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X-WR-CALDESC:Events for Beckman Laser Institute
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DTSTART;TZID=UTC:20220224T120000
DTEND;TZID=UTC:20220224T130000
DTSTAMP:20260513T200639
CREATED:20220214T211746Z
LAST-MODIFIED:20220214T214408Z
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SUMMARY:Dr. Dmitri Lapotko\, Ph.D.\, D.Sc.
DESCRIPTION:Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles \nAbstract\nTo improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer\, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale\, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event\, plasmonic nanobubble\, results from a novel physical-biological mechanism. Its mechanical impact was tuned to support cell level diagnostics\, drug release and intracellular injection of genetic or therapeutic payloads\, to enhance chemoradiation therapies in highly resistant and aggressive tumors\, to intraoperatively detect and destroy unresectable residual microtumors\, and to non-invasively detect bad actors\, all in personalized procedures with safe doses of nanoparticles and laser energies. Plasmonic nanobubble platform can be integrated with current or novel medical approaches to improve clinical outcomes where standards of care fail. \nBiography\nDmitri Lapotko obtained his MS in thermal physics and Ph.D. in laser applications from Belarus State University and Doctor of Science in bioengineering from Lyikov Heat and Mass Transfer Institute. His research in biophotonics and nanotechnology in basic\, applied and clinical science resulted in the invention of photothermal microscope for functional analysis of live cells\, laser-generated vapor nanobubbles (plasmonic nanobubbles) as a novel platform for diagnostic\, therapeutic and surgical technologies for cancer\, malaria and cardiovascular disease applications. \n  \nREGISTER HERE \n 
URL:https://leadersinlight.com/event/dr-dmitri-lapotko-ph-d-d-sc/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/02/Dmitri-Lapotko.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20211007T120000
DTEND;TZID=UTC:20211007T130000
DTSTAMP:20260513T200639
CREATED:20220608T191355Z
LAST-MODIFIED:20220608T191355Z
UID:30597-1633608000-1633611600@leadersinlight.com
SUMMARY:Quinton Smith\, Ph. D.
DESCRIPTION:Harnessing Physiological Forces to Drive Stem Cell Fate & Function \nAbstract\nI will be elaborating about how physical cues are crucial to embryonic development\, morphogenic events\, and tissue organization\, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such\, the role of substrate stiffness\, fluid shear stress\, and confinement was interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates\, as opposed to traditionally used rigid plastic surfaces\, promotes efficient endothelial specification in the absence of growth factor supplementation. Leveraging micropatterned domains\, which restrict extracellular matrix accessibility\, also enhances endothelial specification and early lineage organization. Finally\, using a microfluidic platform\, we find that primary cilia\, a microtubule-based mechanosensor\, is crucial to stem cell derived endothelial shear response. Collectively\, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools. \nBiography\nQuinton Smith is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Sue & Bill Gross Stem Cell Research Center\, Irvine. Quinton Smith received his bachelor’s degree from the University of New Mexico in\nchemical engineering and his Ph.D. in 2017 from Johns Hopkins University in chemical and biomolecular engineering. His predoctoral research was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. Additionally\, he was named a Siebel Scholar in 2017. After completing his doctorate\, he trained as a Howard Hughes Medical Institute Hanna Gray Postdoctoral Fellow at the Massachusetts Institute of Technology. Dr. Smith joined the University of California Irvine in Spring 2021 and is currently an Assistant Professor in the Department of Chemical and Biomolecular Engineering and a member of the Sue Bill Gross Stem Cell Research Center. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/quinton-smith-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Quinton_Smith.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210923T120000
DTEND;TZID=UTC:20210923T130000
DTSTAMP:20260513T200639
CREATED:20220608T193312Z
LAST-MODIFIED:20220608T193312Z
UID:30609-1632398400-1632402000@leadersinlight.com
SUMMARY:Andy Shih\, Ph. D.
DESCRIPTION:Optical Dissection of Brain Capillary Function \nAbstract\nMy laboratory uses in vivo multiphoton imaging and rodent models to shed light (quite literally) on regulation of cerebral blood flow. In particular\, we have focused recent attention on the vast capillary networks that distribute blood throughout the brain. We use light to both visualize capillary structure and flow\, as well as noninvasively manipulate neurovascular cells that control capillary flow. We specialize in the application and development of in vivo multi-photon imaging approaches to study brain microvascular structure and function in rodents. Our recent findings include the construction of capillary networks during early postnatal development\, regulation of blood flow in adulthood by capillary pericytes\, and capillary changes in gray and white matter that may contribute to metabolic insufficiencies during aging and dementia. I firmly believe that our efforts will provide a unique and physiologically relevant view of microvascular function\, dysfunction\, and repair\, and will yield strategies for protecting vascular function in diseases that degrade the brain’s microvasculature. \nBiography\nAndy Shih is an Assistant Professor in the department of Developmental Biology & Regenerative Medicine at Seattle Children’s Research Institute. Additionally\, he is an assistant professor in the Department of Bioengineering and Department of Pediatrics at the University of Washington. His research focuses on optogenetic approaches to manipulate pericyte contractility in the intact brain\, and studies to delineate pathological features of mural cells in advanced age and small vessel disease. Shih earned a B.S. in Cell Biology and genetics from the University of British Columbia (2010) and Ph.D. in Neuroscience. He has completed his postdoc and been a project scientist from University of California\, San Diego (2012). Shih has been invited to several symposiums and been part of the SfN Nanosymposium chair (Stroke and Injury\, 2016) where he elaborates about his extensive findings & projects. A complete list of his published works in Google Scholar & NIH Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=andy+y+shih \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/andy-shih-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/shih.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210729T120000
DTEND;TZID=UTC:20210729T130000
DTSTAMP:20260513T200639
CREATED:20220608T192629Z
LAST-MODIFIED:20220608T192629Z
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SUMMARY:Herdeline (Digs) Ardoña\, Ph. D.
DESCRIPTION:Hierarchical Strategies Towards Biointerfacing With Soft Optoelectronic Materials  \nAbstract\nThe applications of functional nanomaterials towards biological interfacing continue to emerge in various fields\, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems\, these biomaterials are rarely synthesized with optical and electronic functionalities that could be beneficial for controlling the behavior of excitable cells (e.g.\, neurons and cardiac cells) or for biosensing applications. In this seminar\, I will first describe the development of one-dimensional peptidic nanostructures appended with organic electronic units\, which can facilitate photoinduced energy transfer under aqueous environments. These semiconducting peptide monomers that self-assemble as aligned hydrogels are successfully built according to design principles that allowed for directed photonic energy transport\, sequential electron transport in a multicomponent system\, and transmission or equilibration of voltage or current when incorporated in a transistor device. These soft scaffolding materials\, with tunable molecular to macroscale properties\, offer a unique tissue engineering platform that can locally and synergistically deliver electronic\, topographical\, and biochemical cues to cells. In the second part of the talk\, I will describe how to engineer in vitro models of cells and tissues which enables the understanding of nano-bio or abiotic-biotic interactions at multiple spatial scales. I will specifically describe physiologically relevant models that faithfully recapitulate the native form and function of cells or tissues involved in the systemic biodistribution of common nanomaterials—across biological barriers to target organs. These testing platforms were used to elucidate the dynamic structural and functional outcomes resulting from the exposure of vascular endothelium and myocardium to engineered nanomaterials. Finally\, this presentation will discuss the future applications of biopolymer assemblies with photonic and electronic functionalities as tools for controlling cellular processes and probing biophysical phenomena\, such as mechanotransduction and drug/toxicant permeation across tissues. \nBiography\nHerdeline Ann (Digs) M. Ardoña is originally from Valenzuela City\, Philippines. She received her B.S. in Chemistry (summa cum laude) from the University of the Philippines Diliman in 2011. In 2017\, she completed her Ph.D. in Chemistry at Johns Hopkins\, with funding support from Schlumberger Foundation and Howard Hughes Medical Institute. Her dissertation was focused on understanding the molecular design\, photophysical properties\, and supramolecular principles towards developing pi-conjugated peptide assemblies as bioelectronic nanomaterials. She then worked as a postdoctoral researcher in the Disease Biophysics Group at the Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences at Harvard University. As the 2018-2020 ACS Irving S. Sigal Postdoctoral Fellow\, she investigated the structural and functional impacts of multiple engineered nanomaterials through microphysiological platforms and biohybrid models. Digs started as an Assistant Professor at the UCI Department of Chemical and Biomolecular Engineering in Fall 2020. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/herdeline-digs-ardona-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Ardona_Photo.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20210617T120000
DTEND;TZID=UTC:20210617T130000
DTSTAMP:20260513T200639
CREATED:20220608T192056Z
LAST-MODIFIED:20220608T192056Z
UID:30601-1623931200-1623934800@leadersinlight.com
SUMMARY:Philip Scumpia\, Ph. D.
DESCRIPTION:Translating an understanding of the cutaneous microenvironment into diagnostics and treatments for wounds\, cancers\, and inflammatory dermatoses \nAbstract\nImmune cells are the first responders to injury\, pathogens\, or malignancy. The various components of the tissue microenvironment dictate what immune cells do when they reach different tissues. The Scumpia lab studies how different components of the unique cutaneous microenvironment affect outcome following wounding\, bacterial infection\, or cancer. The overall goal is to develop an understanding of the cutaneous microenvironment regulates skin disease and to translate this knowledge into new diagnostics and therapies. \nBiography\nDr. Scumpia received a BS in Microbiology and Cell Sciences from the University of Florida. He received his M.D. and PhD. from the University of Florida where he studied the immunobiology of sepsis. He completed his residency and fellowship training in Dermatology and Dermatopathology at UCLA. He is currently an Assistant Professor in the Department of Medicine at UCLA where he studies how various components of the cutaneous microenvironment including nerves\, lipids\, and extracellular matrix\, regulate skin diseases. The goal is to translate this understanding into novel diagnostics and potential therapeutics. He is currently a member of the American Academy of Dermatology and the Society of Investigative Dermatology. \n  \nSponsored by the Michael and Roberta Berns Laser Microbeam Program
URL:https://leadersinlight.com/event/philip-scumpia-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2022 Virtual Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://leadersinlight.com/wp-content/uploads/2022/06/Scumpia.jpg
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