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DTSTART;TZID=America/Los_Angeles:20231121T120000
DTEND;TZID=America/Los_Angeles:20231121T130000
DTSTAMP:20260513T150710
CREATED:20250325T212039Z
LAST-MODIFIED:20250325T212039Z
UID:32952-1700568000-1700571600@leadersinlight.com
SUMMARY:Xunbin Wei\, Ph.D.
DESCRIPTION:Light Treatment of Alzheimer’s Disease\nAbstract  \nPhotobiomodulation\, by utilizing low-power light in the visible or near-infrared spectrum to trigger biological responses in cells and tissues\, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD)\, while its specific mechanisms have remained elusive. Here\, we provide evidence that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden\, the hallmark of AD. The glial cells\, including microglia and astrocytes\, play important roles in Aβ clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with Aβ are sufficient to reduce Aβ load in AD mice. \nMoreover\, we demonstrate that 1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further improve Aβ clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic\napproach for AD. \nBiography \nDr. Wei received his bachelor in physics from University of Science and Technology of China\, Hefei. He received his PhD from Department of Physiology and Biophysics\, University of California\, Irvine. Dr. Wei completed his post-doc training at Children’s Hospital\, Harvard Medical School. From 2006-2010\, he was a professor in Fudan University\, China. From 2006-2010\, he was a professor and chair in Department of Biomedical Instrumentation\, School of Biomedical Engineering\, Shanghai Jiao Tong University\, China. \nCurrently\, he is a professor at Department of Biomedical Engineering\, Peking University. Dr. Wei is an SPIE Fellow\, and recipient of Chinese Outstanding Young Scholar Award. He has published more than 120 peer-reviewed papers\, including in Nature and PNAS. His research interests include cancer detection by optical means\, optical manipulation of cells\, and light treatment of Alzheimer disease. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://leadersinlight.com/event/xunbin-wei/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230808T150000
DTEND;TZID=UTC:20230808T160000
DTSTAMP:20260513T150710
CREATED:20250325T205417Z
LAST-MODIFIED:20250325T205542Z
UID:32940-1691506800-1691510400@leadersinlight.com
SUMMARY:Woonggyu Jung\, Ph.D.
DESCRIPTION:Staining-free optical imaging techniques toward digital histopathology \nAbstract \nThe histological optical imaging is a gold standard method to observe the biological tissues\, which follows routine process such as dissection\, embedding\, sectioning\, staining\, visualization and interpretation of specimens. This technique has a long history of development\, and is used ubiquitously in pathology\, despite being highly time and labour-intensive. Advanced optical imaging techniques developed over the last decade have enabled to provide high sensitivity\, high resolution and non-invasive biological information. In particular\, new optical imaging contrast rather than chemical staining has been presented to be utilized in histopathology while showing the strong potential. However\, acquiring high throughput\, large volume tissue anatomy remains a difficult challenge due to the effect of light scattering\, which limits the penetration imaging depth and lateral resolution. Recently\, various optical imaging methods have been introduced to\ncreate volumetric anatomy data of ex vivo tissues using physical tissue sectioning or optical clearing. \nHere\, we introduce novel staining-free and multi-scale imaging modality based on scattering and phase contrast. Optical staining in histopathology could be key technique to build fast feedback of anatomy of tissues or organs due to its simplicity\, efficiency\, robustness\, and high-throughput capabilities. This presentation covers the latest work of large-scale and fast tissue imaging using optical coherence microscopy\, quantitative phase imaging and projection tomography. Specifically\, the talk will highlight comparison study over the conventional method in histopathology and its adaptation with artificial intelligence such as the virtual staining and resolution enhancement. \nBiography \nWoonggyu Jung received his Ph. D. in 2008 from the Department of Biomedical Engineering at the University of California\, Irvine. From 2001 to 2008\, he worked at the Beckman Laser Institute and Medical Clinic at UC Irvine. He also worked at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign since January 2009. He has joined the faculty of UNIST in 2012\, and currently works as an associate professor of Department of Biomedical Engineering. He is also co-founder and CTO of start-up company\, Conecson which is focused on the futuristic business regarding to mobile-based medical devices. Dr. Jung has a strong research background in optical imaging technologies including optical coherence tomography (OCT)\, quantitative phase microscope (QPM)\, and miniaturized optical imaging probes. His research interest is to develop new optical technologies that address challenges in clinical medicine\, basic biological research and neuroscience. In previous work\, he developed a successful optical platform for in vivo translational research\, and has published more than 60 peer-reviewed journal papers in the field of biophotoics. \nFor more information or to schedule a meeting with the speaker\, please contact Xandra Dvornikova. \nSponsored by the Berns Family Laser and Microbeam Program \nHosted by: Dr. Zhongping Chen
URL:https://leadersinlight.com/event/woonggyu-jung-2/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230615T120000
DTEND;TZID=America/Los_Angeles:20230615T130000
DTSTAMP:20260513T150710
CREATED:20250325T204318Z
LAST-MODIFIED:20250325T204318Z
UID:32933-1686830400-1686834000@leadersinlight.com
SUMMARY:Hyunmo Yang\, Ph.D.
DESCRIPTION:Deep Learning Applications in Biomedical Imaging\nAbstract  \nRecently developed deep learning techniques revolutionized image analysis methods in the last decade. Classification\, segmentation\, quantitative prediction\, and generating new data can be performed by the training of deep learning models. These tasks can directly be applied to biomedical imaging and successful applications will provide strong advantages to researchers and physicians in terms of efficiency for their studies and improvement in diagnosis. \nIn this talk\, I will discuss my recent studies that using deep learning techniques to the following topics: glaucoma screening from fundus photographs based on regional retinal nerve fiber layer (RNFL) thickness estimation using deep learning\, label-free digital histopathology with QPI imaging based on virtual staining and image classification techniques\, and high-throughput phenotype screening platform using office scanner. For these studies\, we have employed the convolution neural network (CNN) network architectures and trained them to perform image-to-number regression\, image classification\, image segmentation\, and image-to-image generation. The details of each approach will be also discussed. \nBiography \nDr. Hyunmo Yang earned his Ph.D. in physics from Ulsan National Institute of Science of Technology (UNIST) in Korea. After his degree in 2019\, he joined as a postdoc researcher to the translational biophotonics laboratory in department of biomedical engineering at UNIST. He is currently working on developing machine learning and deep learning applications for biomedical imaging. His research interests are digital medicine\, digital screening and digital histopathology using A.I. technology. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://leadersinlight.com/event/hyunmo-yang/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230427T120000
DTEND;TZID=America/Los_Angeles:20230427T130000
DTSTAMP:20260513T150710
CREATED:20250325T203342Z
LAST-MODIFIED:20250325T204503Z
UID:32928-1682596800-1682600400@leadersinlight.com
SUMMARY:Roukuya Mamuti\, Ph.D.
DESCRIPTION:Tunable infrared structured laser generation and opto-thermal trapping of micro/nano particles\nAbstract  \nThis talk covers the experimental research and theoretical investigation of mid-infrared tunable optical vortex sources with versatile orbital angular momentum (OAM) and opto-thermophoretic trapping of micro and nano particles with mid-infrared fiber lasers. As a typical structured light\, optical vortex with a helical wavefront exhibits interesting physical properties\, including an annular spatial intensity profile and an OAM of owing to an on-axial phase singularity. Such properties of the vortex beam have been widely utilized in diverse applications. In the talk\, Dr. Mamuti presents generation of optical vortices with versatile OAM states from a nanosecond optical parametric oscillator (OPO) by appropriately shortening or extending the cavity. The system with a compact cavity configuration enables the production of a millijoule-level signal (idler) output with l =1~3 (0~-2) simply by tuning the wavelength of signal output. The system was further developed to create coherently coupled OAM states\, i.e.\, flower-shaped signal and wheel-shaped idler outputs\, arising from the coherent superposition of opposite-signed OAM states. \nFurthermore\, Dr. Mamuti proposed a method for opto-thermophoretic trapping with a 2 μm Tm-doped fiber laser. The infrared continuous-wave laser beam is directly and strongly absorbed by water solution\, and some local temperature gradient is generated around the focus. The particles are migrated along the temperature gradient and form a hexagonal close-packed structure at a bottom-glass solution interface. She has investigated the dependence of the phenomenon on the material\, particle size\, and laser power. Since the water molecules have a significant absorption in the 3-μm wavelength band\, a midinfrared Er:ZBLAN tunable fiber laser is applied for opto-thermophoretic trapping of particles diffusing in water. Through the laser wavelength dependence and single particle tracking analysis\, they found that particles are rapidly collected at the laser focus which is much faster than near infrared lasers. The system with 2 μm and 3 μm direct optothermal trapping could be extended in various fields\, such as bio sensing\, detection\, and sorting. \nBiography \nDr. Roukuya Mamuti received her Master’s and Ph.D. degrees in Optical Engineering from laser laboratory\, Chiba University\, Japan. Her graduate research mainly focused on the generation of tunable infrared structured lasers. After graduation\, she worked as a postdoctoral researcher at Laser Lab (the same lab where she earned her degree). Dr. Mamuti received 2 million Japanese yen of research grant from Kambayashi foundation (private funding). Later\, she worked in the Laser Science Laboratory at Toyota Technological Institute\, to develop optical trapping of micro/nano particles. Now\, she is seeking a research position to pursue her profession in laser-related research fields. \n  \nREGISTER HERE FOR ZOOM \n  \nClick here to register for in-person attendance (lunch will be served) \n 
URL:https://leadersinlight.com/event/roukuya-mamuti/
LOCATION:BLI Library
CATEGORIES:2023 Virtual Seminar Series,LAMP Seminar
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2025/03/Screenshot-2025-03-25-133315.png
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230420T090000
DTEND;TZID=America/Los_Angeles:20230420T100000
DTSTAMP:20260513T150710
CREATED:20230413T235332Z
LAST-MODIFIED:20250325T201003Z
UID:31266-1681981200-1681984800@leadersinlight.com
SUMMARY:Martin Lavery\, Ph.D.
DESCRIPTION:Environmental and Fiber Sensing with Structured Light \nAbstract  \nStructured light is being widely used to revolutionize the technologies used in optical trapping\, microscopy\, astronomical metrology\, optical communication\, quantum information systems\, and many others. One defines an optical wavefront that has been spatially shaped in its phase\, polarisation or intensity as structured light. Prof. Lavery will present an introduction to the research field and an overview of their work in the Structured Photonics Research Group\, at the University of Glasgow\, in the creation\, detection\, and application of shaped optical beams for a range of sensing applications. He will discuss the development of technologies to generate and measure structured light\, including reconfigurable platforms based on silicon Photonic Integrated Circuits (PICs). \n Further\, he will present their recent advances in utilising structured light for sensing in complex optical environments such as underwater scattering\, atmospheric turbulence\, and multimode optical fibers. They have developed approaches that use spatial mode sensitive receivers to extract features buried in aberrated optical fields that can increase the accuracy of the measurement of particulates in submersed channels\, measure wind speed and temperature from the air\, and sense changes in the shape of optical fibers. These sensors could be used for environmental pollution sensing in water\, failure monitoring in mechanical systems\, and sub-km weather monitoring critical for developing accurate climate models. \nBiography \nProfessor Martin Lavery is a Full Professor in Optics and is the leader of the Structured Photonics Research Group at the James Watt School of Engineering at the University of Glasgow (UofG). Prof. Lavery has a portfolio\nof over $6 million in independent research funding as Principal Investigator (PI) and is leading the H2020 Future and Emerging Technologies (FET-Open) consortium project named SuperPixels\, each of which have an array of international partners from both industry and academia. He has held the prestigious Royal Academy of\nEngineering (RAEng) Research Fellowship from 2014-2019. Prof. Lavery’s H-index is 41 with over 60 publications in peer-reviewed journals and over 80 conference\nmanuscripts that have collectively attracted over 11\,000 citations (Google Scholar\, Dec 2022). He has been awarded the 2013 Scopus Young Scientist of the Year for Physical Sciences\, the 2018 Mobile World Scholar Gold Medal\, and the 2019 Royal Society of Edinburgh Sir Thomas Makdougall Brisbane Medal for accomplishments in\noptical communication and sensing. \nREGISTER HERE FOR ZOOM \n 
URL:https://leadersinlight.com/event/martin-lavery-ph-d/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2023 Virtual Seminar Series
ATTACH;FMTTYPE=image/png:https://leadersinlight.com/wp-content/uploads/2023/04/image.1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230330T090000
DTEND;TZID=America/Los_Angeles:20230330T100000
DTSTAMP:20260513T150710
CREATED:20230328T165357Z
LAST-MODIFIED:20230328T165742Z
UID:31224-1680166800-1680170400@leadersinlight.com
SUMMARY:Daniel Razansky\, Ph.D.
DESCRIPTION:Cardio-oncology; Advanced optoacoustic imaging methods for biomedical research and clinical diagnostics \nAbstract  \nOptoacoustic imaging has achieved remarkable progress over the last decade\, benefiting from coordinated developments in optical and ultrasound technology\, probe chemistry\, and imaging theory. The technique is increasingly attracting attention of the biomedical research community due to its excellent spatial and temporal resolution\, centimeter scale penetration into living tissues\, versatile endogenous and exogenous optical absorption contrast. State-of-the-art implementations of multispectral optoacoustic tomography are based on multi-wavelength excitation of tissues to visualize specific molecules within opaque tissues. As a result\, optoacoustics can noninvasively deliver structural\, functional\, metabolic\, and molecular information from living tissues. \nThe talk covers advances in optoacoustic microscopy and tomography instrumentation\, reconstruction algorithms for ultrafast imaging\, as well as synergistic combinations with fluorescence\, magnetic resonance and ultrasound methods. Efforts are underway to explore potential of the technique in studying multi-scale dynamics of the brain and heart\, monitoring of therapies\, targeted molecular imaging applications and clinical diagnostics of patients in a number of indications\, such as breast and skin lesions\, inflammatory diseases and cardiovascular diagnostics. \nBiography \nProfessor Daniel Razansky holds the Chair of Biomedical Imaging with double appointments at the Faculty of Medicine\, University of Zurich and Department of Information Technologies and Electrical Engineering\, ETH Zurich in Switzerland\, where he also serves as Director of the joint Preclinical Imaging Center. \nHe earned degrees in Biomedical and Electrical Engineering from the Technion – Israel Institute of Technology and conducted postdoctoral research at the Harvard Medical School. Previously\, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich in Germany. \nThe Razansky Lab pioneered a number of bio-imaging technologies that were successfully commercialized and put into use in research labs and clinical facilities across the globe\, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). His research has been recognized by the German Innovation Prize and multiple awards from the ERC\, NIH\, SNF\, DFG and HFSP. He is also Fellow of the IEEE\, SPIE and Optica Societies. \nREGISTER HERE FOR ZOOM \n 
URL:https://leadersinlight.com/event/daniel-razansky-phd/
LOCATION:Zoom Event\, CA\, United States
CATEGORIES:2023 Virtual Seminar Series
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