Los_Angeles:20241202T130000 DTSTAMP:20260513T121947 CREATED:20241114T223343Z LAST-MODIFIED:20241114T223343Z UID:32569-1733140800-1733144400@leadersinlight.com SUMMARY:Lingyan Shi DESCRIPTION:Multimodal Metabolic Nanoscopy for Studying Aging and Related Diseases\nAbstract \nUnderstanding how metabolism functions in multicellular organisms is essential for revealing the fundamental mechanisms of numerous biological processes. Metabolism involves the creation\, transformation\, and breakdown of biomolecules\, acting according to genetic instructions. Traditional imaging techniques like MRI\, PET\, fluorescence\, and mass spectrometry come with limitations. In contrast\, stimulated Raman scattering (SRS)\, a non-linear vibrational imaging microscopy technique\, offers chemically specific images with high resolution\, deep penetration\, and the ability to quantify. Our research has developed and combined deuterium-probed picosecond stimulated Raman scattering (DO SRS)\, multiphoton fluorescence (MPF)\, and second harmonic generation (SHG) into a unified nanoscopy. This tool is designed for studying metabolic changes in aging and diseases. The process of enzymatic incorporation of deuterium generates carbon-deuterium (C-D) bonds in newly formed molecules\, detectable by DO-SRS within the spectral cell silence region of the Raman spectrum\, which identifies them apart from older molecules.  \nOne significant finding is that lipid turnover decreases faster in aged female Drosophila compared to males. Additionally\, dietary restrictions\, downregulation of the insulin/IGF-1 signaling (IIS) pathway\, and AMPK activation significantly alter lipid metabolism in aged or Alzheimer’s-affected brains. The introduction of APoD and PRM algorithms has enhanced our current multimodal metabolic nanoscopy to deliver superresolution with hyperspectral volumetric imaging capabilities. By using deuterated molecules—including glucose\, amino acids\, fatty acids\, and water molecules—as bioorthogonal probes\, this technology provides insights into the metabolic heterogeneity of organs such as the brain\, adipose tissue\, liver\, muscle\, retina\, and kidneys.  \nBiography \nLingyan Shi is currently an Associate Professor in the Shu Chien Gene Lay Department of Bioengineering at UCSD. She joined UCSD in 2019\, following her postdoctoral training in the Department of Chemistry at Columbia University. Her lab at UCSD focuses on developing high-resolution metabolic nanoscopy to study aging processes and related diseases. Notably\, she discovered the “Golden Window” for deep tissue imaging and pioneered the “DO-SRS” metabolic imaging platform\, which visualizes metabolic dynamics in cells and tissues. At UC San Diego\, her group further advanced stimulated Raman scattering (SRS) microscopy into super-resolution multiplex nanoscopy by developing A-PoD and PRM algorithms\, revealing various lipid metabolic changes in organ tissues during aging and disease.  \nDr. Shi holds 10 awarded patents and 8 pending. She won Blavatnik Regional Award for Young Scientists (2018)\, Nature Light Science & Applications’ Rising Star Award (2021)\, the Advancing Bioimaging Scialog Fellow Award 2023\, the David L. Williams Lecture Scholarship Award (2023)\, the Sloan Research Fellowship in Chemistry (2023)\, the BMES Cellular Molecular Bioengineering Rising Star Faculty Award (2024)\, the Davos Summit iCANx Young Scientist Award (2024)\, and Featured in the 2025 Global Woman in Optics notebook.  \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/lingyan-shi/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2024/11/Screenshot-2024-11-14-143054.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241114T120000 DTEND;TZID=America/Los_Angeles:20241114T130000 DTSTAMP:20260513T121947 CREATED:20241023T194620Z LAST-MODIFIED:20241023T194642Z UID:32465-1731585600-1731589200@leadersinlight.com SUMMARY:Shu Jia DESCRIPTION:Toward High-Speed Light-Field Biophotonics\nAbstract \nVisualizing the diverse anatomical and functional traits within the densely packed cellular space and over large heterogeneous populations unfolds critical details of the fundamentals of living organisms. In this talk\, I will present my laboratory’s recently developed advanced microscopy techniques for high-throughput extraction of molecular information in cells and tissues with ultrahigh-spatiotemporal resolution and accessibility. \nBiography \nDr. Shu Jia is an Associate Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. He received his BS at Tsinghua University\, Ph.D. with Professor Jason Fleischer at Princeton University\, and postdoctoral training with Professor Xiaowei Zhuang at Harvard University. Dr. Jia is a recipient of the NSF CAREER Award\, DARPA Young Faculty Award and NIH MIRA Award among others. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/shu-jia/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2024/10/shu-jia.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241010T120000 DTEND;TZID=America/Los_Angeles:20241010T130000 DTSTAMP:20260513T121947 CREATED:20241023T185821Z LAST-MODIFIED:20241023T185821Z UID:32461-1728561600-1728565200@leadersinlight.com SUMMARY:Christine O'Brien DESCRIPTION:Development of wearable laser speckle imaging devices for use at the point-of-care\nAbstract \nWhile laser speckle contrast imaging (LSCI) was historically confined to bulky benchtop systems\, research teams have recently developed hand-held and wearable laser speckle systems. For these systems to be useful in a clinical setting\, hand-held devices must be lightweight and compact enough to easily lift and move around while wearable users must be able to function normally. This requires careful selection and characterization of camera and laser components; for untethered systems\, this requires small and inexpensive computation and battery modules\, and intentional hardware design. A wearable and wireless LSCI device that uses a two-lens design will be presented and point-of-care design considerations and tradeoffs will be discussed. \n  \nIn vitro and in vivo validation studies in phantoms\, swine\, and human subjects will demonstrate the sensitivity of the device to small blood flow changes and numerous physiologic applications for the technology will be discussed. Additionally\, a patient-specific normalization strategy that provides insights on severity of peripheral vasoconstriction and skin pigmentation correction will be presented. \nBiography \nChristine O’Brien is an Assistant Professor of Biomedical Engineering at Washington University in St. Louis with a secondary appointment in the department of Obstetrics & Gynecology. Her research is focused on developing and translating non-invasive optical spectroscopy and imaging tools to solve global problems in maternal-fetal health. Dr. O’Brien obtained her PhD in Biomedical Engineering at Vanderbilt University and completed postdoctoral training at Washington University School of Medicine in the Department of Radiology. She launched her independent research program with projects focused on the development of novel wearable sensors for the early detection of postpartum hemorrhage and novel strategies for preterm birth detection and investigation. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/christine-obrien/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2024/10/christine-o-brien-headshot.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240906T110000 DTEND;TZID=America/Los_Angeles:20240906T120000 DTSTAMP:20260513T121947 CREATED:20240829T180705Z LAST-MODIFIED:20240829T181435Z UID:32202-1725620400-1725624000@leadersinlight.com SUMMARY:Eduardo Juárez\, Ph.D. DESCRIPTION:Hyperspectral Image and Video Processing in Neurosurgery: the HELICoiD\, NEMESIS-3D-CM\, and STRATUM Research Projects \nAbstract \nBrain tumor surgery is one of the most complex procedures that benefits from integrated digital diagnostics. Differentiating pathological tissue margins and interpreting multimodal data from a variety of independent devices are among the main challenges neurosurgeons face during brain tumor resections. In this seminar\, the main results of several European and Spanish research projects\, such as HELICoiD\, NEMESIS-3D-CM\, and STRATUM\, in which the Research Center on Software Technologies and Multimedia Systems (CITSEM) at the Universidad Politécnica de Madrid (UPM) has been involved\, will be reviewed. Over the past few years\, these projects have contributed to partially overcoming these challenges by developing solutions for brain surgery guidance and diagnostics based on multimodal data processing. Our long-term research goal is to increase the intraoperative diagnostic accuracy of brain tumor operations\, with the hope of eventually extending these results to support surgeries in other anatomical areas. \nBiography \nEduardo Juárez is currently an Associate Professor in the Telematics and Electronics Engineering Department at the Universidad Politécnica de Madrid (UPM)\, Spain\, and Vice-Director of the UPM Research Center on Software Technologies and Multimedia Systems (CITSEM)\, where he conducts his research. He holds a PhD from the École Polytechnique Fédérale de Lausanne (EPFL\, 2003)\, Switzerland. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/eduardo-juarez-ph-d/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2024/08/Eduardo-Juarez-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240627T120000 DTEND;TZID=America/Los_Angeles:20240627T130000 DTSTAMP:20260513T121947 CREATED:20250325T213637Z LAST-MODIFIED:20250325T213637Z UID:32979-1719489600-1719493200@leadersinlight.com SUMMARY:Alberto Martín-Pérez DESCRIPTION:Advancing In-Vivo Human Brain Tissue Classification: A Multimodal Approach Integrating Machine Learning\, Hyperspectral Imaging and Depth Information\nAbstract \nThis talk will present a novel approach to classify in vivo human brain tissue in real time using a multimodal imaging technique that integrates hyperspectral imaging and depth information in a recently developed system called Slim Brain. This system has been used during surgical procedures to collect a database of over 193 patients that is growing weekly. By applying sophisticated machine learning algorithms to the acquired information\, Slim Brain demonstrates the potential of combining advanced imaging modalities with computational techniques for precise and non-invasive assessment of brain tissue\, with implications for neurology and medical imaging. In addition\, a new acquisition system under development that combines hyperspectral imaging with spatial frequency domain imaging modulation will be presented as a new tool to improve brain tissue classification. \nBiography \nAlberto Martín-Pérez is a Teaching Assistant at the Department of Audivisual Engineering and Communication in the School of Telecommunications Systems and Engineering of the Technical University of Madrid (UPM). Presently\, he is pursuing a PhD at UPM with the Electronic and Microelectronic Design Group (GDEM) in the Research Center on Software Technologies and Multimedia Systems for Sustainability (CITSEM). His research pursuits center around the utilization of Machine Learning algorithms for the classification of in-vivo human brain tumors through hyperspectral imaging. Furthermore\, he aims to enhance classification methodologies through the application of spatial frequency domain imaging for his doctoral studies. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/alberto-martin-perez/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-143611.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240614T120000 DTEND;TZID=America/Los_Angeles:20240614T130000 DTSTAMP:20260513T121947 CREATED:20250325T213245Z LAST-MODIFIED:20250325T213245Z UID:32971-1718366400-1718370000@leadersinlight.com SUMMARY:Kamran Avanaki\, Ph.D. DESCRIPTION:Biomedical hyperspectral imaging of murine tumors in the preclinical environment\nAbstract \nIn this talk\, we explore the application of optical coherence tomography (OCT) in skin imaging and various applications of photoacoustic imaging in brain imaging. For skin imaging\, we introduce a novel image analysis method to assess tissue health. This algorithm extracts optical radiomic signatures from OCT images\, providing detailed insights into tissue characteristics. In the realm of brain imaging\, we discuss the use of photoacoustic microscopy for vascular and functional imaging in small animals\, addressing significant neuroscientific questions. Additionally\, we highlight the application of photoacoustic tomography in large animal brain imaging\, emphasizing its potential translation to clinical settings. \nOne significant finding is that lipid turnover decreases faster in aged female Drosophila compared to males. Additionally\, dietary restrictions\, downregulation of the insulin/IGF-1 signaling (IIS) pathway\, and AMPK activation significantly alter lipid metabolism in aged or Alzheimer’s-affected brains. The introduction of APoD and PRM algorithms has enhanced our current multimodal metabolic nanoscopy to deliver superresolution with hyperspectral volumetric imaging capabilities. By using deuterated molecules—including glucose\, amino acids\, fatty acids\, and water molecules—as bioorthogonal probes\, this technology provides insights into the metabolic heterogeneity of organs such as the brain\, adipose tissue\, liver\, muscle\, retina\, and kidneys.  \nBiography \nTadej Dr. Kamran Avanaki is an Associate Professor of Biomedical Engineering Department at the University of Illinois in Chicago. Prior to this position he was an Associate Professor of Biomedical Engineering Department at Wayne State University. His areas of expertise include\, design and development of photoacoustic imaging technology and optical coherence tomography for biomedical applications to solve critical problems in brain and skin imaging. He completed his postdoctoral-fellowship at Washington University in St. Louis in 2012 under Professor Lihong Wang\, a pioneer in photoacoustic technology. He has a Ph.D. from the University of Kent with outstanding postgraduate student honors where he was mentored by Professor Adrian Podoleanu\, the world’s leader in OCT instrumentation. As principal investigator\, he has received multiple research grants/ fellowships. He is credited with more than 120 published first-authored/senior-authored peer-reviewed articles in high-impact journals such as\, PNAS\, Cancer Research\, IEEE Transaction of Medical Imaging\, Photoacoustics\, and Theragnostic. He currently serves as an associate editor of Biomedical Optics Express and Scientific Report. He has received the Outstanding Faculty Award from the College of Engineering at Wayne State University\, in 2016\, 2017\, and 2019\, also the Research Excellence Award in 2019 as well as the Excellence in Teaching Award in 2019. He has also received the prestigious 2020 Wayne State University Academy of Scholar Award\, and most recently 2023 Rising Star Award and Excellence in Teaching Award from the University of Illinois at Chicago. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/kamran_avanaki_phd/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/03/kamran-Avanaki.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240606T120000 DTEND;TZID=America/Los_Angeles:20240606T130000 DTSTAMP:20260513T121947 CREATED:20250325T212515Z LAST-MODIFIED:20250325T212515Z UID:32963-1717675200-1717678800@leadersinlight.com SUMMARY:Tadej Tomanic\, MSc DESCRIPTION:Biomedical hyperspectral imaging of murine tumors in the preclinical environment\nAbstract \nBiomedical hyperspectral imaging (HSI) is an emerging non-invasive optical imaging technique that captures spatial and spectral information of the imaged biological tissue. In recent years\, HSI has been widely used to image human and animal tumors in the brain\, breast\, colon\, prostate\, and skin. This talk will cover the recent advancements in hyperspectral imaging for biomedical applications\, mainly skin\, in our lab at the Faculty of Mathematics and Physics\, University of Ljubljana\, Ljubljana\, Slovenia. The talk will introduce the basics of HSI and various implementations\, followed by presenting tissue models and algorithms needed to extract tissue properties from hyperspectral images\, focusing on the inverse adding-doubling (IAD) algorithm and advanced machine learning (ML) techniques. Moreover\, the application of HSI to monitor the growth of different murine tumor models in the preclinical setting will be presented\, and the possibility of combining HSI with other optical techniques\, such as laser speckle contrast imaging\, will be demonstrated. Ultimately\, the capabilities of HSI for early detection of murine tumors will be exhibited. \n. \nOne significant finding is that lipid turnover decreases faster in aged female Drosophila compared to males. Additionally\, dietary restrictions\, downregulation of the insulin/IGF-1 signaling (IIS) pathway\, and AMPK activation significantly alter lipid metabolism in aged or Alzheimer’s-affected brains. The introduction of APoD and PRM algorithms has enhanced our current multimodal metabolic nanoscopy to deliver superresolution with hyperspectral volumetric imaging capabilities. By using deuterated molecules—including glucose\, amino acids\, fatty acids\, and water molecules—as bioorthogonal probes\, this technology provides insights into the metabolic heterogeneity of organs such as the brain\, adipose tissue\, liver\, muscle\, retina\, and kidneys.  \nBiography \nTadej Tomanic\, MSc\, is a young researcher and teaching assistant at the Faculty of Mathematics and Physics\, University of Ljubljana\, Ljubljana\, Slovenia. He received his BSc and MSc degrees in Physics and Medical Physics from the University of Ljubljana in 2017 and 2020\, respectively. As part of his Master’s research\, he collaborated with the Department of Neurology\, University Medical Centre Ljubljana\, to analyze brain FDG PET images of patients with Alzheimer’s disease. He also interned at Cosylab as a software engineer to work on developing a treatment planning system for patients with cancer treated with radiotherapy. He is currently pursuing his PhD in Physics at the University of Ljubljana under the supervision of Assoc. Prof. Matija Milanic\, PhD. His research interests include early tumor detection\, monitoring\, treatment\, and tumor vasculature development in vivo. He develops and applies various optical imaging methods in preclinical and clinical environments\, focusing on hyperspectral imaging\, laser speckle contrast imaging\, optical coherence tomography\, and optical profilometry. He is expected to graduate by January 2025. \n \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/tadej_tomanic_msc/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2025/03/Tadej.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240208T120000 DTEND;TZID=America/Los_Angeles:20240208T130000 DTSTAMP:20260513T121947 CREATED:20250325T213048Z LAST-MODIFIED:20250325T213048Z UID:32970-1707393600-1707397200@leadersinlight.com SUMMARY:Inga Saknite\, Ph.D. DESCRIPTION:Smartphone-based total body photography of patients with mpox in remote areas of the Democratic Republic of the Congo\nAbstract \nMpox (associated with clade I monkeypox virus infection) is endemic in the Democratic Republic of the Congo (DRC) and manifests with hundreds to thousands of total body lesions and an estimated case fatality ratio of 11% (17% in children). In October 2022\, the PALM007 randomized placebo-controlled clinical trial of the safety and efficacy of tecovirimat for mpox was launched at remote sites in the DRC. Time to lesion resolution is the primary study endpoint\, making frequent lesion count assessments a critical study measure. Given the typically very high burden of skin lesions\, daily counting poses considerable human resource challenges to clinicians and clinical research staff. \nWe have established smartphone-based protocols for standardized total body photography to document mpox lesion appearance\, evolution\, and resolution. We will share our experience setting up\, standardizing\, and overseeing photodocumentation of mpox in remote trial sites\, discussing technical\, educational\, and cultural considerations. This rich standardized dataset of clade I mpox images will enable the development of artificial intelligence (AI) tools aimed to automate mpox lesion counting in future studies. Further\, new optical technologies may be advanced in response to this clinical need. Smartphone-based photodocumentation coupled with AI image analysis has become a benchmark for evaluating the performance of novel optical technologies. The PALM007 trial is supported by the Institut National de la Recherche Biomédicale (INRB) of the DRC and the National Institute of Allergy and Infectious Diseases (NIAID) of the US\, and funded by NCI Contract No.75N910D00024\, Task Order No.75N91020F00025. \nBiography \nDr. Inga Saknite is a Leading Researcher at the Biophotonics Laboratory\, the University of Latvia\, and an Adjoint Assistant Professor in Dermatology at the Vanderbilt University Medical Center in Nashville\, Tennessee\, the United States. Her main research interest is advancing noninvasive imaging technologies to quantitatively assess skin for clinical impact. Among other projects\, Dr. Saknite is currently leading photodocumentation of patients with mpox as part of a randomized controlled trial in the Democratic Republic of the Congo. She has multiple years of research experience in photographic\, hyperspectral\, and microscopic imaging of human skin\, standardized protocol and guideline development\, image processing and analysis\, and device and algorithm development. \nDr. Saknite received her PhD in physics from the University of Latvia in 2016. She was then awarded the Fulbright Scholarship to advance her translational research career at the Beckman Laser Institute of the University of California\, Irvine. From 2017 until 2021\, Dr. Saknite was a Postdoctoral Research Fellow at the Vanderbilt Dermatology Translational Research Clinic (VDTRC.org)\, and was named the inaugural Vanderbilt Postdoctoral Mentor of the Year in 2021. She has received several additional awards\, including the Abstract Achievement Award at the Annual Meeting of the American Society of Hematology and the best talk award at the Annual Vanderbilt Postdoctoral Association Symposium. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/inga-saknite-2/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-143017.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240201T120000 DTEND;TZID=America/Los_Angeles:20240201T130000 DTSTAMP:20260513T121947 CREATED:20250325T210232Z LAST-MODIFIED:20250325T214945Z UID:32945-1706788800-1706792400@leadersinlight.com SUMMARY:Keiichiro Kagawa\, Ph.D. Eng. DESCRIPTION:Enhancing SFDI’s functionality and performance with state-of-the-art CMOS image sensors\nAbstract \nRecently\, new CMOS image sensors with high performance and functionalities such as near-infrared-enhanced global shutter\, multi-tap pixels for time-division-multiplexing (TDM) or time-resolved (TR) imaging\, and multi-aperture (MA) are emerging. At Shizuoka University\, TDM\, TR\, and MA CMOS image sensors are being developed for LiDAR and biomedical imaging applications. In my talk\, examples of SFDI systems with enhanced functionality and performance are shown. (1) multi-wavelength SFDI with suppression of ambient light bias and motion artifacts\, (2) fusion of SFDI and near-infrared spectroscopy (NIRS) using scanned multiple lines\, (3) fusion of SFDI and time-resolved imaging. \nBiography \nKeiichiro Kagawa received the Ph.D. degree in engineering from Osaka University\, Osaka\, Japan\, in 2001. In 2001\, he joined Graduate School of Materials Science\, Nara Institute of\nScience and Technology as an Assistant Professor. In 2007\, he joined Graduate School of Information Science\, Osaka University as an Associate Professor. In 2011\, he joined Shizuoka University as an Associate Professor. Since 2020\, he has been a Professor with Shizuoka University\, Hamamatsu\, Japan. His research interests cover high-performance computational CMOS image sensors\, imaging systems\, and biomedical applications. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/keiichiro-kagawa/ LOCATION:BLI Library CATEGORIES:2024 Hybrid Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-140153.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20231121T120000 DTEND;TZID=America/Los_Angeles:20231121T130000 DTSTAMP:20260513T121947 CREATED:20250325T212039Z LAST-MODIFIED:20250325T212039Z UID:32952-1700568000-1700571600@leadersinlight.com SUMMARY:Xunbin Wei\, Ph.D. DESCRIPTION:Light Treatment of Alzheimer’s Disease\nAbstract \nPhotobiomodulation\, by utilizing low-power light in the visible or near-infrared spectrum to trigger biological responses in cells and tissues\, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD)\, while its specific mechanisms have remained elusive. Here\, we provide evidence that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden\, the hallmark of AD. The glial cells\, including microglia and astrocytes\, play important roles in Aβ clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with Aβ are sufficient to reduce Aβ load in AD mice. \nMoreover\, we demonstrate that 1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further improve Aβ clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic\napproach for AD. \nBiography \nDr. Wei received his bachelor in physics from University of Science and Technology of China\, Hefei. He received his PhD from Department of Physiology and Biophysics\, University of California\, Irvine. Dr. Wei completed his post-doc training at Children’s Hospital\, Harvard Medical School. From 2006-2010\, he was a professor in Fudan University\, China. From 2006-2010\, he was a professor and chair in Department of Biomedical Instrumentation\, School of Biomedical Engineering\, Shanghai Jiao Tong University\, China. \nCurrently\, he is a professor at Department of Biomedical Engineering\, Peking University. Dr. Wei is an SPIE Fellow\, and recipient of Chinese Outstanding Young Scholar Award. He has published more than 120 peer-reviewed papers\, including in Nature and PNAS. His research interests include cancer detection by optical means\, optical manipulation of cells\, and light treatment of Alzheimer disease. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/xunbin-wei/ LOCATION:BLI Library CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-141956.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230615T120000 DTEND;TZID=America/Los_Angeles:20230615T130000 DTSTAMP:20260513T121947 CREATED:20250325T204318Z LAST-MODIFIED:20250325T204318Z UID:32933-1686830400-1686834000@leadersinlight.com SUMMARY:Hyunmo Yang\, Ph.D. DESCRIPTION:Deep Learning Applications in Biomedical Imaging\nAbstract \nRecently developed deep learning techniques revolutionized image analysis methods in the last decade. Classification\, segmentation\, quantitative prediction\, and generating new data can be performed by the training of deep learning models. These tasks can directly be applied to biomedical imaging and successful applications will provide strong advantages to researchers and physicians in terms of efficiency for their studies and improvement in diagnosis. \nIn this talk\, I will discuss my recent studies that using deep learning techniques to the following topics: glaucoma screening from fundus photographs based on regional retinal nerve fiber layer (RNFL) thickness estimation using deep learning\, label-free digital histopathology with QPI imaging based on virtual staining and image classification techniques\, and high-throughput phenotype screening platform using office scanner. For these studies\, we have employed the convolution neural network (CNN) network architectures and trained them to perform image-to-number regression\, image classification\, image segmentation\, and image-to-image generation. The details of each approach will be also discussed. \nBiography \nDr. Hyunmo Yang earned his Ph.D. in physics from Ulsan National Institute of Science of Technology (UNIST) in Korea. After his degree in 2019\, he joined as a postdoc researcher to the translational biophotonics laboratory in department of biomedical engineering at UNIST. He is currently working on developing machine learning and deep learning applications for biomedical imaging. His research interests are digital medicine\, digital screening and digital histopathology using A.I. technology. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/hyunmo-yang/ LOCATION:BLI Library CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-134139-1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230427T120000 DTEND;TZID=America/Los_Angeles:20230427T130000 DTSTAMP:20260513T121947 CREATED:20250325T203342Z LAST-MODIFIED:20250325T204503Z UID:32928-1682596800-1682600400@leadersinlight.com SUMMARY:Roukuya Mamuti\, Ph.D. DESCRIPTION:Tunable infrared structured laser generation and opto-thermal trapping of micro/nano particles\nAbstract \nThis talk covers the experimental research and theoretical investigation of mid-infrared tunable optical vortex sources with versatile orbital angular momentum (OAM) and opto-thermophoretic trapping of micro and nano particles with mid-infrared fiber lasers. As a typical structured light\, optical vortex with a helical wavefront exhibits interesting physical properties\, including an annular spatial intensity profile and an OAM of owing to an on-axial phase singularity. Such properties of the vortex beam have been widely utilized in diverse applications. In the talk\, Dr. Mamuti presents generation of optical vortices with versatile OAM states from a nanosecond optical parametric oscillator (OPO) by appropriately shortening or extending the cavity. The system with a compact cavity configuration enables the production of a millijoule-level signal (idler) output with l =1~3 (0~-2) simply by tuning the wavelength of signal output. The system was further developed to create coherently coupled OAM states\, i.e.\, flower-shaped signal and wheel-shaped idler outputs\, arising from the coherent superposition of opposite-signed OAM states. \nFurthermore\, Dr. Mamuti proposed a method for opto-thermophoretic trapping with a 2 μm Tm-doped fiber laser. The infrared continuous-wave laser beam is directly and strongly absorbed by water solution\, and some local temperature gradient is generated around the focus. The particles are migrated along the temperature gradient and form a hexagonal close-packed structure at a bottom-glass solution interface. She has investigated the dependence of the phenomenon on the material\, particle size\, and laser power. Since the water molecules have a significant absorption in the 3-μm wavelength band\, a midinfrared Er:ZBLAN tunable fiber laser is applied for opto-thermophoretic trapping of particles diffusing in water. Through the laser wavelength dependence and single particle tracking analysis\, they found that particles are rapidly collected at the laser focus which is much faster than near infrared lasers. The system with 2 μm and 3 μm direct optothermal trapping could be extended in various fields\, such as bio sensing\, detection\, and sorting. \nBiography \nDr. Roukuya Mamuti received her Master’s and Ph.D. degrees in Optical Engineering from laser laboratory\, Chiba University\, Japan. Her graduate research mainly focused on the generation of tunable infrared structured lasers. After graduation\, she worked as a postdoctoral researcher at Laser Lab (the same lab where she earned her degree). Dr. Mamuti received 2 million Japanese yen of research grant from Kambayashi foundation (private funding). Later\, she worked in the Laser Science Laboratory at Toyota Technological Institute\, to develop optical trapping of micro/nano particles. Now\, she is seeking a research position to pursue her profession in laser-related research fields. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n  URL:https://leadersinlight.com/event/roukuya-mamuti/ LOCATION:BLI Library CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-133315.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230316T120000 DTEND;TZID=America/Los_Angeles:20230316T130000 DTSTAMP:20260513T121947 CREATED:20230314T184923Z LAST-MODIFIED:20230314T184923Z UID:31214-1678968000-1678971600@leadersinlight.com SUMMARY:Mehmet Cilingiroglu\, MD\, FSCAI\, FACC\, FESC DESCRIPTION:Cardio-oncology; Cardiovascular diseases in cancer patients \nAbstract \nWith more advances in cancer therapy\, more patients are alive as cancer survivors than a decade ago.\nHowever\, cardiovascular disease is the number one reason for mortality in these cancer free patients.\nBeside the conventional risk factors for cardiovascular diseases\, radiation and chemotherapy and\ncancer specific immunotherapy contributes to increased risk. We will discuss the details of\ncardiovascular disease etiologies and treatment options in this specific patient population. \nBiography \nDr. Cilingiroglu is a well-established interventional cardiologist and structural heart interventionalist.\nHe has academic affiliations with several different universities in the USA as well as in EU for various\nresearch and educational collaborations. Beside providing excellent clinical cardiovascular care\, over\nthe last two decades he has been involved and lead many different investigator initiated and novel\ndevice development studies. Have been collaborating with Professor Milner and his team for many\nyears. \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/mehmet-cilingiroglu/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/Mehmet.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230207T120000 DTEND;TZID=America/Los_Angeles:20230207T130000 DTSTAMP:20260513T121947 CREATED:20230314T184214Z LAST-MODIFIED:20230314T184214Z UID:31208-1675771200-1675774800@leadersinlight.com SUMMARY:Jiawen Li\, Ph.D. DESCRIPTION:Ultrathin 3D-printed Imaging Devices \nAbstract \nPreclinical studies and clinical diagnostics increasingly rely on optical techniques to visualize internal\norgans. Miniaturised catheters or endoscopes are necessary for imaging small and/or delicate\narteries. However\, current lens fabrication methods limit the performance of these ultrathin devices\,\nresulting in a poor combination of resolution\, depth of focus and multimodal imaging capability.\nThis talk will introduce her latest research to address these combined challenges. In particular\, she\nhas utilized 3D micro-printing technology to fabricate lenses\, with a diameter of less than 350 μm\,\ndirectly onto an optical fiber to achieve freeform designs for 1) aberration-corrected optical coherence\ntomography (OCT)\, 2) Bessel beam OCT\, and 3) highly-sensitive multimodal fluorescence+OCT\nimaging in vivo. \nBiography \nDr. Jiawen Li is a Fellow of L’Oréal-UNESCO\, National Heart Foundation and NHMRC\, and a Senior\nLecturer at the School of Electrical and Electronic Engineering\, the University of Adelaide. She received\nher Bachelor’s degree in Optical Engineering from Zhejiang University (China) in 2010\, and her PhD\ndegree in Biomedical Engineering from the University of California\, Irvine (USA) in 2015.\nSince finishing her PhD\, Dr. Li has secured >$2 million research funding as the lead chief/principal\ninvestigator and won numerous prestigious awards/honours (including national Superstar of STEM\,\nAustralian and New Zealand Optical Society Geoff Opat Early Career Researcher Prize\, Heart\nFoundation Paul Korner Innovation Award\, Young Tall Poppy Science Award\, etc.). Dr Li’s research\nfocuses on multimodal imaging\, ultrathin endoscopes\, optical sensing\, 3D micro-printing\, and optical\ncoherence tomography. \n\n  URL:https://leadersinlight.com/event/jiawen-li-ph-d/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/Jiawen2.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230126T120000 DTEND;TZID=America/Los_Angeles:20230126T130000 DTSTAMP:20260513T121947 CREATED:20230314T183414Z LAST-MODIFIED:20230314T183414Z UID:31203-1674734400-1674738000@leadersinlight.com SUMMARY:Yun Jing\, PhD DESCRIPTION:Numerical Modeling of Medical Ultrasound \nAbstract \nIn the last two decades\, we have witnessed substantial development in high intensity focused ultrasound (HIFU) for treating a\nbroad spectrum of diseases and medical conditions. As a non invasive surgical modality that can reach deep tissue\, HIFU has\nthe potential to revolutionize therapy. Although there are many numerical models available\, none can currently achieve both\nefficient and sufficiently accurate simulations for acoustic wave propagation in large scale\, heterogeneous biological media.\nExisting numerical models face two enduring dilemmas: they are either very efficient but not accurate due to invalid\napproximations\, or they are very accurate but computationally time consuming and therefore impractical in many cases. I will\ndiscuss our effort throughout the past 10 years in developing new numerical models for HIFU\, that aims to establish a\nbalance between accuracy and computational efficiency. I will focus on both the theoretical development and the practical\napplications of the numerical algorithm. I will also introduce our NIH funded project that aims to develop an open source\ntoolbox for modeling medical ultrasound (https://m-sound.github.io/mSOUND/home). \nBiography \nYun Jing\, Ph.D. was a research fellow at Brigham and Women’s Hospital\, and an assistant professor and associate professor\nat North Carolina State University\, prior to joining the Graduate Program in Acoustics at Penn State University in 2020.\nDr. Jing has published over 85 peer reviewed scientific manuscripts. Dr. Jing is fellow of ASA\, a senior member of IEEE\,\nand an associate editor of the Journal of the Acoustical Society of America and Frontiers in Materials. He has received\nnumerous awards such as the 2018 R. Bruce Lindsay Award from the Acoustical Society of America\, the 2018 IEEE\nUltrasonics Early Career Investigator award\, 2018 MIT Technology Review Innovator under 35 China award\, and the\nIEEE UFFC Star Ambassador Lectureship Award. Dr. Jing earned his B.S. in acoustics from Nanjing University\, China\,\nM.S.\, and Ph.D. in architectural acoustics from Rensselaer Polytechnic Institute. \n  URL:https://leadersinlight.com/event/yun-jing-phd/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/03/jing.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230112T120000 DTEND;TZID=America/Los_Angeles:20230112T130000 DTSTAMP:20260513T121947 CREATED:20230109T213645Z LAST-MODIFIED:20230109T213950Z UID:31131-1673524800-1673528400@leadersinlight.com SUMMARY:Lilit Garibyan\, MD\, PhD\, FAAD DESCRIPTION:A Leadership Toolbox for Operationalizing Innovation at Your Institution \nAbstract \nIn today’s challenging healthcare environment\, the importance of innovation has never been greater. Every healthcare institution anduniversity strive to be innovative\, but successful innovative cultures and programs are difficult to create and sustain especially in the busy and fast-paced healthcare settings. Creating an innovative culture requires having a structured process and framework that educates\, trains and rewards individuals who engage in innovation. \nThe “Magic Wand Initiative” was created at Massachusetts General Hospital to empowers and engages healthcare professional in problembased innovation. It is designed to bring innovation directly to clinicians\, reduce the barriers to engagement and provide necessary resourcesm for clinicial and research faculty to work collaboratively to solve unmet needs and generate outcomes. Over the last several years I have lectured about this revolutionary and impactful national and international curriculum called the “Magic Wand Initiative and Virtual Magic Wand program” http://www.magicwandinitiative.org/ to teach leaders and clinicians how to leverage innovation for outcomes. In this talk we will aim to:\n• Describe the importance of innovation in healthcare\n• Identify common barriers to innovation\n• Develop strategies that individuals and institutions can use to implement innovation \n  \nBiography \nDr. Lilit Garibyan MD\, PhD is a physician-scientist at Wellman Center for Photomedicine\, board certified dermatologist and faculty member at Harvard Medical School Department of Dermatology. She is listed as an inventor on 15 pending and granted patents in fields of medical devices\, immunology\, dermatology\, cardiology\, and medical innovation. Her research focuses on innovative biomedical translational discoveries aimed at identifying unmet medical needs and working with multidisciplinary teams to develop novel treatments. She used this same approach to pioneer injectable cooling devices for aesthetic and medical application since 2012. Several of her inventions have been licensed and led to venture-backed startup companies. She is the co-founder of two startup biotech companies which have resulted from her research discoveries. She serves on several scientific advisory boards for startup companies. \nDr. Garibyan is the co-founder and the Director of the “Magic Wand Initiative” and the Virtual Magic Wand programs\, which teach the process of innovation. These internationally recognized programs empower\, engage\, and teach professionals on how to identify unmet needs and collaborate to identify and implement solutions to problems. \nAs a humanitarian\, Dr. Garibyan has pioneered and established sustainable\, medical laser clinics in Armenia for effective treatments of scars and vascular anomalies. Her team has taken several lasers to Armenia and has trained Armenian physicians on the use of laser technology to treat life altering skin diseases. Dr. Garibyan recently founded and serves as the President of a nonprofit organization called “Face of Angel” to continue the mission of this humanitarian work. \nDr. Garibyan received her B.S. summa cum laude from University of California Los Angeles\, her M.D. from Harvard Medical School and her\nPh.D. from Harvard University in Experimental Pathology/Immunology. \n  \nREGISTER HERE FOR ZOOM \n  URL:https://leadersinlight.com/event/lilit-garibyan-md-phd-faad/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/01/Lilit-Garibyan.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20221027T120000 DTEND;TZID=America/Los_Angeles:20221027T130000 DTSTAMP:20260513T121947 CREATED:20230109T214453Z LAST-MODIFIED:20230109T214453Z UID:31140-1666872000-1666875600@leadersinlight.com SUMMARY:Gultekin Gulsen\, Ph.D. DESCRIPTION:True multi-modality optical molecular imaging – where both modalities interact and work in harmony. \nAbstract \nThe main goal of the molecular imaging community has been achieving higher resolution and better quantitative accuracy.\nFor nearly two decades\, I have been spending effort for the same purpose\, mainly integrating optical imaging with anatomic\nimaging modalities such as MRI and X-ray CT. For example\, my team has developed a gantry-based combined X-ray CT and\nFluorescence Tomography system for small animal imaging. This system is unique in that both X-ray CT and optical imaging\nsystems are on the same gantry rotating around the animal and capable of revealing cross-sectional background optical\nabsorption map and anatomic images that can be used to obtain quantitatively correct fluorophore concentration maps.\nAnother hybrid system that is being developed in my lab is a combined MRI-Diffuse Optical Tomography scanner for small\nanimal imaging in both absorbance & fluorescence modes. \nIn all of these applications\, optical and anatomic imaging modalities worked in harmony but independent from each other.\nRecently\, we have focused on development of novel multimodality techniques\, in which optical and anatomic imaging\nmodalities work in harmony and interact with each other to provide images that cannot be obtained solely with one or the\nother. This talk will highlight two of these true-multimodality imaging techniques developed in our lab: Photo-magnetic\nImaging (PMI) and Temperature Modulated Fluorescence Tomography (TM-FT)\, where optical tomography is achieved at MRI\nand Focused Ultrasound resolution\, respectively while preserving its superior sensitivity. \n  \nBiography \nDr. Gulsen is an Associate Professor in the Departments of Radiological Sciences\, Biomedical Engineering\, Physics & Astronomy\, and Electrical Engineering & Computer Science at the University of California\, Irvine. He has been serving as the Director of In vivo Functional Onco-Imaging Shared Resource of the UCI Cancer Center for more than15 years. His research involves development of both cutting-edge instrumentation and novel mathematical algorithms for multi-modality imaging techniques. Although most of those techniques have been related to optical molecular tomography\, his team was also involved in development of the the world’s first MR compatible SPECT small animal imaging and Positron Emission\nMammography systems. \n  \n  URL:https://leadersinlight.com/event/gultekin-gulsen-phd/ LOCATION:Zoom Event\, CA\, United States CATEGORIES:LAMP Seminar ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2023/01/Gultekin-UCI-best-pic.jpg END:VEVENT END:VCALENDAR